2024
Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
Parida S, MacLean R, Gueorguieva R, Sofuoglu M. Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans. Psychopharmacology 2024, 241: 1915-1922. PMID: 38970644, DOI: 10.1007/s00213-024-06609-6.Peer-Reviewed Original ResearchDiscriminative stimulus effectsAddiction thresholdNicotine doseDiscriminative stimulus effects of nicotineStimulus effects of nicotineNicotine deliveryEffects of nicotineOvernight abstinenceStimulus effectsNicotine infusionSubjective effectsTest sessionsNicotineMethodsEleven participantsInfusion procedureLow dosesParticipantsThreshold doseConclusionsTheseAbstinenceDoseHeart rateInfusionSmokingObjectivesTo
2022
Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects
DeVito E, Sofuoglu M. Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects. Current Behavioral Neuroscience Reports 2022, 9: 113-123. PMID: 36644316, PMCID: PMC9838826, DOI: 10.1007/s40473-022-00251-2.Peer-Reviewed Original ResearchSmoking behaviorPreliminary dataHuman laboratory studiesCigarette smoking behaviorShort-term abstinenceNicotine administrationSmoking cessationTreatment optionsWithdrawal symptomsCessation outcomesPharmacogenetic effectsOvernight abstinenceMet carriersSmoking urgesActivity genotypeReviewThis articleSymptomsCOMT geneSex differencesAbstinenceFunctional variantsSmokingCigarettesAdministrationIndividualsProgesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence
Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Epperson CN. Progesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence. Nicotine & Tobacco Research 2022, 24: 1898-1905. PMID: 35713950, PMCID: PMC9653080, DOI: 10.1093/ntr/ntac146.Peer-Reviewed Original ResearchConceptsBrief abstinenceNegative affectNicotine withdrawalNicotine use disorderUse disordersFemale smokersNeural measuresFinal drug administrationSmoking cuesSmoking-related outcomesNeural responsesEffect of progesteroneSmoking urgesMood statesSex-dependent effectsSmoking outcomesNicotine effectsDrug AdministrationAbstinence periodSubjective effectsNicotine dependenceAbstinenceMain effectSignificant sexPlacebo-controlled crossover studyP687. Sex-Dependent Effects of Progesterone on Nicotine Withdrawal and Neural Response to Smoking Cues During Brief Abstinence
Novick A, Duffy K, Johnson R, Sammel M, Cao W, Strasser A, Sofuoglu M, Kuzma A, Loughead J, Epperson C. P687. Sex-Dependent Effects of Progesterone on Nicotine Withdrawal and Neural Response to Smoking Cues During Brief Abstinence. Biological Psychiatry 2022, 91: s368-s369. DOI: 10.1016/j.biopsych.2022.02.924.Peer-Reviewed Original Research