2024
The criminal justice system in alcohol use treatment: a nationwide analysis of racial disparities in treatment referral and completion
Stenersen M, Peltier M, McKee S. The criminal justice system in alcohol use treatment: a nationwide analysis of racial disparities in treatment referral and completion. Alcohol And Alcoholism 2024, 59: agad092. PMID: 38266072, PMCID: PMC10807701, DOI: 10.1093/alcalc/agad092.Peer-Reviewed Original ResearchConceptsCJ systemCriminal justiceCriminal justice systemReferral to alcohol treatmentAnalysis of racial disparitiesInfluence of raceJustice systemTreatment completionNative peopleTreatment Episode Dataset-DischargeImpact of raceCommunities of colorTreatment referralAlcohol treatmentAlcohol use treatmentSubstance useRacial inequalityRacial disparitiesScholarly literatureUse treatmentAmerican Indian/Alaska Native peopleUnited StatesSeries of ANOVAsAlcohol useRace
2022
Why language matters in alcohol research: Reducing stigma
Shi HD, McKee SA, Cosgrove KP. Why language matters in alcohol research: Reducing stigma. Alcohol Clinical And Experimental Research 2022, 46: 1103-1109. PMID: 35727299, PMCID: PMC9246863, DOI: 10.1111/acer.14840.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disordersTreatment outcomesPubMed CentralDrug use disordersQuality of careRate of treatmentAlcohol research communityManual searchWiley Online DatabaseAddictive disordersDisordersTreatment seekingAlcoholicsNational InstituteNIH fundingPercent useInternational SocietyTerminology guidelinesStigmatizing languageAlcohol researchStigmatizing mannerOutcomesUsing machine learning to predict heavy drinking during outpatient alcohol treatment
Roberts W, Zhao Y, Verplaetse T, Moore KE, Peltier MR, Burke C, Zakiniaeiz Y, McKee S. Using machine learning to predict heavy drinking during outpatient alcohol treatment. Alcohol Clinical And Experimental Research 2022, 46: 657-666. PMID: 35420710, PMCID: PMC9180421, DOI: 10.1111/acer.14802.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAlgorithmsEthanolFemaleHumansMachine LearningMaleOutpatientsTreatment OutcomeConceptsAlcohol use disorderHeavy drinkingTreatment outcomesInvasive assessment methodsOutpatient AUD treatmentLast monthOutpatient alcohol treatmentMultisite clinical trialAccurate clinical predictionsHeavy alcohol useSex differencesBi-weekly sessionsAlcohol treatment outcomesPatient characteristicsClinical outcomesClinical trialsClinical dataStratified analysisEffective treatmentPsychiatric disordersUse disordersAUD treatmentSubstantial sex differencesAlcohol treatmentFirst monthSex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways
Mineur YS, Garcia-Rivas V, Thomas MA, Soares AR, McKee SA, Picciotto MR. Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. Psychopharmacology 2022, 239: 2041-2061. PMID: 35359158, PMCID: PMC9704113, DOI: 10.1007/s00213-022-06120-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol intakeInflammatory pathwaysAlcohol drinkingStress-induced alcohol drinkingSex differencesSex-dependent effectsStress-induced alcoholEffects of stressPreclinical behavioral modelsAlcohol-dependent behaviorsMicroglial activationClinical studiesPreclinical studiesInflammatory signalingNeuronal functionAlcohol seekingIntakeFuture studiesDrinkingDifferencesAmygdalaPathwayStudyWomen
2021
Psychosocial function, legal involvement and violence in mental disorder
Buchanan A, Moore KE, Pittman B, McKee SA. Psychosocial function, legal involvement and violence in mental disorder. European Psychiatry 2021, 64: e75. PMID: 34859762, PMCID: PMC8715282, DOI: 10.1192/j.eurpsy.2021.2250.Peer-Reviewed Original ResearchConceptsPsychosocial functionAssociated Disabilities Interview Schedule-5Mental disordersWorse psychosocial functionDSM-5 categoriesAlcohol use disorderLongitudinal designSchedule 5Significant outcomesLegal involvementUse disordersPersonality disorderEffect sizeDrug abuseNational Epidemiologic SurveyAlcohol abuseMental illnessDisordersAbuseLifetime outcomesPeopleRepresentative sampleRelated conditionsSocial networksForm Health Survey version 2Prospective Associations of Pain Intensity and Substance Use in the United States Population: A Cross-Lagged Panel Analysis.
Roberts W, Moore KE, Verplaetse TL, Zakiniaeiz Y, Burke C, Peltier MR, McKee SA. Prospective Associations of Pain Intensity and Substance Use in the United States Population: A Cross-Lagged Panel Analysis. Journal Of Studies On Alcohol And Drugs 2021, 82: 576-583. PMID: 34546903, PMCID: PMC8819613, DOI: 10.15288/jsad.2021.82.576.Peer-Reviewed Original ResearchConceptsModerate drinking guidelinesPain intensitySubstance use outcomesSubsequent pain intensitySubstance useDrinking guidelinesUse outcomesProspective associationsLevel of painUse problemsHarmful substance usePositive prospective associationUnited States populationSubstance use problemsAlcohol use problemsReciprocal associationsHealth StudyRepresentative cohortCohort surveyPainAdult survey dataWeekly useHistory of useDemographic covariatesOutcomesSex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Verplaetse TL, Peltier MR, Roberts W, Burke C, Moore KE, Pittman B, McKee SA. Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Addictive Behaviors 2021, 123: 107055. PMID: 34311184, PMCID: PMC8419091, DOI: 10.1016/j.addbeh.2021.107055.Peer-Reviewed Original ResearchConceptsSignificant medical conditionsMedical conditionsNational Epidemiologic SurveyDSM-5 AUDRespiratory conditionsEpidemiologic SurveyAlcohol useU.S. National Epidemiologic SurveyRate of drinkingPresence of cancerAlcohol use disorderRelated Conditions-IIIHeavy alcohol useGreater health consequencesYears cancerProblematic alcohol useUse disordersOrgan systemsCancerHealth consequencesRelated conditionsEffective interventionsWomenConditions-IIISexGender and past year serious psychological distress are associated with past year AUD: Time-varying results from the National Survey on Drug Use and Health (NSDUH; 2008–2017)
Verplaetse TL, Peltier MR, Roberts W, Pittman B, McKee SA. Gender and past year serious psychological distress are associated with past year AUD: Time-varying results from the National Survey on Drug Use and Health (NSDUH; 2008–2017). Addictive Behaviors 2021, 116: 106815. PMID: 33450666, PMCID: PMC7887085, DOI: 10.1016/j.addbeh.2020.106815.Peer-Reviewed Original Research
2020
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years
Verplaetse TL, Cosgrove KP, Tanabe J, McKee SA. Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. Journal Of Neuroscience Research 2020, 99: 309-323. PMID: 32333417, PMCID: PMC7584757, DOI: 10.1002/jnr.24625.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol consumptionNarrative reviewBrain functionAlcohol useRisk of AUDMagnetic resonance imagingPositron emission tomographyDiffusion tensor imagingHigh-risk drinkingFunctional magnetic resonanceImaging outcomesSex/genderProblematic alcohol consumptionUse disordersResonance imagingEmission tomographySex/gender differencesRobust increaseTensor imagingBrain imaging researchRecent neuroimaging literatureWomenEvent-related potentialsNeurobiological underpinningsProspective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health
Roberts W, Verplaetse T, Peltier MKR, Moore KE, Gueorguieva R, McKee SA. Prospective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health. Addiction 2020, 115: 1571-1579. PMID: 31977106, PMCID: PMC7340560, DOI: 10.1111/add.14980.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesHazardous alcohol useE-cigarette useE-cigarettesCigarette useAlcohol useUse outcomesExposure groupCigarette usersTotal drinksSocio-demographic risk factorsUnited States adult populationWave 1Non-institutionalized adultsStates adult populationHarmful alcohol consumptionNon-daily useE-cigarette usersPoorer alcohol use outcomesSocio-demographic characteristicsRisk factorsHealth SurveyHigher oddsTobacco cigarettesAlcohol abuse
2019
Alcohol Abstainer Status and Prazosin Treatment in Association with Changes in Posttraumatic Stress Disorder Symptoms in Veterans with Comorbid Alcohol Use Disorder and Posttraumatic Stress Disorder
Verplaetse TL, Ralevski E, Roberts W, Gueorguieva R, McKee SA, Petrakis IL. Alcohol Abstainer Status and Prazosin Treatment in Association with Changes in Posttraumatic Stress Disorder Symptoms in Veterans with Comorbid Alcohol Use Disorder and Posttraumatic Stress Disorder. Alcohol Clinical And Experimental Research 2019, 43: 741-746. PMID: 30698839, PMCID: PMC6443463, DOI: 10.1111/acer.13969.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPosttraumatic stress disorderPlacebo-treated individualsTotal CAPS scoresClinical trialsCAPS scoresPrazosin treatmentComorbid populationPTSD symptomsUse disordersClinician-Administered PTSD Scale scoresDouble-blind clinical trialStress disorderComorbid alcohol use disorderPrazosin-treated groupSymptoms of PTSDRecent clinical trialsComorbid alcohol dependenceCourse of treatmentΑ1-adrenergic antagonistPosttraumatic stress disorder (PTSD) symptomsOngoing symptomsSleep disturbancesMedication effectsNoradrenergic systemHigh Risk of Alcohol-Impaired Driving in Adults With Comorbid Alcohol and Substance Use Disorders in the U.S. Population.
Roberts W, Moore KE, Pittman BP, Fillmore MT, McKee SA. High Risk of Alcohol-Impaired Driving in Adults With Comorbid Alcohol and Substance Use Disorders in the U.S. Population. Journal Of Studies On Alcohol And Drugs 2019, 80: 114-119. PMID: 30807283, PMCID: PMC6396510, DOI: 10.15288/jsad.2019.80.114.Peer-Reviewed Original ResearchConceptsSubstance use disordersAlcohol use disorderComorbid substance use disorderUse disordersSUD diagnosisHigh riskAssociated Disabilities Interview Schedule-5Alcohol-impaired drivingPast-year alcohol use disorderSubstance use comorbiditiesNational Epidemiologic SurveyDSM-5 criteriaAlcohol-impaired driving behaviorIncreased oddsComorbid alcoholQuantity/frequencyHigher oddsPast-year drinkersEpidemiologic SurveyRelated conditionsAUD severityU.S. populationDisordersOddsCannabis legalization
2018
Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population
Roberts W, Moore K, Peltier MR, Verplaetse TL, Oberleitner L, Hacker R, McKee SA. Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population. Alcohol Clinical And Experimental Research 2018, 42: 2385-2393. PMID: 30222189, PMCID: PMC6286236, DOI: 10.1111/acer.13889.Peer-Reviewed Original ResearchConceptsAlcohol use disorderE-cigarette useHarmful alcohol useE-cigarette usersHarmful alcohol consumptionAlcohol use outcomesElectronic cigarette useCigarette useAlcohol useE-cigarettesUse outcomesNondaily usersUse disordersAlcohol consumptionPast-year e-cigarette useHazardous drinkingAssociated Disabilities Interview ScheduleCigarette/e-cigarette useU.S. populationRelated Conditions Wave IIIDrinking frequencyTobacco cigarette useNational Epidemiologic SurveyBinge drinking frequencyQuantity/frequencyTobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking
Roberts W, Ralevski E, Verplaetse TL, McKee SA, Petrakis IL. Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. Journal Of Substance Use And Addiction Treatment 2018, 94: 91-96. PMID: 30243424, PMCID: PMC6154389, DOI: 10.1016/j.jsat.2018.08.015.Peer-Reviewed Original ResearchConceptsAlcohol use disorderClinical trialsSmoking outcomesNicotinic acetylcholine receptor antagonistAlcohol useHigh-dependence smokersEffects of mecamylamineSubgroups of smokersAcetylcholine receptor antagonistHigh tobacco dependencePlacebo groupMedication conditionReceptor antagonistMedication effectsTobacco dependenceTobacco useTreatment respondersMecamylamineSmokingTreatment phaseUse disordersAlcohol dependenceSmokersTrialsSignificant differencesMobile alcohol biosensors and pharmacotherapy development research
Roberts W, McKee SA. Mobile alcohol biosensors and pharmacotherapy development research. Alcohol 2018, 81: 149-160. PMID: 31679765, PMCID: PMC6842067, DOI: 10.1016/j.alcohol.2018.07.012.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAlcohol OxidoreductasesAlcoholismBiosensing TechniquesHumansMobile ApplicationsEffects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users
Roberts W, Shi JM, Tetrault JM, McKee SA. Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users. Journal Of Addiction Medicine 2018, 12: 227-233. PMID: 29438157, PMCID: PMC5970035, DOI: 10.1097/adm.0000000000000392.Peer-Reviewed Original ResearchConceptsLow-dose naltrexoneTobacco usersTreatment outcomesPlacebo-controlled human laboratory studySmoking cessation treatmentEffects of vareniclineCigarettes ad libitumHuman laboratory studiesSubjective drug effectsVarenicline monotherapyCessation medicationsMedication therapyCessation treatmentMedication armTobacco useVareniclineLow doseSmoking relapseSmokingDrug effectsSmoking outcomesSmoking behaviorNaltrexoneCarbon monoxide levelsHeavy drinkersEffects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes
Roberts W, McKee SA. Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes. Experimental And Clinical Psychopharmacology 2018, 26: 49-57. PMID: 29389170, PMCID: PMC5797996, DOI: 10.1037/pha0000161.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive functioningCognitive assessment batteryContinuous performance taskAdult heavy drinkersSignificant indirect effectUse disordersReaction timeEffects of vareniclinePerformance taskHeavy drinkersCognitive outcomesAssessment BatteryHuman laboratory experimentsCognitive functionMediation analysisDrinking outcomesMemoryLess drinkingAlcohol useDrinking behaviorIndirect effectsLaboratory sessionsDrinking taskVarenicline doseChild Maltreatment and Physical Victimization: Does Heavy Drinking Mediate the Relationship?
Smith KZ, Smith PH, Oberleitner LM, Grekin ER, McKee SA. Child Maltreatment and Physical Victimization: Does Heavy Drinking Mediate the Relationship? Child Maltreatment 2018, 23: 234-243. PMID: 29347837, DOI: 10.1177/1077559517751669.Peer-Reviewed Original ResearchPharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems.
Verplaetse TL, McKee SA, Petrakis IL. Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems. Alcohol Research 2018, 39: 193-205. PMID: 31198658, PMCID: PMC6561397.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismBrainComorbidityHumansNeurotransmitter AgentsStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderCo-occurring alcohol use disorderAlcohol use disorderComorbid alcohol use disorderStress disorderNeurobiological systemsMaintenance of AUDUse disordersPTSD symptom severityAlcohol-motivated behaviorsAlcohol use outcomesPharmacologic treatment strategiesBrain systemsTreatment of individualsCurrent medicationsComorbid populationGlutamatergic systemPotential pharmacotherapyPharmacologic interventionsUse outcomesTreatment outcomesTreatment strategiesSingular diagnosisDual diagnosisTreatment interventions
2017
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal Of Psychopharmacology 2017, 31: 906-914. PMID: 28351203, PMCID: PMC5823265, DOI: 10.1177/0269881117699618.Peer-Reviewed Original ResearchConceptsDepressive symptomsAlcohol cravingAlcohol useEffects of vareniclineRole of nAChRsHuman laboratory studiesDSM-IV criteriaSymptoms of depressionAlcohol use disorderLaboratory testing sessionsMore depressive symptomsMedication pretreatmentPlasma levelsPriming doseVareniclineUse disordersTreatment moderatorsAlcohol consumptionDepression symptomsHeavy drinkersAlcohol usersDrinking taskSymptomsLess drinkingDrinkers