2024
A spatially constrained independent component analysis jointly informed by structural and functional network connectivity
Fouladivanda M, Iraji A, Wu L, van Erp T, Belger A, Hawamdeh F, Pearlson G, Calhoun V. A spatially constrained independent component analysis jointly informed by structural and functional network connectivity. Network Neuroscience 2024, 1-31. DOI: 10.1162/netn_a_00398.Peer-Reviewed Original ResearchIntrinsic connectivity networksFunctional brain connectivityBrain connectivityStructural connectivityFunctional connectivityIndependent component analysisResting-state functional MRIAnalysis of group differencesBrain functional organizationFunctional network connectivityStructural-functional connectivityNeuroimaging studiesFunctional MRIWhole-brain tractographyGroup differencesRs-fMRIBrain disordersFunctional couplingSchizophreniaStatistical analysis of group differencesSubject levelFunctional organizationConnectivity networksBrainDiffusion-weighted MRIA Bayesian incorporated linear non-Gaussian acyclic model for multiple directed graph estimation to study brain emotion circuit development in adolescence
Zhang A, Zhang G, Cai B, Wilson T, Stephen J, Calhoun V, Wang Y. A Bayesian incorporated linear non-Gaussian acyclic model for multiple directed graph estimation to study brain emotion circuit development in adolescence. Network Neuroscience 2024, 8: 791-807. PMID: 39355441, PMCID: PMC11349030, DOI: 10.1162/netn_a_00384.Peer-Reviewed Original ResearchPhiladelphia Neurodevelopmental CohortEmotional circuitryFunctional connectivityBrain's emotional circuitryEmotion identification skillBrain network organizationIndividuals aged 8Emotional processingEmotion perceptionBrain circuitsNeurodevelopmental CohortFMRI dataCognitive developmentIdentification skillsEmotional changesAged 8Adolescent stageAdolescentsNetwork organizationGroup-specific patternsIntermodular connectionsEmotionsCircuit developmentAccurate performanceBrainNeurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework
DeRosa J, Friedman N, Calhoun V, Banich M. Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework. NeuroImage 2024, 299: 120827. PMID: 39245397, DOI: 10.1016/j.neuroimage.2024.120827.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAdolescent Brain Cognitive DevelopmentIndividual’s resting-state functional connectivityAdolescent Brain Cognitive Development StudyFunctional brain organizationMental health profilesMental health characteristicsRsFC dataBrain organizationFunctional connectivityDevelopmental trajectoriesChildren aged 9Emotional functioningCognitive developmentLate childhoodAged 9SubtypesAdolescentsHealth characteristicsHealth profileChildhoodCognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population
Fu Z, Sui J, Iraji A, Liu J, Calhoun V. Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population. Molecular Psychiatry 2024, 1-12. PMID: 39085394, DOI: 10.1038/s41380-024-02683-6.Peer-Reviewed Original ResearchDynamic functional connectivity statesDynamic functional connectivityAdolescent Brain Cognitive DevelopmentCognitive performanceDynamic functional connectivity patternsSensory networksAnalysis of dynamic functional connectivityFunctional connectivity statesDefault-modeNeurological underpinningsAttention problemsPsychiatric relevanceFunctional connectivitySensorimotor networkMediation analysisCognitive developmentChild's brainBrain statesMental healthMental problemsBrain dynamicsSliding-window approachMental behaviorBrainCerebellumDynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence
Treves I, Marusak H, Decker A, Kucyi A, Hubbard N, Bauer C, Leonard J, Grotzinger H, Giebler M, Torres Y, Imhof A, Romeo R, Calhoun V, Gabrieli J. Dynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence. Biological Psychiatry Global Open Science 2024, 4: 100367. PMID: 39286525, PMCID: PMC11402920, DOI: 10.1016/j.bpsgos.2024.100367.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingTrait mindfulnessFunctional connectivity analysisDynamic functional connectivity analysisBrain statesConnectivity analysisSelf-reported trait mindfulnessResting-state fMRI scansHigher trait mindfulnessPresent-moment experienceFunctional connectivity correlatesDynamic brain statesStatic functional connectivityState-of-mindTest-retest reliabilityAdolescent anxietyFMRI scanningNeural basisPsychiatric disordersDepressive symptomsNeural mechanismsLower anxietyFunctional connectivityEarly adolescenceConnectivity correlationsThe dynamics of dynamic time warping in fMRI data: A method to capture inter-network stretching and shrinking via warp elasticity
Wiafe S, Faghiri A, Fu Z, Miller R, Preda A, Calhoun V. The dynamics of dynamic time warping in fMRI data: A method to capture inter-network stretching and shrinking via warp elasticity. Imaging Neuroscience 2024, 2: 1-23. DOI: 10.1162/imag_a_00187.Peer-Reviewed Original ResearchDynamic time warpingDynamics of brain networksBrain networksBrain network interactionsFunctional magnetic resonance imagingFunctional connectivity measuresComplexity of brain functionDiverse timescalesTime warpingBrain dynamicsVisual cortexFunctional magnetic resonance imaging dataTimescalesFunctional connectivityBrain connectivityCoupled stretchingCouplingDynamic time warping methodBrain regionsTransient couplingConnectivity measuresFunctional connectivity metricsNeuroimaging researchCluster centroidsIntricate dynamicsExplainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment
Patel B, Orlichenko A, Patel A, Qu G, Wilson T, Stephen J, Calhoun V, Wang Y. Explainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment. Applied Sciences 2024, 14: 4144. DOI: 10.3390/app14104144.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBlood oxygen level-dependentGraph isomorphism networkGraph neural networksBrain networksFunctional magnetic resonance imaging paradigmFunctional magnetic resonance imaging blood oxygen level-dependentSex differencesClassification accuracyExploration of sex differencesInterpreting sex differencesOxygen level-dependentState-of-the-art algorithmsAdolescent neurodevelopmentState-of-the-artNeuropsychiatric conditionsFunctional connectivityTask-related dataDeep learning modelsLevel-dependentMouth movementsFMRI datasetsFunctional networksGraph structureAdolescentsCross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia
Zhao C, Jiang R, Bustillo J, Kochunov P, Turner J, Liang C, Fu Z, Zhang D, Qi S, Calhoun V. Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia. Human Brain Mapping 2024, 45: e26694. PMID: 38727014, PMCID: PMC11083889, DOI: 10.1002/hbm.26694.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNegative symptomsFunctional connectivityCognitive impairmentPrediction of negative symptomsResting-state functional connectivityAssociated with reduced cognitive functionDebilitating mental illnessHealthy controlsPredicting functional connectivityEarly adulthood onsetPositive symptomsNeural underpinningsSchizophreniaCognitive functionSensorimotor networkPredicting symptomsMental illnessConnectivity patternsClinical interventionsMagnetic resonance imagingAdulthood onsetSymptomsImpairmentResonance imagingInterpretable Cognitive Ability Prediction: A Comprehensive Gated Graph Transformer Framework for Analyzing Functional Brain Networks
Qu G, Orlichenko A, Wang J, Zhang G, Xiao L, Zhang K, Wilson T, Stephen J, Calhoun V, Wang Y. Interpretable Cognitive Ability Prediction: A Comprehensive Gated Graph Transformer Framework for Analyzing Functional Brain Networks. IEEE Transactions On Medical Imaging 2024, 43: 1568-1578. PMID: 38109241, PMCID: PMC11090410, DOI: 10.1109/tmi.2023.3343365.Peer-Reviewed Original ResearchConceptsGraph transformation frameworkBrain imaging datasetsFunctional brain networksPhiladelphia Neurodevelopmental CohortConvolutional deep learningFeature embeddingPropagation weightsGraph embeddingHuman Connectome ProjectAttention mechanismImage datasetsDeep learningGraph transformationFunctional connectivityAnalyze functional brain networksTransformation frameworkDiffusion strategyBrain networksPositional encodingSpatial knowledgePrediction accuracyIndividual cognitive abilitiesEmbeddingNetworkGraphComplexity Measures of Psychotic Brain Activity In The FMRI Signal
Li Q, Seraji M, Calhoun V, Iraji A. Complexity Measures of Psychotic Brain Activity In The FMRI Signal. 2024, 00: 9-12. DOI: 10.1109/ssiai59505.2024.10508702.Peer-Reviewed Original ResearchBrain activityPsychotic brainBrain regionsFunctional connectivityCharacteristics of psychiatric disordersAtypical brain activityNeural activity patternsFuzzy recurrence plotsPsychiatric disordersFMRI signalsComplexity measuresRecurrence plotsActivity patternsBrainEntropySample entropyFMRIImage analysisNonlinear dynamical systemsA Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age
Saha R, Saha D, Rahaman A, Fu Z, Liu J, Calhoun V. A Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age. Brain Connectivity 2024, 14: 130-140. PMID: 38308475, PMCID: PMC10954605, DOI: 10.1089/brain.2023.0040.Peer-Reviewed Original ResearchFunctional network connectivityFunctional connectivityPsychiatric problemsFunctional network connectivity matricesNetwork connectivityMultivariate patternsWhole-brain functional networksIntrinsic functional connectivityPattern of functional changesBrain functional connectivityIntrinsic functional relationshipLongitudinal changesAdolescent brainAge-related changesBrain networksStudy developmental changesScanning sessionBrain functionAssociated with longitudinal changesCognitive scoresDevelopmental changesBrain developmentFunctional changesCognitionLongitudinal change patternsRevealing complex functional topology brain network correspondences between humans and marmosets
Li Q, Calhoun V, Iraji A. Revealing complex functional topology brain network correspondences between humans and marmosets. Neuroscience Letters 2024, 822: 137624. PMID: 38218321, DOI: 10.1016/j.neulet.2024.137624.Peer-Reviewed Original ResearchConceptsWhole-brain functional connectivityFunctional brain connectivityDorsal attention networkFunctional connectivity patternsBrain connectivityMarmoset monkey brainBrain networksTopological characteristicsMode networkFunctional connectivityCognitive functionVisual networkNon-human primatesMonkey brainAttention networkConnectivity patternsNeural connectionsBrainFunctional correspondenceConnectome
2023
Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study
Zhi D, Jiang R, Pearlson G, Fu Z, Qi S, Yan W, Feng A, Xu M, Calhoun V, Sui J. Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study. Biological Psychiatry 2023, 95: 828-838. PMID: 38151182, PMCID: PMC11006588, DOI: 10.1016/j.biopsych.2023.12.019.Peer-Reviewed Original ResearchFunctional network connectivityCognitive abilitiesABCD studyMental healthLongitudinal predictionBehavioral developmentSleep problemsBrain functional network connectivityHigher cognitive abilitiesDefault mode networkChildren's behavioral developmentUnique protective factorsBrain functional connectivityCognitive controlTriple interactionFamily conflictMode networkMediation analysisFunctional connectivityInfluence behaviorFunctional networksProtective factorsSchool environmentChildhood developmentEnvironmental exposuresTheta oscillatory dynamics serving cognitive control index psychosocial distress in youth
Schantell M, Taylor B, Mansouri A, Arif Y, Coutant A, Rice D, Wang Y, Calhoun V, Stephen J, Wilson T. Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth. Neurobiology Of Stress 2023, 29: 100599. PMID: 38213830, PMCID: PMC10776433, DOI: 10.1016/j.ynstr.2023.100599.Peer-Reviewed Original ResearchMiddle cingulate cortexCognitive controlNIHTB-EBNational Institute of Mental Health's Research Domain Criteria (RDoC) frameworkResearch Domain Criteria (RDoC) frameworkLeft dorsolateral prefrontal cortexNIH Toolbox emotion batteryCognitive interference effectCognitive control processesEriksen flanker taskDorsolateral prefrontal cortexOscillatory theta activityPsychosocial distressDistress indexDynamic functional connectivityExploratory factor analysisPediatric psychopathologyFlanker taskPrefrontal cortexEmotion BatteryCingulate cortexCognitive interferenceFunctional connectivityDlPFCTheta oscillationsMultimodal Fusion of Functional and Structural Data to Recognize Longitudinal Change Patterns in the Adolescent Brain
Saha R, Saha D, Fu Z, Silva R, Calhoun V. Multimodal Fusion of Functional and Structural Data to Recognize Longitudinal Change Patterns in the Adolescent Brain. 2023, 00: 1-5. DOI: 10.1109/bhi58575.2023.10313489.Peer-Reviewed Original ResearchFunctional network connectivityAdolescent brainPotential gender-related differencesBilateral sensorimotor cortexStructural magnetic resonance imagingMagnetic resonance imagingBrain functional connectivityGender-related differencesSensorimotor cortexLongitudinal change patternsGrey matter dataResonance imagingJoint independent component analysisLongitudinal changesFunctional connectivityBrain developmentBrain functionEntire brainBrain connectivityBrain connectionsBrain analysisBrainSensorimotor domainModalitiesSMRI dataChromatic fusion: Generative multimodal neuroimaging data fusion provides multi‐informed insights into schizophrenia
Geenjaar E, Lewis N, Fedorov A, Wu L, Ford J, Preda A, Plis S, Calhoun V. Chromatic fusion: Generative multimodal neuroimaging data fusion provides multi‐informed insights into schizophrenia. Human Brain Mapping 2023, 44: 5828-5845. PMID: 37753705, PMCID: PMC10619380, DOI: 10.1002/hbm.26479.Peer-Reviewed Original ResearchDeep learning with explainability for characterizing age-related intrinsic differences in dynamic brain functional connectivity
Qiao C, Gao B, Liu Y, Hu X, Hu W, Calhoun V, Wang Y. Deep learning with explainability for characterizing age-related intrinsic differences in dynamic brain functional connectivity. Medical Image Analysis 2023, 90: 102941. PMID: 37683445, DOI: 10.1016/j.media.2023.102941.Peer-Reviewed Original ResearchFunctional connectivityBrain functional connectivityBrain networksDynamic brain functional connectivityDeep networksFunctional brain networksInformation processing abilityBrain development studiesEmotional processingDeep learning approachFeature selection strategyMachine learning modelsProcessing abilityBrain developmentCognitive activityDeep learningAccuracy-orientedSound processingBrainDevelopmental patternsLearning approachLearning modelsMental regulationSelection strategyInformation transmission mechanismExtracting functional connectivity brain networks at the resting state from pulsed arterial spin labeling data
Wiseman N, Iraji A, Haacke E, Calhoun V, Kou Z. Extracting functional connectivity brain networks at the resting state from pulsed arterial spin labeling data. Meta-Radiology 2023, 1: 100023. PMID: 38298860, PMCID: PMC10830167, DOI: 10.1016/j.metrad.2023.100023.Peer-Reviewed Original ResearchDefault mode networkMild traumatic brain injuryBrain networksRsfMRI dataFunctional connectivity brain networksResting state networksArterial spin labelingMild traumatic brain injury patientsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsFunctional connectivity informationBlood oxygen levelTraumatic brain injuryBOLD signalMode networkFunctional connectivitySpin labelingBlood flow changesMagnetic resonance imagingNeuronal activityResponse to activationPulsed ASLBOLDRetrospective studyPsychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls
Allen C, Maurer J, Gullapalli A, Edwards B, Aharoni E, Harenski C, Anderson N, Harenski K, Calhoun V, Kiehl K. Psychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls. Frontiers In Neuroimaging 2023, 2: 1216494. PMID: 37554634, PMCID: PMC10406221, DOI: 10.3389/fnimg.2023.1216494.Peer-Reviewed Original ResearchAmplitude of low-frequency fluctuationPsychopathic traitsResting-state networksLow-frequency fluctuationsAssociation of psychopathic traitsCorrelates of psychopathic traitsIncarcerated adolescent girlsResting-state fMRI scansResting-state functional connectivityElevated psychopathic traitsCognitive control networkGroup independent component analysisMode network componentsInter-network connectivityIntra-network connectivityHigh-risk adolescent girlsIndependent component analysisResting-state measuresFunctional network propertiesAdolescent girlsFMRI scanningParalimbic regionsMode networkIncarcerated boysFunctional connectivityFunctional and Structural Longitudinal Change Patterns in Adolescent Brain
Saha R, Saha D, Fu Z, Silva R, Calhoun V. Functional and Structural Longitudinal Change Patterns in Adolescent Brain. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-4. PMID: 38082649, DOI: 10.1109/embc40787.2023.10340079.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingStructural magnetic resonance imagingFunctional network connectivityWhole-brainGray matterBrain functional magnetic resonance imagingMagnetic resonance imagingAdolescent brainFunctional connectivityResonance imagingMultivariate patternsLongitudinal change patternsUnivariate changesAdolescentsLongitudinal changesBrainIncreasing ageFunctional changesComplementary techniquesNetwork connectivity