2024
Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts
Visoki E, Moore T, Zhang X, Tran K, Ly C, Gataviņš M, DiDomenico G, Brogan L, Fein J, Warrier V, Guloksuz S, Barzilay R. Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts. JAMA Psychiatry 2024, 81: 1020-1029. PMID: 39018056, PMCID: PMC11255979, DOI: 10.1001/jamapsychiatry.2024.1887.Peer-Reviewed Original ResearchMillennium Cohort StudyExposome scoreLifestyle factorsAdolescent Brain Cognitive DevelopmentCohort studyExposome-wide association studyAssociated with suicide attemptsUK Millennium Cohort StudyNational longitudinal cohortSuicide attemptsProtective exposuresLogistic regression modelsFamily history of suicideRisk classificationAdolescent Brain Cognitive Development StudyUS hospitalsEnvironmental/lifestyle factorsEmergency departmentTest associationsHistory of suicidePopulation settingCause of deathUS adolescentsFamily historyLongitudinal cohort
2023
The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study
Erzin G, Atbaşoğlu C, Fusar-Poli L, Saka M, Üçok A, Alptekin K, Os J, Akay G, Gülöksüz S. The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study. European Psychiatry 2023, 66: s264-s264. PMCID: PMC10596217, DOI: 10.1192/j.eurpsy.2023.601.Peer-Reviewed Original ResearchMetabolic parametersHealthy controlsES-SCZHigh-density lipid levelsDiastolic blood pressureNational Schizophrenia NetworksExposome scorePhysical health outcomesBlood pressureAnalysis ageLipid levelsGlucose levelsGene-environment interactionsPsychosis developmentLinear regression analysisHealth outcomesPrenatal periodSchizophrenia NetworkSchizophreniaClinical implementationEnvironmental exposuresEUGEI studyNongenetic exposuresRegression analysisImportant metabolic parametersThe association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls
Erzin G, Atbaşoğlu C, Fusar-Poli L, Saka M, Üçok A, Alptekin K, Van Os J, Guloksuz S, Gümüş-Akay G. The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls. Neuroscience Applied 2023, 2: 103594. DOI: 10.1016/j.nsa.2023.103594.Peer-Reviewed Original Research
2022
Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
Paquin V, Pries L, ten Have M, Bak M, Gunther N, de Graaf R, van Dorsselaer S, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, van Os J, Shah J, Guloksuz S. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry And Psychiatric Epidemiology 2022, 58: 43-52. PMID: 35913550, PMCID: PMC9845157, DOI: 10.1007/s00127-022-02346-3.Peer-Reviewed Original ResearchConceptsSex-specific associationsSelf-reported healthPRS-SCZES-SCZPhysical healthGeneral populationNetherlands Mental Health SurveyIncidence Study-2Mental Health SurveyHealth SurveyRisk scoreAge 65Common genetic variantsHealth correlatesAge 18Poor healthOlder individualsMental healthPolygenic riskLinear mixed modelsAgeSexExposome scoreHealthAssociationLongitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study
Erzin G, Pries L, Dimitrakopoulos S, Ralli I, Xenaki L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Rizos E, Kollias K, Os J, Guloksuz S, Stefanis N. Longitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study. European Psychiatry 2022, 65: s760-s760. PMCID: PMC9567635, DOI: 10.1192/j.eurpsy.2022.1963.Peer-Reviewed Original ResearchPANSS total scoreFirst-episode psychosisClinical featuresES-SCZTotal scoreIllness coursePsychosis developmentLongitudinal associationsEnvironmental exposuresTime interactionNegative Syndrome ScaleExposome scoreEpisode psychosisSyndrome ScaleSymptom severitySchizophreniaEnvironmental predispositionMultilevel regression analysisScoresRegression analysisFollowPrevious reportsBaselineAssociationCurrent studyP507. Longitudinal Association Between Exposome Score for Schizophrenia and Clinical Features: Results From the Athens First-Episode Psychosis Research Study
Erzin G, Pries L, Dimitrakopoulos S, Ralli I, Xenaki L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Rizos E, Kollias K, van Os J, Stefanis N, Guloksuz S. P507. Longitudinal Association Between Exposome Score for Schizophrenia and Clinical Features: Results From the Athens First-Episode Psychosis Research Study. Biological Psychiatry 2022, 91: s293. DOI: 10.1016/j.biopsych.2022.02.744.Peer-Reviewed Original Research
2021
P.0157 Association between exposome score for schizophrenia and functioning in first-episode psychosis: results from the athens first-episode psychosis research study
Erzin G, Dimitrakopoulos S, Ralli I, Pries L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Kollias K, Os J, Guloksuz S, Stefanis N. P.0157 Association between exposome score for schizophrenia and functioning in first-episode psychosis: results from the athens first-episode psychosis research study. European Neuropsychopharmacology 2021, 53: s114-s115. DOI: 10.1016/j.euroneuro.2021.10.153.Peer-Reviewed Original ResearchAssociation between exposome score for schizophrenia and functioning in first-episode psychosis: results from the Athens first-episode psychosis research study
Erzin G, Pries L, Dimitrakopoulos S, Ralli I, Xenaki L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Rizos E, Kollias K, Van Os J, Guloksuz S, Stefanis N. Association between exposome score for schizophrenia and functioning in first-episode psychosis: results from the Athens first-episode psychosis research study. Psychological Medicine 2021, 53: 2609-2618. PMID: 34789350, PMCID: PMC10123830, DOI: 10.1017/s0033291721004542.Peer-Reviewed Original Research
2020
Predictive Performance of Exposome Score for Schizophrenia in the General Population
Pries L, Erzin G, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Guloksuz S. Predictive Performance of Exposome Score for Schizophrenia in the General Population. Schizophrenia Bulletin 2020, 47: 277-283. PMID: 33215211, PMCID: PMC7965069, DOI: 10.1093/schbul/sbaa170.Peer-Reviewed Original ResearchConceptsES-SCZOptimal cut pointGeneral populationPopulation cohortGeneral population cohortCut pointsExposome scoreSchizophrenia spectrum disordersMeta-analytical estimatesClinical outcomesRisk strataRisk stratificationMulticausal etiologyMedical outcomesPsychiatric diagnosisBipolar disorderSchizophrenia diagnosisExposure scoreSuicide planSum scoreGene-environment interaction studiesSchizophreniaRisk predictionCharacteristic curveScores