Btbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMice