Titus Boggon, PhD
Professor of PharmacologyCards
About
Research
Publications
2026
Clinically observed RASA1 missense mutants exhibit diverse RasGAP protein behaviors in vitro
Paul M, Delelegne R, Chau J, Boggon T. Clinically observed RASA1 missense mutants exhibit diverse RasGAP protein behaviors in vitro. Journal Of Biological Chemistry 2026, 302: 113201. PMID: 42208894, PMCID: PMC13311836, DOI: 10.1016/j.jbc.2026.113201.Peer-Reviewed Original ResearchDual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression
Huet-Calderwood C, Fisher O, Das S, Su V, Boggon T, Calderwood D. Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression. Nature Communications 2026, 17: 2719. PMID: 41688454, PMCID: PMC13013565, DOI: 10.1038/s41467-026-69595-7.Peer-Reviewed Original ResearchThis study investigates how two CCM2 proteins must bind a single KRIT1 protein to regulate KLF4 expression, a process critical for vascular health.
2025
Structural basis for MEKK2 dimerization and substrate recognition
Vish K, Huet-Calderwood C, Ha B, Calderwood D, Boggon T. Structural basis for MEKK2 dimerization and substrate recognition. Nature Communications 2025, 17: 193. PMID: 41318559, PMCID: PMC12780230, DOI: 10.1038/s41467-025-66884-5.Peer-Reviewed Original ResearchOptimized conditions for GTP loading of Ras
Vish K, Paul M, Rollins A, Boggon T. Optimized conditions for GTP loading of Ras. Journal Of Biological Chemistry 2025, 301: 110923. PMID: 41207625, PMCID: PMC12719659, DOI: 10.1016/j.jbc.2025.110923.Peer-Reviewed Original ResearchNickel binding to c-Src SH3 domain facilitates crystallization
Calicdan X, Fisher O, Ha B, Boggon T, Stiegler A. Nickel binding to c-Src SH3 domain facilitates crystallization. Protein And Peptide Letters 2025, 32: 679-692. PMID: 41088944, PMCID: PMC12582252, DOI: 10.2174/0109298665417324250929120040.Peer-Reviewed Original ResearchMichaelis-Menten kinetics of RasGAP proteins by a rapid fluorescence-based assay
Paul M, Vish K, Boggon T. Michaelis-Menten kinetics of RasGAP proteins by a rapid fluorescence-based assay. Methods 2025, 244: 108-117. PMID: 40930400, PMCID: PMC12453608, DOI: 10.1016/j.ymeth.2025.09.003.Peer-Reviewed Original ResearchSHP2 genetic variants in NSML-associated RASopathies disrupt the PZR–IRX transcription factor signaling axis
Perla S, Stiegler A, Yi J, Enyenihi L, Zhang L, Riaz M, An E, Qyang Y, Boggon T, Bennett A. SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR–IRX transcription factor signaling axis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2503631122. PMID: 40854126, PMCID: PMC12415285, DOI: 10.1073/pnas.2503631122.Peer-Reviewed Original ResearchComplement factor I deficiency–associated neuroinflammatory disease among Old Order Amish
Reid W, Baas L, Stiegler A, Boggon T, Kreiger P, Sullivan K, Behrens E, Kandula V, van den Heuvel L, Brigatti K, Carson V, Romberg N. Complement factor I deficiency–associated neuroinflammatory disease among Old Order Amish. The Journal Of Allergy And Clinical Immunology 2025, 156: 835-841. PMID: 40602690, PMCID: PMC13058855, DOI: 10.1016/j.jaci.2025.06.021.Peer-Reviewed Original ResearchNovel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia
Daddali R, Kettunen K, Turunen T, Knox A, Laine P, Chowdhury I, Vänttinen M, Mamia N, Stiegler A, Boggon T, Kere J, Romberg N, Seppänen M, Varjosalo M, Martelius T, Grönholm J. Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia. Clinical Immunology 2025, 277: 110503. PMID: 40294836, DOI: 10.1016/j.clim.2025.110503.Peer-Reviewed Original ResearchCancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions
Robles J, Stiegler A, Boggon T, Turk B. Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions. Journal Of Biological Chemistry 2025, 301: 108348. PMID: 40015635, PMCID: PMC11982978, DOI: 10.1016/j.jbc.2025.108348.Peer-Reviewed Original Research
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Academic Office Number
Lab Number
Mailing Address
Pharmacology
PO Box 208066, 333 Cedar Street
New Haven, CT 06520-8066
United States
Locations
Sterling Hall of Medicine, B-Wing
Academic Office
333 Cedar Street, Ste SHM B316A
New Haven, CT 06510
Sterling Hall of Medicine, B-Wing
Lab
333 Cedar Street, Ste Suite 302
New Haven, CT 06510
Events
Oct 202622Thursday
Yale Only Yong Xiong, PhD
Mar 202711Thursday
Yale Only Oriana Fisher