2023
Adherence to Antiretrovirals and HIV Viral Suppression Under COVID-19 Pandemic Interruption – Findings from a Randomized Clinical Trial Using Ingestible Sensors to Monitor Adherence
Wang Y, Daar E, Huang Y, Xiong D, Shen J, Zhou L, Siqueiros L, Guerrero M, Rosen M, Liu H. Adherence to Antiretrovirals and HIV Viral Suppression Under COVID-19 Pandemic Interruption – Findings from a Randomized Clinical Trial Using Ingestible Sensors to Monitor Adherence. AIDS And Behavior 2023, 27: 4041-4051. PMID: 37401993, PMCID: PMC10598162, DOI: 10.1007/s10461-023-04118-9.Peer-Reviewed Original ResearchConceptsLog viral loadViral loadClinical trialsHIV RNA viral loadUsual care groupHIV viral suppressionRNA viral loadRandomized clinical trialsSelf-reported adherenceLongitudinal mixed effects modelsViral suppressionClinical outcomesCare groupWeek 28Week 16Intervention groupAntiretroviralsIntervention effectsVulnerable populationsAdherenceMixed effects modelsRandom interceptRetention rateCOVID-19 pandemicIngestible sensor
2022
Ingestible sensor system for measuring, monitoring and enhancing adherence to antiretroviral therapy: An open-label, usual care-controlled, randomised trial
Liu H, Wang Y, Huang Y, Xiong D, Shen J, Siqueiros L, Bala V, Savage G, Guerrero M, Corado K, Rosen M, Fletcher C, Daar E. Ingestible sensor system for measuring, monitoring and enhancing adherence to antiretroviral therapy: An open-label, usual care-controlled, randomised trial. EBioMedicine 2022, 86: 104330. PMID: 36372731, PMCID: PMC9782816, DOI: 10.1016/j.ebiom.2022.104330.Peer-Reviewed Original ResearchConceptsHIV RNA viral loadRNA viral loadViral loadARV concentrationsUC groupIngestible sensorUsual care groupIngestible Sensor SystemOverall satisfaction rateInstitute of HealthGroup-based trajectory modelsAdvancing Translational SciencesAntiretroviral therapyHIV clinicCare groupText remindersIS groupImproved adherenceMeasure scoresSatisfaction rateStudy participantsAntiretroviralsMental healthAdherenceNational Institute