Ketamine induces immediate and delayed alterations of OCD-like behavior
Thompson SL, Welch AC, Iourinets J, Dulawa SC. Ketamine induces immediate and delayed alterations of OCD-like behavior. Psychopharmacology 2020, 237: 627-638. PMID: 31927606, DOI: 10.1007/s00213-019-05397-8.Peer-Reviewed Original ResearchConceptsOCD-like behaviorPrepulse inhibitionTherapeutic effectH postinjectionNoncompetitive NMDA receptor antagonistOCD patientsAnti-OCD effectsRationaleObsessive-compulsive disorderNMDA receptor antagonistRapid therapeutic effectPretreatment time pointsAcute ketaminePharmacological monotherapyKetamine pretreatmentKetamine treatmentPPI deficitsReuptake inhibitorsReceptor antagonistLow doseMin postinjectionPsychiatric disordersDelayed alterationsResponse rateHigh dosesKetamine