2024
Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationship
2023
Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments
Fox H, Milivojevic V, Sinha R. Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments. Handbook Of Experimental Pharmacology 2023, 282: 127-161. PMID: 37592081, DOI: 10.1007/164_2023_687.Peer-Reviewed Original ResearchConceptsSubstance-using womenExogenous progesteroneBetter tailor treatmentsStress-induced cravingFace of stressSex-specific targetsGender-related differencesAdrenergic medicationsStress-related adaptationClinical trialsSpecific treatmentMedication developmentAlcohol consumptionCompulsive drugBiobehavioral mechanismsDrinking historyMedical problemsInnovative medicationsMedicationsNovel targetWomenGuanfacineProgesteroneTreatmentEfficacyMifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler C, Magill M, Cannella N, Brown J, Aoun E, Cioe P, Sinha R, Swift R, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study. Addiction Biology 2023, 28: e13288. PMID: 37369125, PMCID: PMC10313137, DOI: 10.1111/adb.13288.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHuman laboratory studiesAdverse eventsAlcohol pharmacokineticsAlcohol cravingSubjective effectsSafety of mifepristonePlacebo-controlled trialStress-induced alcoholLack of effectCue-reactivity procedureBlood pressurePhase 1/2Alcohol drinkingGeneralized Estimating EquationsYohimbine administrationHemodynamic parametersPharmacological interventionsSaliva outputDay administrationUse disordersMifepristoneNon-treatment seekersAlcohol consumptionPlacebo condition
2017
2320
Brewton H, Stangl B, Kwako L, Sinha R, Ramchandani V. 2320. Journal Of Clinical And Translational Science 2017, 1: 35-35. PMCID: PMC6799609, DOI: 10.1017/cts.2017.129.Peer-Reviewed Original ResearchDrug Effects QuestionnaireBinge drinkersAlcohol Urge QuestionnaireACTH levelsACTH peakNonbinge drinkersAlcohol cuesHPA axis measuresSerial blood samplesHPA axis reactivityAdrenal axis markersAlcohol-dependent individualsACTH ratioBinge groupIntravenous alcoholAlcohol relapseBlood samplesAlcohol consumptionEffects QuestionnaireAlcohol cravingACTH changesDistress ScaleDrinkersSignificant predictorsNeutral scripts
2011
Modeling Relapse Situations in the Human Laboratory
Sinha R. Modeling Relapse Situations in the Human Laboratory. Current Topics In Behavioral Neurosciences 2011, 13: 379-402. DOI: 10.1007/978-3-642-28720-6_150.Peer-Reviewed Original ResearchHuman laboratoryAlcohol relapse riskStress-related dysregulationBrain imaging studiesNovel treatment interventionsHuman laboratory proceduresAlcohol-dependent individualsChronic relapsing illnessAlcohol seekingRelapse situationsStress processRelapse outcomesRelapse riskAlcohol relapseAlcohol useTreatment interventionsReciprocal relationshipEmpirical findingsAlcoholism riskCentral stressImaging studiesSuch dysregulationAlcohol consumptionSeekingAlcoholism
1989
Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates
Sinha R, Parsons O, Glenn S. Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates. Alcohol 1989, 6: 77-85. PMID: 2719819, DOI: 10.1016/0741-8329(89)90077-3.Peer-Reviewed Original ResearchConceptsDrinking variablesNeuropsychological performance scoresFamily history-negative (FH-) alcoholicsNeuropsychological test performanceAlcohol intake measuresCognitive functioningNeuropsychological measuresAlcohol consumption variablesAffective measuresFemale alcoholicsNeuropsychological performanceTest performanceDepression Inventory scoresAffective symptomatologyAnxiety scoresBeck Depression Inventory scoresImpairment IndexFamilial alcoholismInventory scoresPerformance scoresIntake measuresMeasuresSignificant relationshipGender correlatesAlcohol consumption