2024
Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging
Qiu L, Liang C, Kochunov P, Hutchison K, Sui J, Jiang R, Zhi D, Vergara V, Yang X, Zhang D, Fu Z, Bustillo J, Qi S, Calhoun V. Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging. Translational Psychiatry 2024, 14: 326. PMID: 39112461, PMCID: PMC11306356, DOI: 10.1038/s41398-024-03035-2.Peer-Reviewed Original ResearchConceptsFronto-limbic networkSalience networkAssociated with cognitionFronto-basal gangliaDevelopmental disordersBrain networksLimbic systemAlcohol useAssociated with alcohol useMultimodal brain networksTobacco useAssociation of alcoholPsychiatric disordersMultimodal neuroimagingDMNBrain featuresCognitionAlcohol/tobacco useDisordersAssociated with tobacco useDepressionSymptomsFunctional abnormalitiesAlcoholBrainThe brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-upCross-continental environmental and genome-wide association study on children and adolescent anxiety and depression
Thapaliya B, Ray B, Farahdel B, Suresh P, Sapkota R, Holla B, Mahadevan J, Chen J, Vaidya N, Perrone-Bizzozero N, Benegal V, Schumann G, Calhoun V, Liu J. Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression. Frontiers In Psychiatry 2024, 15: 1384298. PMID: 38827440, PMCID: PMC11141390, DOI: 10.3389/fpsyt.2024.1384298.Peer-Reviewed Original ResearchEarly life stressAdolescent anxietyLife stressMega-analysisCognitive Development StudyHypothalamic-pituitary-adrenal axisSupport IndexAssociated with anxietyRisk of anxietyExternalizing disordersAdolescent brainGenome-wide association studiesGenetic vulnerabilityAnxietyGenome-wide association analysisPublic health concernDepressionMental healthLinear mixed-effects modelsEnvironmental factorsMixed-effects modelsAssociation studiesTissue enrichment analysisGenetic associationGenomic significance
2022
Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder
Qi S, Calhoun V, Zhang D, Miller J, Deng Z, Narr K, Sheline Y, McClintock S, Jiang R, Yang X, Upston J, Jones T, Sui J, Abbott C. Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder. BMC Medicine 2022, 20: 477. PMID: 36482369, PMCID: PMC9733153, DOI: 10.1186/s12916-022-02678-6.Peer-Reviewed Original ResearchConceptsMultimodal brain networksElectroconvulsive therapyBrain networksHippocampal complexCognitive impairmentSingle site clinical trialsCognitive impairing effectsSuperior orbitofrontal cortexECT seriesMedial temporal cortexLate-life depressionHDRS reductionAntidepressant outcomesOrbitofrontal cortexNeurobiological underpinningsCognitive safetyImpairing effectsTemporal cortexOptimal pulse amplitudeCognitive outcomesCognitive AssessmentCognitive-impairmentLongitudinal multimodal imagingCognitive networksDepression