2021
Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficits
2019
Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex
Le TM, Zhornitsky S, Wang W, Zhang S, Li C. Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex. Addiction Biology 2019, 26: e12857. PMID: 31746092, PMCID: PMC8627684, DOI: 10.1111/adb.12857.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismCuesFeeding BehaviorFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedPrefrontal CortexConceptsLateral orbitofrontal cortexAlcohol Use Disorders Identification TestGray matter volumeEffect of ProblemOrbitofrontal cortexWhole-brain multiple regressionLeft middle frontal gyrusAlcohol misuseFood cue responsesFunctional magnetic resonance imaging (fMRI) dataVisual food cuesAUDIT scoresMatter volumeMiddle frontal gyrusAffective processesNonfood cuesFood cuesNonfood imagesBrain substratesDisorders Identification TestFrontal gyrusNeural mechanismsFood stimuliCue responsesFood images
2017
Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder
Le TM, Borghi JA, Kujawa AJ, Klein DN, Leung HC. Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder. NeuroImage Clinical 2017, 14: 43-53. PMID: 28138426, PMCID: PMC5257188, DOI: 10.1016/j.nicl.2017.01.004.Peer-Reviewed Original ResearchConceptsVisual association areasMemory updatingPrefrontal cortexAssociation areasIrrelevant negative informationMajor depressive disorderPrefrontal cortical activityFunctional magnetic resonanceVisual cortical activationMDD groupCognitive controlNeutral facesEmotion processingTask stimuliGreater ruminationRecognition testCore clinical featuresPerformance deficitsRecognition taskNegative informationMore persistent activationAbnormal affectTask informationUnmedicated participantsCortical activation