2024
A spatially constrained independent component analysis jointly informed by structural and functional network connectivity
Fouladivanda M, Iraji A, Wu L, van Erp T, Belger A, Hawamdeh F, Pearlson G, Calhoun V. A spatially constrained independent component analysis jointly informed by structural and functional network connectivity. Network Neuroscience 2024, 1-31. DOI: 10.1162/netn_a_00398.Peer-Reviewed Original ResearchIntrinsic connectivity networksFunctional brain connectivityBrain connectivityStructural connectivityFunctional connectivityIndependent component analysisResting-state functional MRIAnalysis of group differencesBrain functional organizationFunctional network connectivityStructural-functional connectivityNeuroimaging studiesFunctional MRIWhole-brain tractographyGroup differencesRs-fMRIBrain disordersFunctional couplingSchizophreniaStatistical analysis of group differencesSubject levelFunctional organizationConnectivity networksBrainDiffusion-weighted MRIA Bayesian incorporated linear non-Gaussian acyclic model for multiple directed graph estimation to study brain emotion circuit development in adolescence
Zhang A, Zhang G, Cai B, Wilson T, Stephen J, Calhoun V, Wang Y. A Bayesian incorporated linear non-Gaussian acyclic model for multiple directed graph estimation to study brain emotion circuit development in adolescence. Network Neuroscience 2024, 8: 791-807. PMID: 39355441, PMCID: PMC11349030, DOI: 10.1162/netn_a_00384.Peer-Reviewed Original ResearchPhiladelphia Neurodevelopmental CohortEmotional circuitryFunctional connectivityBrain's emotional circuitryEmotion identification skillBrain network organizationIndividuals aged 8Emotional processingEmotion perceptionBrain circuitsNeurodevelopmental CohortFMRI dataCognitive developmentIdentification skillsEmotional changesAged 8Adolescent stageAdolescentsNetwork organizationGroup-specific patternsIntermodular connectionsEmotionsCircuit developmentAccurate performanceBrainFrequency modulation increases the specificity of time-resolved connectivity: A resting-state fMRI study
Faghiri A, Yang K, Faria A, Ishizuka K, Sawa A, Adali T, Calhoun V. Frequency modulation increases the specificity of time-resolved connectivity: A resting-state fMRI study. Network Neuroscience 2024, 8: 734-761. PMID: 39355435, PMCID: PMC11349031, DOI: 10.1162/netn_a_00372.Peer-Reviewed Original ResearchSliding window Pearson correlationTime-resolved networksSingle sideband modulationTime-resolved connectivityResting-state fMRI studiesSideband modulationFunctional magnetic resonance imagingFunctional network connectivityResting-state functional magnetic resonance imagingActivity time seriesTypical controlsFrequency modulationLow-frequency informationStateEpisode of psychosisNetwork connectivityHuman brainSub-corticalSuperior performanceFMRI studyCortical regionsEfficient federated learning for distributed neuroimaging data
Thapaliya B, Ohib R, Geenjaar E, Liu J, Calhoun V, Plis S. Efficient federated learning for distributed neuroimaging data. Frontiers In Neuroinformatics 2024, 18: 1430987. PMID: 39315000, PMCID: PMC11416982, DOI: 10.3389/fninf.2024.1430987.Peer-Reviewed Original ResearchFederated learningCommunication overheadsSparse modelModel sparsityClient siteTraining phaseAdolescent Brain Cognitive DevelopmentData sharingEfficient communicationLarge modelsLocal trainingResource capabilitiesDatasetCommunicationLearningSparsityActual dataOverheadsPrivacyNeuroimaging dataCognitive developmentDataScientific communitySharingLocal-structure-preservation and redundancy-removal-based feature selection method and its application to the identification of biomarkers for schizophrenia
Xing Y, Pearlson G, Kochunov P, Calhoun V, Du Y. Local-structure-preservation and redundancy-removal-based feature selection method and its application to the identification of biomarkers for schizophrenia. NeuroImage 2024, 299: 120839. PMID: 39251116, PMCID: PMC11491165, DOI: 10.1016/j.neuroimage.2024.120839.Peer-Reviewed Original ResearchConceptsSelection methodClassification accuracy gainsGraph-based regularizationHigh-dimensional dataFeature selection methodLocal structural informationSparse regularizationAblation studiesFeature subsetPublic datasetsFeature selectionClassification accuracyExperimental evaluationAccuracy gainsSelection techniquesNetwork connectivityData transformationSuperior performanceDatasetConvergence analysisStructural informationClassificationRegularizationFeaturesDisorder predictionNeurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework
DeRosa J, Friedman N, Calhoun V, Banich M. Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework. NeuroImage 2024, 299: 120827. PMID: 39245397, DOI: 10.1016/j.neuroimage.2024.120827.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAdolescent Brain Cognitive DevelopmentIndividual’s resting-state functional connectivityAdolescent Brain Cognitive Development StudyFunctional brain organizationMental health profilesMental health characteristicsRsFC dataBrain organizationFunctional connectivityDevelopmental trajectoriesChildren aged 9Emotional functioningCognitive developmentLate childhoodAged 9SubtypesAdolescentsHealth characteristicsHealth profileChildhoodA core tensor sparsity enhancement method for solving Tucker-2 model of multi-subject fMRI data
Han Y, Lin Q, Kuang L, Zhao B, Gong X, Cong F, Wang Y, Calhoun V. A core tensor sparsity enhancement method for solving Tucker-2 model of multi-subject fMRI data. Biomedical Signal Processing And Control 2024, 95: 106471. DOI: 10.1016/j.bspc.2024.106471.Peer-Reviewed Original ResearchTucker-2 modelMulti-subject fMRI dataFactor matricesCore tensorHalf-quadratic splittingTensor structure informationLow-rank constraintTensor sparsitySparsity constraintQuadratic splittingTask-related fMRI dataImprovement of accuracyEnhancement methodOrthogonality constraintsFMRI dataProcrustes solutionSimulated fMRI dataTucker-3 modelSparsityTemporal evidenceResting-state fMRI dataIdentity matrixDecomposition modelIntrinsic relationshipStructural informationJoint multi-site domain adaptation and multi-modality feature selection for the diagnosis of psychiatric disorders
Ji Y, Silva R, Adali T, Wen X, Zhu Q, Jiang R, Zhang D, Qi S, Calhoun V. Joint multi-site domain adaptation and multi-modality feature selection for the diagnosis of psychiatric disorders. NeuroImage Clinical 2024, 43: 103663. PMID: 39226701, DOI: 10.1016/j.nicl.2024.103663.Peer-Reviewed Original ResearchAssociations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging
Qiu L, Liang C, Kochunov P, Hutchison K, Sui J, Jiang R, Zhi D, Vergara V, Yang X, Zhang D, Fu Z, Bustillo J, Qi S, Calhoun V. Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging. Translational Psychiatry 2024, 14: 326. PMID: 39112461, PMCID: PMC11306356, DOI: 10.1038/s41398-024-03035-2.Peer-Reviewed Original ResearchConceptsFronto-limbic networkSalience networkAssociated with cognitionFronto-basal gangliaDevelopmental disordersBrain networksLimbic systemAlcohol useAssociated with alcohol useMultimodal brain networksTobacco useAssociation of alcoholPsychiatric disordersMultimodal neuroimagingDMNBrain featuresCognitionAlcohol/tobacco useDisordersAssociated with tobacco useDepressionSymptomsFunctional abnormalitiesAlcoholBrainAbsence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI.
Schönberg L, Mohamed A, Yu Q, Kwiatek R, Del Fante P, Calhoun V, Shan Z. Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI. Cerebrovascular And Brain Metabolism Reviews 2024, 271678x241270528. PMID: 39113421, DOI: 10.1177/0271678x241270528.Peer-Reviewed Original ResearchBlood oxygen level-dependentFunctional MRIME/CFS participantsHealthy controlsTask-based functional MRISymbol Digit Modalities TestFatigue syndromeRight postcentral gyrusTask functional MRIFMRI signal changesOxygen level-dependentMyalgic encephalomyelitis/chronic fatigue syndromeLeft primary motor cortexChronic fatigue syndromeTask blocksCognitive tasksPostcentral gyrusCognitive cortexBOLD adaptationNeurophysiological processesNeurophysiological mechanismsPrimary motor cortexLevel-dependentModal testingFatigue severityCognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population
Fu Z, Sui J, Iraji A, Liu J, Calhoun V. Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population. Molecular Psychiatry 2024, 1-12. PMID: 39085394, DOI: 10.1038/s41380-024-02683-6.Peer-Reviewed Original ResearchDynamic functional connectivity statesDynamic functional connectivityAdolescent Brain Cognitive DevelopmentCognitive performanceDynamic functional connectivity patternsSensory networksAnalysis of dynamic functional connectivityFunctional connectivity statesDefault-modeNeurological underpinningsAttention problemsPsychiatric relevanceFunctional connectivitySensorimotor networkMediation analysisCognitive developmentChild's brainBrain statesMental healthMental problemsBrain dynamicsSliding-window approachMental behaviorBrainCerebellum4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia
Pusuluri K, Fu Z, Miller R, Pearlson G, Kochunov P, Van Erp T, Iraji A, Calhoun V. 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia. Human Brain Mapping 2024, 45: e26773. PMID: 39045900, PMCID: PMC11267451, DOI: 10.1002/hbm.26773.Peer-Reviewed Original ResearchConceptsBrain networksFunctional magnetic resonance imagingAssociated with cognitive performanceDynamics of functional brain networksAssociated with cognitionFunctional brain networksVoxel-wise changesVolumetric couplingDynamical variablesCognitive performanceTypical controlsSchizophreniaCognitive impairmentNetwork pairsMagnetic resonance imagingPair of networksCognitionAtypical variabilityResonance imagingCouplingNetwork connectivityNetwork growthImpairmentBrainStatic networksConstrained Independent Vector Analysis with Reference for Multi-Subject fMRI Analysis
Vu T, Laport F, Yang H, Calhoun V, Adal T. Constrained Independent Vector Analysis with Reference for Multi-Subject fMRI Analysis. IEEE Transactions On Biomedical Engineering 2024, PP: 1-12. PMID: 39042541, DOI: 10.1109/tbme.2024.3432273.Peer-Reviewed Original ResearchIndependent vector analysisIndependent component analysisIVA approachesIndependent vector analysis algorithmMulti-subject functional magnetic resonance imagingHigher-order statistical informationMulti-subject dataSingle-subject mappingModel interferenceMultiple datasetsPrior informationNovel methodStatistical dependenceDatasetSeparation qualityStatistical informationComputational issuesVariable thresholdAlgorithmStatistical diversityModel matchingVector analysisQuality of separationComponent analysisInformationDynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence
Treves I, Marusak H, Decker A, Kucyi A, Hubbard N, Bauer C, Leonard J, Grotzinger H, Giebler M, Torres Y, Imhof A, Romeo R, Calhoun V, Gabrieli J. Dynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence. Biological Psychiatry Global Open Science 2024, 4: 100367. PMID: 39286525, PMCID: PMC11402920, DOI: 10.1016/j.bpsgos.2024.100367.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingTrait mindfulnessFunctional connectivity analysisDynamic functional connectivity analysisBrain statesConnectivity analysisSelf-reported trait mindfulnessResting-state fMRI scansHigher trait mindfulnessPresent-moment experienceFunctional connectivity correlatesDynamic brain statesStatic functional connectivityState-of-mindTest-retest reliabilityAdolescent anxietyFMRI scanningNeural basisPsychiatric disordersDepressive symptomsNeural mechanismsLower anxietyFunctional connectivityEarly adolescenceConnectivity correlationsEffects of endogenous testosterone on oscillatory activity during verbal working memory in youth
Killanin A, Ward T, Embury C, Calhoun V, Wang Y, Stephen J, Picci G, Heinrichs‐Graham E, Wilson T. Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth. Human Brain Mapping 2024, 45: e26774. PMID: 38949599, PMCID: PMC11215982, DOI: 10.1002/hbm.26774.Peer-Reviewed Original ResearchConceptsVerbal working memoryVerbal working memory processingWorking memory processesWorking memoryEffects of chronological ageEndogenous testosterone levelsMemory processesOscillatory activitySternberg verbal working memory taskEffects of testosteroneLeft-lateralized language networkVerbal working memory taskAlpha oscillationsSalivary testosterone samplesWorking memory encodingWorking memory taskLeft temporal cortexRight cerebellar cortexNeural oscillatory activitySignificant oscillatory responsesNeural oscillatory dynamicsHuman brain structureCerebellar cortexYouth aged 6Chronological ageIdentifying EEG Biomarkers of Depression with Novel Explainable Deep Learning Architectures
Ellis C, Sancho M, Miller R, Calhoun V. Identifying EEG Biomarkers of Depression with Novel Explainable Deep Learning Architectures. Communications In Computer And Information Science 2024, 2156: 102-124. DOI: 10.1007/978-3-031-63803-9_6.Peer-Reviewed Original ResearchDeep learning modelsExplainability methodsExplainability analysisConvolutional neural network architectureLearning modelsRaw electroencephalogramNeural network architectureDeep learning architectureMajor depressive disorderLearning architectureNetwork architectureDeep learningModel architectureMultichannel electroencephalogramTraining approachArchitectureBiomarkers of depressionFrequency bandElectroencephalogramResearch contextDepressive disorderElectroencephalogram biomarkerAccuracyRight hemisphereExplainabilityA new transfer entropy method for measuring directed connectivity from complex-valued fMRI data
Li W, Lin Q, Zhang C, Han Y, Calhoun V. A new transfer entropy method for measuring directed connectivity from complex-valued fMRI data. Frontiers In Neuroscience 2024, 18: 1423014. PMID: 39050665, PMCID: PMC11266018, DOI: 10.3389/fnins.2024.1423014.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFMRI dataBrain regionsAnatomical Automatic LabelingTransfer entropyFunctional magnetic resonance imaging dataConnectivity of brain regionsFrontal-parietal regionsConsistent with previous findingsSignificant group differencesRight frontal-parietal regionPartial transfer entropyPredicting mental disordersMental disordersParietal regionsGroup differencesMagnitude effectExperimental fMRI dataDirectional connectivityComplex-valued fMRI dataSchizophreniaMagnetic resonance imagingComplex-valued approachEntropyMagnitude dataAssociation between the oral microbiome and brain resting state connectivity in schizophrenia
Lin D, Fu Z, Liu J, Perrone-Bizzozero N, Hutchison K, Bustillo J, Du Y, Pearlson G, Calhoun V. Association between the oral microbiome and brain resting state connectivity in schizophrenia. Schizophrenia Research 2024, 270: 392-402. PMID: 38986386, DOI: 10.1016/j.schres.2024.06.045.Peer-Reviewed Original ResearchOral microbiomeMicrobial speciesArea under curveResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingMicrobial 16S rRNA sequencingBrain circuit dysfunctionHealthy controlsBrain functional connectivity alterationsFunctional connectivity alterationsFunctional neuroimaging techniquesHypothalamic-pituitary-adrenal axisBrain functional connectivityFunctional network connectivityBrain functional activityBrain functional network connectivityHealthy control subjectsNeurotransmitter signaling pathwaysBeta diversityMicrobiome communitiesOral microbiome dysbiosisRRNA sequencingCircuit dysfunctionConnectivity alterationsSchizophreniaNeuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade
Du Y, Niu J, Xing Y, Li B, Calhoun V. Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade. Schizophrenia Bulletin 2024, sbae110. PMID: 38982882, DOI: 10.1093/schbul/sbae110.Peer-Reviewed Original ResearchArtificial intelligenceSemi-supervised learning methodArtificial intelligence techniquesAccurate diagnosis of SZMultimodal fusionAccurate diagnosis of schizophreniaIntelligence techniquesAI methodsLearning methodsDiagnosis of SZMental disordersSelection methodUnsupervised clusteringMagnetic resonance imagingBiomarker extractionDiagnosis of schizophreniaMulti-modal deep learning from imaging genomic data for schizophrenia classification
Kanyal A, Mazumder B, Calhoun V, Preda A, Turner J, Ford J, Ye D. Multi-modal deep learning from imaging genomic data for schizophrenia classification. Frontiers In Psychiatry 2024, 15: 1384842. PMID: 39006822, PMCID: PMC11239396, DOI: 10.3389/fpsyt.2024.1384842.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsGenomic dataGenetic markersGenomic markersBrains of individualsNucleotide polymorphismsEtiology of SZFunctional magnetic resonance imagingStructural magnetic resonance imagingMorphological featuresLayerwise relevance propagationHereditary aspectsHealthy controlsMarkers