2006
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo
Patel AB, de Graaf RA, Martin DL, Battaglioli G, Behar KL. Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo. Journal Of Neurochemistry 2006, 97: 385-396. PMID: 16539672, DOI: 10.1111/j.1471-4159.2006.03741.x.Peer-Reviewed Original ResearchMeSH Keywords4-Aminobutyrate TransaminaseAnimalsAnticonvulsantsBicucullineBlotting, WesternDose-Response Relationship, DrugGABA AntagonistsGamma-Aminobutyric AcidGlutamate DecarboxylaseIsoenzymesMagnetic Resonance SpectroscopyMaleProtein IsoformsRatsRats, Sprague-DawleySeizuresTime FactorsVigabatrin
1996
Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy
Petroff O, Behar K, Mattson R, Rothman D. Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy. Journal Of Neurochemistry 1996, 67: 2399-2404. PMID: 8931472, DOI: 10.1046/j.1471-4159.1996.67062399.x.Peer-Reviewed Original ResearchConceptsBrain GABA contentImproved seizure controlBrain GABA levelsSeizure controlVigabatrin treatmentGABA levelsDaily doseAntiepileptic drugsOccipital lobeBrain gamma-aminobutyric acid (GABA) concentrationsGABA concentrationHuman brain GABA levelsGABA contentGamma-aminobutyric acid concentrationΓ-aminobutyric acid (GABA) levelsComplex partial seizuresNovel antiepileptic drugBrain GABA concentrationsSeizure frequencyPartial seizuresVigabatrin therapySustained elevationHuman occipital lobeGABA synthesisAcid levels
1983
Cerebral metabolic studies in vivo by 31P NMR.
Prichard J, Alger J, Behar K, Petroff O, Shulman R. Cerebral metabolic studies in vivo by 31P NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2748-2751. PMID: 6573678, PMCID: PMC393905, DOI: 10.1073/pnas.80.9.2748.Peer-Reviewed Original ResearchConceptsStatus epilepticusCerebral metabolic studiesNitrous oxide analgesiaHypoxic hypoxiaMetabolic disturbancesCardiovascular functionInsulin shockEpilepticusHypoglycemiaLiving rabbitsCreatine kinaseMetabolic stressPhosphocreatine storesHypoxiaMetabolic studiesADP levelsATP levelsReversible decreaseSimilar changesPhosphocreatine poolBrainPhysiological variablesSurface coilAnalgesia