2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionExamining the relationship of concurrent obesity and tobacco use disorder on the development of substance use disorders and psychiatric conditions: Findings from the NESARC-III
Fields L, Roberts W, Schwing I, McCoy M, Verplaetse T, Peltier M, Carretta R, Zakiniaeiz Y, Rosenheck R, McKee S. Examining the relationship of concurrent obesity and tobacco use disorder on the development of substance use disorders and psychiatric conditions: Findings from the NESARC-III. Drug And Alcohol Dependence Reports 2023, 7: 100162. PMID: 37159814, PMCID: PMC10163607, DOI: 10.1016/j.dadr.2023.100162.Peer-Reviewed Original ResearchTobacco use disorderSubstance use disordersBody mass indexUse disordersPsychiatric conditionsRisk of SUDAdditional substance use disordersSingle health conditionsRelated Conditions Wave IIIWorse health outcomesNational Epidemiological SurveyPsychiatric disorder diagnosisHarmful substance useDSM-5 criteriaConcurrent obesityComorbid obesityMass indexSUD diagnosisRisk factorsObesityComorbid diagnosesEpidemiological surveyHealth outcomesNESARC-IIIDisorder diagnosis
2014
Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity
Udo T, McKee SA, Grilo CM. Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity. General Hospital Psychiatry 2014, 37: 120-125. PMID: 25537344, PMCID: PMC4361288, DOI: 10.1016/j.genhosppsych.2014.11.011.Peer-Reviewed Original ResearchConceptsBeck Depression InventoryObese patientsMood disordersClinical utilityDepression InventoryDisorder psychopathologyHigh negative predictive valueMajor depressive disorderNegative predictive valueTreatment-seeking obese patientsExcellent internal consistencyDepressive disorderSelf-report questionnairesDepression symptomsPredictive valuePatientsThree-factor structureScreening instrumentDisordersObesityVariable associationsInternal consistency
2013
The factor structure of the metabolic syndrome in obese individuals with binge eating disorder
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. The factor structure of the metabolic syndrome in obese individuals with binge eating disorder. Journal Of Psychosomatic Research 2013, 76: 152-157. PMID: 24439692, PMCID: PMC3953028, DOI: 10.1016/j.jpsychores.2013.10.007.Peer-Reviewed Original ResearchConceptsObese individualsMetabolic syndromeMetabolic measuresHigh-risk populationType II diabetesBlood pressurePatient groupExcess weightSubgroup analysisCardiovascular diseaseRisk populationsGlucose regulationTreatment studiesVARCLUS procedurePopulation studiesFactor structureSyndromeBingeDisordersMetSDiverse populationsFour-factor structureIndividualsStatistical Analysis SystemObesity
2012
Does co-morbid depression alter the inverse relationship between obesity and substance use disorders?
Gearhardt AN, Harrison EL, McKee SA. Does co-morbid depression alter the inverse relationship between obesity and substance use disorders? Drug And Alcohol Dependence 2012, 124: 185-188. PMID: 22285319, PMCID: PMC3359394, DOI: 10.1016/j.drugalcdep.2012.01.002.Peer-Reviewed Original ResearchConceptsSubstance use disordersCo-morbid depressionDrug use disordersUse disordersRisk factorsMajor depressionOverweight/obesity statusCommon risk factorsInverse relationshipNormal weightObesity statusExcess food consumptionPsychiatric disordersDepression disorderObesityDrug useReward circuitryU.S. adultsSubstance useDisordersDepressionAdultsFood consumptionRepresentative sampleCurrent study