2024
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behavior
2021
Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficits
2020
Functional neural network configuration in late childhood varies by age and cognitive state
Le TM, Huang AS, O’Rawe J, Leung HC. Functional neural network configuration in late childhood varies by age and cognitive state. Developmental Cognitive Neuroscience 2020, 45: 100862. PMID: 32920279, PMCID: PMC7494462, DOI: 10.1016/j.dcn.2020.100862.Peer-Reviewed Original ResearchConceptsWhole-brain networksCognitive demandsLate childhoodConnectivity patternsFunctional network characteristicsFunctional network connectivityNetwork connectivity patternsPerceptual tasksFrontoparietal networkVisual processingCognitive developmentCognitive stateVisual perceptionBehavioral performanceTask statesEarly adolescenceBrain maturationConnectivity profilesDistinct tasksYoung adultsNeural network configurationMemoryNetwork architectureExploratory analysisTaskPerceived burdensomeness and neural responses to ostracism in the Cyberball task
Le TM, Zhornitsky S, Wang W, Li CR. Perceived burdensomeness and neural responses to ostracism in the Cyberball task. Journal Of Psychiatric Research 2020, 130: 1-8. PMID: 32763557, PMCID: PMC7554229, DOI: 10.1016/j.jpsychires.2020.06.015.Peer-Reviewed Original ResearchConceptsCyberball taskInterpersonal needsIndividual differencesProsocial behaviorNeural responsesSocial interactionStronger neural responsesGreater brain activationDorsomedial prefrontal cortexMiddle frontal gyrusSocial exclusionResponse timeBrain activationBrain correlatesBehavioral performanceFMRI studyAnterior insulaFrontal gyrusSocial painBehavioral avoidanceAffective responsesBehavioral measuresNeural activationPrefrontal cortexEmotional distress
2019
Neural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortex