2024
4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia
Pusuluri K, Fu Z, Miller R, Pearlson G, Kochunov P, Van Erp T, Iraji A, Calhoun V. 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia. Human Brain Mapping 2024, 45: e26773. PMID: 39045900, PMCID: PMC11267451, DOI: 10.1002/hbm.26773.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCognitive DysfunctionConnectomeFemaleHumansMagnetic Resonance ImagingMaleNerve NetSchizophreniaYoung AdultConceptsBrain networksFunctional magnetic resonance imagingAssociated with cognitive performanceDynamics of functional brain networksAssociated with cognitionFunctional brain networksVoxel-wise changesVolumetric couplingDynamical variablesCognitive performanceTypical controlsSchizophreniaCognitive impairmentNetwork pairsMagnetic resonance imagingPair of networksCognitionAtypical variabilityResonance imagingCouplingNetwork connectivityNetwork growthImpairmentBrainStatic networksA confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity
Hassanzadeh R, Abrol A, Pearlson G, Turner J, Calhoun V. A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity. PLOS ONE 2024, 19: e0293053. PMID: 38768123, PMCID: PMC11104643, DOI: 10.1371/journal.pone.0293053.Peer-Reviewed Original ResearchConceptsResting-state functional network connectivityFunctional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingAlzheimer's diseaseClassification of schizophreniaNetwork pairsPatients to healthy controlsSchizophrenia patientsNeurobiological mechanismsSZ patientsSubcortical networksCerebellum networkSchizophreniaRs-fMRIDisorder developmentMotor networkCompare patient groupsSubcortical domainSZ disorderHealthy controlsMagnetic resonance imagingDisordersNetwork connectivityFunctional abnormalitiesCross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia
Zhao C, Jiang R, Bustillo J, Kochunov P, Turner J, Liang C, Fu Z, Zhang D, Qi S, Calhoun V. Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia. Human Brain Mapping 2024, 45: e26694. PMID: 38727014, PMCID: PMC11083889, DOI: 10.1002/hbm.26694.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive DysfunctionCohort StudiesConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetSchizophreniaYoung AdultConceptsFunctional magnetic resonance imagingNegative symptomsFunctional connectivityCognitive impairmentPrediction of negative symptomsResting-state functional connectivityAssociated with reduced cognitive functionDebilitating mental illnessHealthy controlsPredicting functional connectivityEarly adulthood onsetPositive symptomsNeural underpinningsSchizophreniaCognitive functionSensorimotor networkPredicting symptomsMental illnessConnectivity patternsClinical interventionsMagnetic resonance imagingAdulthood onsetSymptomsImpairmentResonance imagingIntra-Atlas Node Size Effects on Graph Metrics in fMRI Data: Implications for Alzheimer’s Disease and Cognitive Impairment
Kolla S, Falakshahi H, Abrol A, Fu Z, Calhoun V. Intra-Atlas Node Size Effects on Graph Metrics in fMRI Data: Implications for Alzheimer’s Disease and Cognitive Impairment. Sensors 2024, 24: 814. PMID: 38339531, PMCID: PMC10857295, DOI: 10.3390/s24030814.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBiomarkersBrainBrain MappingCognitive DysfunctionHumansMagnetic Resonance ImagingConceptsGraph metricsFunctional network connectivityIndependent component analysisResting state fMRI dataData-driven methodologyNetwork connectivityNovel metricFunctional nodesNode sizeNodesLocal graph metricsMetricsNode dimensionsGraphAlzheimer's diseaseMild cognitive impairmentNetwork neuroscienceNeuroimaging researchNeuroimaging investigations
2023
Interpretable LSTM model reveals transiently-realized patterns of dynamic brain connectivity that predict patient deterioration or recovery from very mild cognitive impairment
Gao Y, Lewis N, Calhoun V, Miller R. Interpretable LSTM model reveals transiently-realized patterns of dynamic brain connectivity that predict patient deterioration or recovery from very mild cognitive impairment. Computers In Biology And Medicine 2023, 161: 107005. PMID: 37211004, PMCID: PMC10365638, DOI: 10.1016/j.compbiomed.2023.107005.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBiomarkersBrainCognitive DysfunctionHumansMagnetic Resonance ImagingNeurodegenerative DiseasesConceptsMild cognitive impairmentDynamic functional network connectivityCognitive impairmentResting-state functional magnetic resonance imagingDementia interventionsFunctional magnetic resonance imagingAlzheimer's diseaseCognitive healthPatient deteriorationFunctional network connectivityCognitive abilitiesShort-term memoryRs-fMRIBrain connectivityResolved measurementsDynamic brain connectivityMagnetic resonance imaging
2022
Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder
Qi S, Calhoun V, Zhang D, Miller J, Deng Z, Narr K, Sheline Y, McClintock S, Jiang R, Yang X, Upston J, Jones T, Sui J, Abbott C. Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder. BMC Medicine 2022, 20: 477. PMID: 36482369, PMCID: PMC9733153, DOI: 10.1186/s12916-022-02678-6.Peer-Reviewed Original ResearchMeSH KeywordsBrainCognitive DysfunctionDepressive Disorder, MajorElectroconvulsive TherapyHumansNeurobiologyConceptsMultimodal brain networksElectroconvulsive therapyBrain networksHippocampal complexCognitive impairmentSingle site clinical trialsCognitive impairing effectsSuperior orbitofrontal cortexECT seriesMedial temporal cortexLate-life depressionHDRS reductionAntidepressant outcomesOrbitofrontal cortexNeurobiological underpinningsCognitive safetyImpairing effectsTemporal cortexOptimal pulse amplitudeCognitive outcomesCognitive AssessmentCognitive-impairmentLongitudinal multimodal imagingCognitive networksDepression