2022
Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking
Le TM, Malone T, Li CR. Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking. Drug And Alcohol Dependence 2022, 231: 109248. PMID: 34998254, PMCID: PMC8881788, DOI: 10.1016/j.drugalcdep.2021.109248.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPositive alcohol expectanciesAlcohol expectanciesInsular connectivityFunctional connectivityWhole-brain multiple regressionPath analysisNegative emotion processingVentromedial prefrontal cortexSuperior parietal lobuleSuperior frontal gyrusCognitive controlAlcohol stimuliEmotion processingPrefrontal structuresStimulus saliencyFrontal gyrusDrinking motivationsMotivational circuitsInsula connectivityParietal lobuleAdult drinkersPrefrontal cortexInsulaDrinking behavior
2020
Perceived burdensomeness and neural responses to ostracism in the Cyberball task
Le TM, Zhornitsky S, Wang W, Li CR. Perceived burdensomeness and neural responses to ostracism in the Cyberball task. Journal Of Psychiatric Research 2020, 130: 1-8. PMID: 32763557, PMCID: PMC7554229, DOI: 10.1016/j.jpsychires.2020.06.015.Peer-Reviewed Original ResearchConceptsCyberball taskInterpersonal needsIndividual differencesProsocial behaviorNeural responsesSocial interactionStronger neural responsesGreater brain activationDorsomedial prefrontal cortexMiddle frontal gyrusSocial exclusionResponse timeBrain activationBrain correlatesBehavioral performanceFMRI studyAnterior insulaFrontal gyrusSocial painBehavioral avoidanceAffective responsesBehavioral measuresNeural activationPrefrontal cortexEmotional distress
2017
Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder
Le TM, Borghi JA, Kujawa AJ, Klein DN, Leung HC. Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder. NeuroImage Clinical 2017, 14: 43-53. PMID: 28138426, PMCID: PMC5257188, DOI: 10.1016/j.nicl.2017.01.004.Peer-Reviewed Original ResearchConceptsVisual association areasMemory updatingPrefrontal cortexAssociation areasIrrelevant negative informationMajor depressive disorderPrefrontal cortical activityFunctional magnetic resonanceVisual cortical activationMDD groupCognitive controlNeutral facesEmotion processingTask stimuliGreater ruminationRecognition testCore clinical featuresPerformance deficitsRecognition taskNegative informationMore persistent activationAbnormal affectTask informationUnmedicated participantsCortical activation