Featured Publications
Dynamic structural equation modeling of the relationship between alcohol habit and drinking variability
DeMartini KS, Gueorguieva R, Taylor JR, Krishnan-Sarin S, Pearlson G, Krystal JH, O'Malley SS. Dynamic structural equation modeling of the relationship between alcohol habit and drinking variability. Drug And Alcohol Dependence 2021, 233: 109202. PMID: 35151022, PMCID: PMC10046111, DOI: 10.1016/j.drugalcdep.2021.109202.Peer-Reviewed Original ResearchMapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers
DeMartini KS, Gueorguieva R, Pearlson G, Krishnan‐Sarin S, Anticevic A, Ji LJ, Krystal JH, O’Malley S. Mapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers. Alcohol Clinical And Experimental Research 2021, 45: 841-853. PMID: 33605439, DOI: 10.1111/acer.14580.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisIncentive salienceNeurofunctional domainsAlcohol use disorderExecutive functionLatent factorsPhysical neglectSelf-report measuresChildhood emotional abuseUse disordersChildhood physical neglectEarly life stressSignificant predictorsMultiple significant predictorsMultiple causes modelCurrent AUDNegative emotionalityAddiction developmentEmotional abuseChildhood neglectFactor structureDrinking frequencySalienceCause modelFactor analysisThe Impact of Integrated Behavioral Healthcare on Glycemic Control
MacGregor KL, DeMartini KS, Barry-Menkhaus SA, Derr AG, Thompson MJ. The Impact of Integrated Behavioral Healthcare on Glycemic Control. Journal Of Clinical Psychology In Medical Settings 2021, 29: 636-644. PMID: 34436717, DOI: 10.1007/s10880-021-09817-w.Peer-Reviewed Original ResearchConceptsGlycemic controlMetabolic statusBehavioral health encountersPost-intervention slopeStandard of carePatient's metabolic statusBehavioral healthcareDiabetes outcomesHealth encountersPsychosocial factorsBehavioral healthSignificant linear decreaseVisitsAdultsMixed effectsSlope trajectoriesHbA1cHealthcareClinicCareA Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint)
Fucito LM, Ash GI, DeMartini KS, Pittman B, Barnett NP, Li CR, Redeker NS, O'Malley SS. A Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint). JMIR Research Protocols 2021, 10: e26557. PMID: 33635276, PMCID: PMC7954653, DOI: 10.2196/26557.Peer-Reviewed Original ResearchSleep hygiene adviceINTERNATIONAL REGISTERED REPORT IDENTIFIERHeavy-drinking young adultsHygiene adviceSleep interventionsYoung adultsAlcohol diaryAlcohol use disorder riskRisky alcohol consumptionAlcohol use disorderLow-cost interventionAlcohol behavior changeControlled TrialsWeb-based sessionsBrief adviceHealth coachesRisk factorsPoor sleepRecent heavy drinkingSleep characteristicsUse disordersAlcohol consumptionAlcohol-related consequencesPriority populationsSecondary aimText Messaging to Reduce Alcohol Relapse in Prelisting Liver Transplant Candidates: A Pilot Feasibility Study
DeMartini KS, Schilsky ML, Palmer A, Fehon DC, Zimbrean P, O'Malley SS, Lee HB, Toll BA. Text Messaging to Reduce Alcohol Relapse in Prelisting Liver Transplant Candidates: A Pilot Feasibility Study. Alcohol Clinical And Experimental Research 2018, 42: 761-769. PMID: 29498753, PMCID: PMC6438371, DOI: 10.1111/acer.13603.Peer-Reviewed Original ResearchConceptsAlcoholic liver diseaseLiver transplant candidatesLiver transplant patientsStandard careEfficacy outcomesTransplant patientsTransplant candidatesFeasibility outcomesTM participantsAlcohol interventionsClinical efficacy outcomesLiver transplantation programPreliminary efficacy outcomesPrimary feasibility outcomePilot feasibility trialPilot feasibility studyRelapse prevention interventionsBetter treatment outcomesLiver diseaseFeasibility trialUnited NetworkTransplantation programIntervention satisfactionTreatment outcomesAlcohol relapseSensitivity, specificity, and tolerability of the BACTrack Skyn compared to other alcohol monitoring approaches among young adults in a field‐based setting
Ash GI, Gueorguieva R, Barnett NP, Wang W, Robledo DS, DeMartini KS, Pittman B, Redeker NS, O’Malley S, Fucito LM. Sensitivity, specificity, and tolerability of the BACTrack Skyn compared to other alcohol monitoring approaches among young adults in a field‐based setting. Alcohol Clinical And Experimental Research 2022, 46: 783-796. PMID: 35567595, PMCID: PMC9179100, DOI: 10.1111/acer.14804.Peer-Reviewed Original ResearchDrinking Goals and Attainment in a Naltrexone Trial of Young Adult Heavy Drinkers
DeMartini KS, Foster DW, Corbin WR, Fucito LM, Romano D, Leeman RF, Kranzler HR, O’Malley S. Drinking Goals and Attainment in a Naltrexone Trial of Young Adult Heavy Drinkers. Journal Of Consulting And Clinical Psychology 2018, 86: 765-774. PMID: 30138015, PMCID: PMC6435339, DOI: 10.1037/ccp0000323.Peer-Reviewed Original ResearchConceptsTreatment outcomesAdult heavy drinkersYoung adult heavy drinkersHeavy drinkersDrinking goalEnd of treatmentPeak drinkingBetter treatment outcomesAlcohol use disorderImpact treatment outcomesTypical drinkingYoung adult drinkersEfficacy trialsUse disordersBrief counselingGoal settingIntervention effectsGoal-setting exercisesAdult drinkersDrinkersOutcomesDrinkingTreatmentImportant targetMidtreatment
2024
Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement
Lee B, Witkiewitz K, Mellinger J, Anania F, Bataller R, Cotter T, Curtis B, Dasarathy S, DeMartini K, Diamond I, Diazgranados N, DiMartini A, Falk D, Fernandez A, German M, Kamath P, Kidwell K, Leggio L, Litten R, Louvet A, Lucey M, McCaul M, Sanyal A, Singal A, Sussman N, Terrault N, Thursz M, Verna E, Radaeva S, Nagy L, Mitchell M. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nature Reviews Gastroenterology & Hepatology 2024, 21: 626-645. PMID: 38849555, DOI: 10.1038/s41575-024-00936-x.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseAlcohol use disorderLiver diseaseClinical trialsRisk of decompensation of liver diseaseAlcohol useUse disorderTreatment of alcohol use disordersExpert panel consensus statementDecompensation of liver diseaseAddiction medicine specialistsProgression of liver diseaseLiver-related outcomesNational Institute of Alcohol AbuseDesigning clinical trialsEffects of alcohol useConsensus of expert opinionTask ForceConsensus statementMedicine specialistsAlcohol abuseHeavy drinkingDiseaseClinical trialistsPatients
2022
Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation
Waddell JT, Corbin WR, MacKinnon DP, Leeman RF, DeMartini KS, Fucito LM, Kranzler HR, O’Malley S. Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation. Alcohol Clinical And Experimental Research 2022, 46: 477-491. PMID: 35076087, PMCID: PMC9679805, DOI: 10.1111/acer.14780.Peer-Reviewed Original ResearchConceptsMedication dosageYoung adultsLight drinkingSubjective responsesSubjective effectsHeavy drinkingPlacebo-controlled studyEffect sizePerson effectsEffective treatmentNaltrexoneDrinking daysNaltrexone efficacySmall effect sizesDrinking levelsCravingDrinkingAdultsLaboratory-based studiesPillsMomentary assessmentEfficacyTreatment conditionsDrinking environmentsDaily diary data
2021
Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial
Patel KT, Stevens MC, Dunlap A, Gallagher A, O’Malley S, DeMartini K, Potenza MN, Krystal JH, Pearlson GD. Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial. Neuropsychopharmacology 2021, 47: 840-846. PMID: 34475522, PMCID: PMC8882177, DOI: 10.1038/s41386-021-01157-5.Peer-Reviewed Original ResearchConceptsProtein tyrosine kinasesSrc regulationSrc familyProtein kinaseTyrosine kinaseFyn kinaseSrc inhibitorSrc/FynDependent pathwayKinaseNMDAR upregulationNMDAR functionNMDA receptorsRegulationSaracatinibGluN2B subunitGlutamate receptorsFynInhibitorsReceptorsSubunitsN-methyl-D-aspartate (NMDA) glutamate receptorsPrevious evidenceSaracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants
Thompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.Peer-Reviewed Original ResearchNMDA receptorsSrc/FynAlcohol consumptionEffect of saracatinibVehicle 2 hChronic alcohol useDays of treatmentDSM-IV criteriaMore effective treatmentsNumber of drinksGlutamatergic systemAdditional drinkAlcohol drinkingAdditional dosesEthanol exposureEffective treatmentNR2B subunitAlcohol abuseHuman studiesPriming drinkAlcohol cravingSaracatinibDrinking paradigmNovel pharmacotherapeuticsHuman participantsIndividual Differences in the Associations Between Risk Factors for Alcohol Use Disorder and Alcohol Use-Related Outcomes
Haeny AM, Gueorguieva R, Jackson A, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O’Malley S. Individual Differences in the Associations Between Risk Factors for Alcohol Use Disorder and Alcohol Use-Related Outcomes. Psychology Of Addictive Behaviors 2021, 35: 501-513. PMID: 34110841, PMCID: PMC9211405, DOI: 10.1037/adb0000733.Peer-Reviewed Original Research73936 Developing a Patient-Rated Outcome Measure of Alcohol and Drug Craving: A Systematic Review
Haeny A, Morean M, DeMartini K, Funaro M, O’Malley S. 73936 Developing a Patient-Rated Outcome Measure of Alcohol and Drug Craving: A Systematic Review. Journal Of Clinical And Translational Science 2021, 5: 39-39. PMCID: PMC8827664, DOI: 10.1017/cts.2021.505.Peer-Reviewed Original ResearchPatient-rated outcome measuresOutcome measuresSystematic reviewClinical trialsDrug useStimulant usePatient rated outcome measuresSubstance use disordersEffective treatmentPRISMA guidelinesUse disordersElectronic databasesDrug cravingPotential targetOpioidsCravingFDANicotineTrialsDisordersResults/CannabisReviewFindingsMedicationsReward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original Research
2020
Using Web-Based Social Media to Recruit Heavy-Drinking Young Adults for Sleep Intervention: Prospective Observational Study
Ash GI, Robledo DS, Ishii M, Pittman B, DeMartini KS, O'Malley SS, Redeker NS, Fucito LM. Using Web-Based Social Media to Recruit Heavy-Drinking Young Adults for Sleep Intervention: Prospective Observational Study. Journal Of Medical Internet Research 2020, 22: e17449. PMID: 32780027, PMCID: PMC7448185, DOI: 10.2196/17449.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSleep interventionsSleep concernsYoung adultsAlcohol useWeb-based surveyBrief web-based surveyProspective observational studyHeavy-drinking young adultsYears of ageHigh response rateAlcohol prevention strategiesHeavy alcohol useAlcohol prevention programsHeavy drinking young adultsScreening eligibilityRisk factorsStudy enrolleesObservational studySleep programSleep problemsAlcohol screenerUse disordersPrevention strategiesResponse rateExamining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance?
DeMartini KS, Pittman B, Krystal JH, O’Malley S, Krishnan‐Sarin S. Examining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance? Alcohol Clinical And Experimental Research 2020, 44: 1151-1157. PMID: 32352581, PMCID: PMC10158572, DOI: 10.1111/acer.14329.Peer-Reviewed Original ResearchConceptsSelf-reported drinkingAlcohol cravingDrinking daysAlcohol consumptionDrinking paradigmHeavy drinking daysAlcohol use disorderSummary drinking measuresMaximum drinksPharmacotherapy studiesAdult heavy drinkersMedication administrationAverage drinksUse disordersHeavy drinkersAlcohol assessmentSignificant associationTotal drinksDrinking sessionDrinking indicesAdditional outcomesBehavioral interventionsLimited evidenceRisk classificationCravingDrinking and responses to antidrinking messages among young adults: An fMRI study
Garrison KA, DeMartini KS, Corlett PR, Worhunsky PD, Krystal JH, O'Malley SS. Drinking and responses to antidrinking messages among young adults: An fMRI study. Addiction Biology 2020, 26: e12882. PMID: 32068323, PMCID: PMC7431375, DOI: 10.1111/adb.12882.Peer-Reviewed Original ResearchConceptsDrinking cuesNeural responsesYoung adultsFunctional magnetic resonanceSelf-reported drinkingPast monthNeutral cuesDrug cuesSmoking cuesHabitual responsesReward processingFMRI studyDrinking quantityCuesDependent individualsSubstance useAlcohol useBinge drinkingNegative consequencesGreater baselinePublic health campaignsExcessive drinkingHeavy drinkingHealth campaignsDrinking
2019
The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences
Haeny AM, Gueorguieva R, Morean ME, Krishnan‐Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS. The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences. Alcohol Clinical And Experimental Research 2019, 44: 159-167. PMID: 31693193, PMCID: PMC6981005, DOI: 10.1111/acer.14230.Peer-Reviewed Original ResearchConceptsFacets of impulsivityBarratt Impulsiveness ScaleAlcohol-related problemsAlcohol use disorderProblem drinkingAssociation of impulsivityImpulsivity-related traitsAlcohol-related consequencesUse disordersFHP individualsAlcohol outcomesImpulsiveness ScaleImpulsivityProblematic drinkingFHN individualsDrinking quantityAlcohol quantityTranslational neuroscienceAlcohol misuseAlcohol useTransdisciplinary Tobacco Use Research CenterMain effectAnalysis of covariancePhenotypic riskStrong positive association
2018
Active Coping and Perceived Social Support Mediate the Relationship Between Physical Health and Resilience in Liver Transplant Candidates
Swanson A, Geller J, DeMartini K, Fernandez A, Fehon D. Active Coping and Perceived Social Support Mediate the Relationship Between Physical Health and Resilience in Liver Transplant Candidates. Journal Of Clinical Psychology In Medical Settings 2018, 25: 485-496. PMID: 29546621, DOI: 10.1007/s10880-018-9559-6.Peer-Reviewed Original ResearchConceptsLiver transplant candidatesTransplant candidatesPhysical functioningPsychological resiliencePhysical healthActive copingEnd-stage liver diseaseSocial supportWait-listed candidatesWait-list periodSocial support mediatesActive coping skillsLiver diseaseSignificant morbidityTransplant centersCare providersMaladaptive copingPsychological stressSocial support networksCoping skillsCopingHealthFunctioningSupport networksResilienceThe Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use
Morean ME, DeMartini KS, Foster D, Patock-Peckham J, Garrison KA, Corlett PR, Krystal JH, Krishan-Sarin S, O'Malley SS. The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use. Drug And Alcohol Dependence 2018, 186: 207-214. PMID: 29609132, PMCID: PMC5912163, DOI: 10.1016/j.drugalcdep.2018.01.014.Peer-Reviewed Original Research