2020
Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron
Gao PP, Graham JW, Zhou WL, Jang J, Angulo S, Dura-Bernal S, Hines M, Lytton WW, Antic SD. Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron. Journal Of Neurophysiology 2020, 125: 23-42. PMID: 33085562, PMCID: PMC8087381, DOI: 10.1152/jn.00734.2019.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsDendritic plateau potentialsPyramidal neuronsPlateau potentialsCell bodiesBasal dendritesAfferent inputDendritic potentialsAction potentialsThin basal dendritesSomatic input resistanceThin dendritic branchesLocal dendritic potentialNeuronal statesGlutamatergic inputsFunctional neuronal ensemblesTau changesCortical neuronsVoltage-sensitive dyeDendritic spikesMembrane time constantStimulation intensityOblique branchNeuronsInput resistance
2017
The stochastic nature of action potential backpropagation in apical tuft dendrites
Short SM, Oikonomou KD, Zhou WL, Acker CD, Popovic MA, Zecevic D, Antic SD. The stochastic nature of action potential backpropagation in apical tuft dendrites. Journal Of Neurophysiology 2017, 118: 1394-1414. PMID: 28566465, PMCID: PMC5558024, DOI: 10.1152/jn.00800.2016.Peer-Reviewed Original ResearchConceptsDendritic CaPyramidal neuronsApical tuftCortical pyramidal neuronsAction potential backpropagationRat brain slicesSpontaneous synaptic inputsDifferent cortical layersVoltage-gated CaAP backpropagationAP burstsGlutamate iontophoresisSynaptic contactsSomatic APsApical trunkAP frequencyBrain slicesDendritic physiologySynaptic inputsCortical layersChannel inactivationLocal NaNeuronsSpike-timing dependent plasticityTrials
2014
Branch specific and spike-order specific action potential invasion in basal, oblique, and apical dendrites of cortical pyramidal neurons
Zhou W, Short S, Rich M, Oikonomou K, Singh M, Sterjanaj E, Antic S. Branch specific and spike-order specific action potential invasion in basal, oblique, and apical dendrites of cortical pyramidal neurons. Neurophotonics 2014, 2: 021006-021006. PMID: 26157997, PMCID: PMC4478750, DOI: 10.1117/1.nph.2.2.021006.Peer-Reviewed Original ResearchPyramidal neuronsAction potentialsDendritic branchesTrains of APsCortical pyramidal neuronsL5 pyramidal neuronsSame cortical layerNeocortical pyramidal neuronsAction potential invasionThin dendritic branchesAP backpropagationApical dendritesAP trainsApical trunkSame neuronsDendritic diameterDistal synapsesCalcium transientsVariable efficacyCalcium imagingCortical layersDendritic treeDendritic voltageOblique branchMultisite optical recordings
2012
Dopaminergic Regulation of Dendritic Calcium: Fast Multisite Calcium Imaging
Zhou W, Oikonomou K, Short S, Antic S. Dopaminergic Regulation of Dendritic Calcium: Fast Multisite Calcium Imaging. Methods In Molecular Biology 2012, 964: 123-138. PMID: 23296782, DOI: 10.1007/978-1-62703-251-3_9.Peer-Reviewed Original ResearchConceptsDendritic calcium transientsCalcium transientsDendritic treeNormal cortical functionIndividual cortical neuronsElaborate dendritic treesNeocortical pyramidal neuronsSomatic action potentialsDendritic calciumGlutamatergic inputsPyramidal neuronsDopaminergic drugsDopaminergic regulationCortical neuronsDopaminergic modulationCortical functionExogenous dopamineSynaptic integrationAction potentialsCalcium imagingDopamine toneDendritic compartmentsDopaminergic signalsDendritic branchesCalcium fluctuationsRapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons
Zhou W, Antic S. Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons. The Journal Of Physiology 2012, 590: 3891-3911. PMID: 22641784, PMCID: PMC3476639, DOI: 10.1113/jphysiol.2011.227157.Peer-Reviewed Original ResearchConceptsDendritic calcium transientsAction potentialsDopamine effectsSame dendriteCalcium transientsPrefrontal cortex pyramidal neuronsT-type calcium channel blockersDendritic calcium influxCortex pyramidal neuronsCalcium channel blockersMidbrain dopaminergic neuronsCalcium-sensitive dyeAP backpropagationDopaminergic stimulationGABAergic modulationPyramidal neuronsDopaminergic neuronsPulses of GABAD1 antagonistDopamine applicationDopaminergic suppressionDopaminergic inputSomatic excitabilityD1 agonistChannel blockers
2010
Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons
Moore A, Zhou W, Potapenko E, Kim E, Antic S. Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons. Brain Research 2010, 1370: 1-15. PMID: 21059342, PMCID: PMC3019254, DOI: 10.1016/j.brainres.2010.10.111.Peer-Reviewed Original ResearchConceptsPyramidal neuronsMidbrain dopaminergic neuronsPrefrontal cortexDopaminergic neuronsLayer 5 pyramidal neuronsRat medial prefrontal cortexAction potential firing ratePFC pyramidal neuronsPrefrontal pyramidal neuronsD1-like receptorsDirect synaptic contactsAction potential firingMedial prefrontal cortexDose-dependent responseDopaminergic stimulationIontophoretic pulsesCortical excitabilitySynaptic contactsDopaminergic agonistsSevere depressionPyramidal cellsTransient physiological changesBrain slicesAction potentialsCell bodiesThe decade of the dendritic NMDA spike
Antic S, Zhou W, Moore A, Short S, Ikonomu K. The decade of the dendritic NMDA spike. Journal Of Neuroscience Research 2010, 88: 2991-3001. PMID: 20544831, PMCID: PMC5643072, DOI: 10.1002/jnr.22444.Peer-Reviewed Original ResearchConceptsDendritic NMDA spikesNMDA spikesPyramidal cellsPlateau potentialsActive synaptic inputsApical tuft dendritesGlutamatergic synaptic contactsThick apical dendritesLong-term synaptic modificationsNeuronal cell bodiesCortical pyramidal cellsSlow-wave sleepCortical UP statesDendritic regenerative potentialsCortical information processingBasal dendritesPyramidal neuronsApical dendritesSynaptic contactsApical trunkTuft dendritesSynaptic inputsProximal segmentThin dendritesAwake animals
2008
Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons
Zhou W, Yan P, Wuskell J, Loew L, Antic S. Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons. European Journal Of Neuroscience 2008, 27: 923-936. PMID: 18279369, PMCID: PMC2715167, DOI: 10.1111/j.1460-9568.2008.06075.x.Peer-Reviewed Original ResearchConceptsBasilar dendritic treeBasal dendritesRat prefrontal cortexPyramidal neuronsAction potentialsDendritic treePrefrontal cortical pyramidal neuronsLayer 5 pyramidal neuronsPrefrontal cortexSodium action potentialsBackpropagating action potentialsCortical pyramidal neuronsAction potential backpropagationNeocortical pyramidal neuronsSomatic action potentialsCortical pyramidal cellsDistal dendritic segmentsHigh-frequency burstsVoltage-sensitive dye imaging techniqueAP backpropagationSynaptic contactsIndividual dendritic branchesPyramidal cellsNeuronal outputCalcium transients