Dissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice
Thompson SL, Dulawa SC. Dissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice. PLOS ONE 2019, 14: e0211239. PMID: 30721232, PMCID: PMC6363181, DOI: 10.1371/journal.pone.0211239.Peer-Reviewed Original ResearchConceptsPPI deficitsObsessive-compulsive disorderGSK-3 inhibitionΒ-arrestin2Perseverative behaviorInhibitory G protein-coupled receptorsGSK-3 inhibitorsPerseverative locomotor patternsG protein-coupled pathwaySerotonin 1B receptorG protein-coupled receptorsAcute pretreatmentAutism spectrum disorderAcute treatmentKO miceReceptor agonistOpen fieldKnockout miceBehavioral testingBiased ligandsReduced locomotionMiceGSK-3βInhibition deficitsModest reduction