2001
Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI
Hyder F, Kida I, Behar K, Kennan R, Maciejewski P, Rothman D. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR In Biomedicine 2001, 14: 413-431. PMID: 11746934, DOI: 10.1002/nbm.733.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebrovascular CirculationEnergy MetabolismMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleOxygenOxygen ConsumptionRatsRats, Sprague-DawleyConceptsMagnetic resonance imagingNeuronal activityBOLD functional MRIFunctional MRICerebral cortexPharmacological treatmentGlutamate release inhibitorNeuronal glucose oxidationRat cerebral cortexRelease of glutamateRat forepaw stimulation modelFMRI signalsFunctional magnetic resonance imagingQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesEnergy metabolismBOLD fMRI signalMulti-modal magnetic resonance imagingGlutamatergic neuronsRelease inhibitorChannel blockersRat brainOxygen deliveryNeurochemical basis
2000
Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study
Hyder F, Kennan R, Kida I, Mason G, Behar K, Rothman D. Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 485-498. PMID: 10724113, DOI: 10.1097/00004647-200003000-00007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCapillary bedOxygen deliveryML xCerebral oxygen deliveryNicotine hydrogen tartrateRespective control conditionsValues of CBFMorphine anesthesiaSensorimotor cortexForepaw stimulationSodium pentobarbitalRat brainBlood flowCMRO2Mature ratsCortical activityResonance imagingBasal conditionsPercentage changeRatsAdministrationCBF
1994
Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation
Hyder F, Behar K, Martin M, Blamire A, Shulman R. Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation. Cerebrovascular And Brain Metabolism Reviews 1994, 14: 649-655. PMID: 8014212, DOI: 10.1038/jcbfm.1994.81.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingCerebral AngiographyCerebrovascular CirculationElectric StimulationFootMagnetic Resonance ImagingMaleRatsRats, Sprague-DawleyConceptsSomatosensory areaChloralose-anesthetized ratsDynamic magnetic resonance imagingMagnetic resonance imagingForelimb motorForepaw stimulationRat brainBrain mapping methodsElectrical stimulationMR signal intensityParietal cortexResonance imagingBrain tissueCoronal planeFractional signal changeStimulationSignal changesOxygenation stateSignal intensityRatsAnteriorCortexBloodBrain
1993
NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia
Hossmann K, Behar K, Rothman D. NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia. Acta Neurochirurgica Supplement 1993, 57: 21-29. PMID: 8421952, DOI: 10.1007/978-3-7091-9266-5_3.Peer-Reviewed Original ResearchConceptsHour complete ischemiaResidual blood flowBlood flowComplete ischemiaBrain injuryComplete recoveryBrain energy stateIrreversible brain injuryDuration of ischemiaAppropriate therapeutic measuresRise of lactatePost-ischemic injuryN-acetyl aspartateNon-invasive assessmentBrain glucose contentDepth of anesthesiaLower metabolite levelsBlood reperfusionIschemia timeReflow phenomenonBrain metabolismContinuous non-invasive assessmentProlonged ischemiaTherapeutic measuresIschemia