2020
Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease
Weintraub D, Caspell‐Garcia C, Simuni T, Cho HR, Coffey CS, Aarsland D, Alcalay RN, Barrett MJ, Chahine LM, Eberling J, Espay AJ, Hamilton J, Hawkins KA, Leverenz J, Litvan I, Richard I, Rosenthal LS, Siderowf A, York M, Initiative P. Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease. Annals Of Clinical And Translational Neurology 2020, 7: 449-461. PMID: 32285645, PMCID: PMC7187707, DOI: 10.1002/acn3.51022.Peer-Reviewed Original ResearchConceptsParkinson's disease participantsNeuropsychiatric symptomsParkinson's diseaseHealthy controlsCognitive impairmentMedication useYear 5Anticholinergic medication useCross-sectional prevalenceParkinson's disease patientsHypnotic useDisease patientsNeuropsychiatric featuresDisease onsetAnnual visitsSymptomsDisorder subtypesAbsolute prevalenceDiseaseTime pointsPrevalenceBaselineImpairmentParticipantsOnset
2018
Cognition among individuals along a spectrum of increased risk for Parkinson’s disease
Chahine LM, Urbe L, Caspell-Garcia C, Aarsland D, Alcalay R, Barone P, Burn D, Espay AJ, Hamilton JL, Hawkins KA, Lasch S, Leverenz JB, Litvan I, Richard I, Siderowf A, Coffey CS, Simuni T, Weintraub D, Initiative T. Cognition among individuals along a spectrum of increased risk for Parkinson’s disease. PLOS ONE 2018, 13: e0201964. PMID: 30125297, PMCID: PMC6101368, DOI: 10.1371/journal.pone.0201964.Peer-Reviewed Original ResearchConceptsParkinson's diseaseIdiopathic REM sleep behavior disorderParkinson's Progression Markers Initiative (PPMI) studyDe novo Parkinson's diseaseREM sleep behavior disorderDopamine transporterNon-motor symptomsNovo Parkinson's diseaseSleep behavior disorderNon-motor featuresSymbol Digit Modalities TestBaseline neuropsychological performanceMontreal Cognitive AssessmentFuture neurodegenerationLewy bodiesInclusion criteriaSpectrum of riskMutation carriersInitiative studyCohortBehavior disorderCognitive functionCognitive test scoresModalities TestNeuropsychological performanceGuanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDose
2017
Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Initiative T. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. PLOS ONE 2017, 12: e0175674. PMID: 28520803, PMCID: PMC5435130, DOI: 10.1371/journal.pone.0175674.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitive DysfunctionDiffusion Tensor ImagingDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideTau ProteinsTomography, Emission-Computed, Single-PhotonConceptsParkinson's diseaseCognitive impairmentDe novo Parkinson's diseaseDopamine transporter single-photon emissionLongitudinal mixed-effects modelsNovo Parkinson's diseaseYears of diseaseIdiopathic Parkinson's diseaseMovement Disorders CenterSingle nucleotide polymorphismsStructural magnetic resonance imagingClinical trial designLongitudinal structural MRIMagnetic resonance imagingSingle photon emissionDevelopment of treatmentsDiffusion tensor imagingBiomarker predictorsPlaque pathologyAmyloid pathologyDopamine deficiencyDopaminergic deficitUnivariate analysisBiomarker changesDisorders Center
2015
Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings
Chahine M, Weintraub D, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, Investigators T. Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. Movement Disorders 2015, 31: 86-94. PMID: 26293177, PMCID: PMC4827252, DOI: 10.1002/mds.26373.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnxietyAttentionCocaineCognition DisordersCohort StudiesExecutive FunctionFemaleHumansLanguageMaleMemoryMiddle AgedNeurogenic BowelNeuropsychological TestsOlfaction DisordersParkinson DiseaseProtein BindingRadiopharmaceuticalsSelf ReportSeverity of Illness IndexStatistics, NonparametricSurveys and QuestionnairesTomography, Emission-Computed, Single-PhotonVisual PerceptionConceptsExecutive function/Global cognitionRelative impairmentSpecific cognitive domainsSpeed/attentionGlobal cognitive abilityNeuropsychological test batteryLower global cognitionFunction/Cognitive abilitiesCognitive domainsCognitive profileVisuospatial abilitiesLanguage domainsCognitive testingTest batteryCognitionNormative scoresMemoryLower mean scoresHealthy adultsNon-motor featuresIndividualsStudy findingsNon-motor symptomsRBANS Norms based on the Relationship of Age, Gender, Education, and WRAT-3 Reading to Performance within an Older African American Sample
Andreotti C, Hawkins KA. RBANS Norms based on the Relationship of Age, Gender, Education, and WRAT-3 Reading to Performance within an Older African American Sample. The Clinical Neuropsychologist 2015, 29: 442-465. PMID: 26035646, DOI: 10.1080/13854046.2015.1039589.Peer-Reviewed Original ResearchCognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease
Weintraub D, Simuni T, Caspell‐Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine M, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Initiative T. Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Movement Disorders 2015, 30: 919-927. PMID: 25737166, PMCID: PMC4855523, DOI: 10.1002/mds.26170.Peer-Reviewed Original ResearchConceptsParkinson's Progression Markers InitiativeNeuropsychiatric symptomsPD patientsHealthy controlsProgression Markers InitiativeParkinson's diseaseCognitive impairmentUntreated PD patientsDopamine replacement therapySignificant depressive symptomsGroup differencesSymptoms of depressionQuality of lifeMild cognitive impairmentUntreated patientsDisease courseReplacement therapyICD symptomsControl disordersDepressive symptomsGeneral populationPatientsMeeting criteriaMulti-site studyBiological predictors
2011
Age and Gender but Not Common Chronic Illnesses Predict Odor Identification in Older African Americans
Hawkins KA, Pearlson GD. Age and Gender but Not Common Chronic Illnesses Predict Odor Identification in Older African Americans. American Journal Of Geriatric Psychiatry 2011, 19: 777-782. PMID: 21873833, DOI: 10.1097/jgp.0b013e3181f7d8e1.Peer-Reviewed Original ResearchConceptsBrief Smell Identification TestOlder African AmericansChronic illnessBSIT scoresHealthy older African AmericansCommon chronic illnessCommon chronic conditionsLoss of smellSmell Identification TestAfrican AmericansSpecific neurodegenerative diseasesThyroid disordersChronic conditionsLimited normative dataClinical utilityOlder subjectsAge 55Odor identificationNeurodegenerative diseasesGeneral communityEarly detectionMinority cohortGlobal cognitionDemographic predictorsIdentification TestMini-Mental State Exam Performance of Older African Americans: Effect of Age, Gender, Education, Hypertension, Diabetes, and the Inclusion of Serial 7s Subtraction Versus “World” Backward on Score
Hawkins KA, Cromer JR, Piotrowski AS, Pearlson GD. Mini-Mental State Exam Performance of Older African Americans: Effect of Age, Gender, Education, Hypertension, Diabetes, and the Inclusion of Serial 7s Subtraction Versus “World” Backward on Score. Archives Of Clinical Neuropsychology 2011, 26: 645-652. PMID: 21813555, DOI: 10.1093/arclin/acr054.Peer-Reviewed Original Research
2008
Everyday Decision-Making Ability in Older Persons With Cognitive Impairment
Lai JM, Gill TM, Cooney LM, Bradley EH, Hawkins KA, Karlawish JH. Everyday Decision-Making Ability in Older Persons With Cognitive Impairment. American Journal Of Geriatric Psychiatry 2008, 16: 693-696. PMID: 18669948, PMCID: PMC2730037, DOI: 10.1097/jgp.0b013e31816c7b54.Peer-Reviewed Original ResearchConceptsDecision-making abilityDecision-making capacityCognitive impairmentMacArthur Competency Assessment ToolExecutive functionMeasure of understandingOverall cognitionAssessment of capacityValid measureAlpha coefficientMedical treatment decisionsCronbach's alpha coefficientGood reliabilityImpairmentMeasuresACEDModerate correlationOlder personsCognitionAssessment toolPersonsAbilityReasoningCaregiversEverydaySelf-Reported Distress After Cognitive Testing in Patients With Alzheimer's Disease
Lai JM, Hawkins KA, Gross CP, Karlawish JH. Self-Reported Distress After Cognitive Testing in Patients With Alzheimer's Disease. The Journals Of Gerontology Series A 2008, 63: 855-859. PMID: 18772474, PMCID: PMC2733161, DOI: 10.1093/gerona/63.8.855.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseFemaleHumansLogistic ModelsMaleNeuropsychological TestsPrevalenceRisk FactorsStress, PsychologicalConceptsSelf-reported distressCognitive testingDepressive symptomsDisease experienceSpecific patient factorsModerate AD patientsMultivariate logistic regressionCognitive performanceMore distressDemographic factorsTest performanceAlzheimer's disease (AD) experienceIntact patientsMultivariable analysisPatient factorsPatient awarenessAD patientsLevel of distressModerate ADPredictors of distressDementia severityPatientsAlzheimer's diseaseBivariate analysisLogistic regression
2006
Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care
Reid MC, Van Ness PH, Hawkins KA, Towle V, Concato J, Guo Z. Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care. Journal Of Geriatric Psychiatry And Neurology 2006, 19: 98-105. PMID: 16690995, DOI: 10.1177/0891988706286513.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionOlder male veteransBetter cognitive functionCognitive functionFormer drinkersPrimary careMale veteransModerate drinkingAlcohol consumptionBetter cognitive performanceOlder personsVeterans Administration primary care clinicCognitive performancePrimary care clinicsHopkins Verbal Learning TestCare clinicsVerbal Learning TestMean ageCurrent drinkersMedical statusOlder menReference groupLifetime useLearning TestDrinkers
2002
Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults
Reid MC, Maciejewski PK, Hawkins KA, Bogardus ST. Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults. Journal Of Geriatric Psychiatry And Neurology 2002, 15: 31-37. PMID: 11936241, DOI: 10.1177/089198870201500107.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlcohol DrinkingCognition DisordersFemaleHumansMaleMental Status ScheduleConceptsAlcohol abuse/dependenceAbuse/dependenceCognitive screenMMSE subscoresLower total MMSE scoresMMSE scoresDistinctive cognitive profileCognitive impairmentBrief cognitive screenAdverse cognitive outcomesTotal MMSE scoreAlcohol historyCognitive measuresCognitive domainsCognitive profileAlcohol consumptionMini - mental status examination testMini-Mental Status Examination scoreCognitive outcomesAlcohol abuse/dependence disordersImpaired adultsCurrent alcohol intakeMiddle-aged adultsSignificant alcohol historyComprehensive geriatric assessment
2001
The influence of IQ stratification on WAIS-III/WMS-III FSIQ-general memory index discrepancy base-rates in the standardization sample.
Hawkins KA, Tulsky DS. The influence of IQ stratification on WAIS-III/WMS-III FSIQ-general memory index discrepancy base-rates in the standardization sample. Journal Of The International Neuropsychological Society 2001, 7: 875-80. PMID: 11771631, DOI: 10.1017/s1355617701777119.Peer-Reviewed Original Research
2000
Verbal Fluency Deficits Co‐Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment
Cottingham ME, Hawkins KA. Verbal Fluency Deficits Co‐Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment. Behavioural Neurology 2000, 22: 73-79. PMID: 20595739, PMCID: PMC5434323, DOI: 10.3233/ben-2009-0246.Peer-Reviewed Original ResearchConceptsMemory deficitsMemory groupFluency performanceMild cognitive impairmentLower memory performanceCognitive impairmentPhonemic fluency taskMemory test scoresAmnestic mild cognitive impairmentAlzheimer's disease (AD) displayMemory patientsMemory performanceFluency taskMemory scoresSemantic fluencyCognitive complaintsFluency testMemory abilityFluency scoresDisease displayTest scoresDeficitsClinical presentationGeriatric patientsPatient group