2022
Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder
Fertuck E, Stanley B, Kleshchova O, Mann J, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Grinband J. Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 8: 651-659. PMID: 36868964, PMCID: PMC10388534, DOI: 10.1016/j.bpsc.2022.11.006.Peer-Reviewed Original ResearchConceptsBorderline personality disorderRejection distressFunctional magnetic resonancePrefrontal cortex responsesCortex responsesPrefrontal cortexPersonality disorderControl participantsWhole-brain responsesNeural responsesFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexHealthy control participantsUnivariate analysisMagnetic resonanceBPD groupResonance imagingNovel functional magnetic resonanceGroup differencesRostromedial prefrontal cortexNeural substratesBrain activityDistressNeural mechanisms
2020
Facial and neural mechanisms during interactive disclosure of biographical information
Cañigueral R, Zhang X, Noah JA, Tachtsidis I, Hamilton AFC, Hirsch J. Facial and neural mechanisms during interactive disclosure of biographical information. NeuroImage 2020, 226: 117572. PMID: 33221448, PMCID: PMC7612862, DOI: 10.1016/j.neuroimage.2020.117572.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCerebral CortexDisclosureEye Movement MeasurementsFacial ExpressionFacial MusclesFemaleFixation, OcularFunctional NeuroimagingHumansMaleMiddle AgedParietal LobePrefrontal CortexSelf DisclosureSignal Processing, Computer-AssistedSocial InteractionSpectroscopy, Near-InfraredTemporal LobeYoung AdultConceptsNeurocognitive mechanismsFacial displaysCommunicative interactionMore eye gazeNon-interactive situationsPairs of participantsBiographical informationBilateral TPJRight TPJLeft SMGNeuroscience hypothesisNeural mechanismsEye gazeMultimodal findingsBrain activitySocial signalingTPJDLPFCMutual sharingParticipantsSpontaneous productionLong-range mechanismsGazeDisplaySynchronyNeural processes for live pro-social dialogue between dyads with socioeconomic disparity
Descorbeth O, Zhang X, Noah JA, Hirsch J. Neural processes for live pro-social dialogue between dyads with socioeconomic disparity. Social Cognitive And Affective Neuroscience 2020, 15: 875-887. PMID: 32879986, PMCID: PMC7543936, DOI: 10.1093/scan/nsaa120.Peer-Reviewed Original ResearchConceptsDorsolateral pre-frontal cortexFrontal lobe hypothesisFrontal lobe processesFrontal lobe networksPre-frontal cortexGroups of dyadsNeural processesNovel neuroimaging techniquesFrontopolar areaNeural activationPars triangularisSpeech dialogueNeuroimaging techniquesDialectic discourseDyadsNeural functionTheoretical frameworkSocioeconomic backgroundHemodynamic signalsSocioeconomic statusAnxietyStereotypingNeuroimagingPrejudiceTriangularis
2018
Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment
Fertuck EA, Grinband J, Mann JJ, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Stanley B. Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment. NeuroImage Clinical 2018, 21: 101616. PMID: 30639176, PMCID: PMC6411618, DOI: 10.1016/j.nicl.2018.101616.Peer-Reviewed Original ResearchFunctional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation
Galgano J, Pantazatos S, Allen K, Yanagihara T, Hirsch J. Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation. Brain Research 2018, 1707: 184-189. PMID: 30500402, PMCID: PMC7434632, DOI: 10.1016/j.brainres.2018.11.040.Peer-Reviewed Original ResearchConceptsPeriaqueductal gray regionPsychophysiological interaction analysisFunctional connectivityDiffusion tensor imaging (DTI) analysisTrend-level evidenceNeural mechanismsBilateral auditory corticesGreater functional connectivityAmygdala couplingWhole-brain resultsDorsomedial prefrontal cortexLimbic systemMotor areaAmygdala clustersAuditory cortexLaryngeal musculatureHealthy adultsPrefrontal cortexNeuroimaging studiesNeural activityVoice disordersStructural connectivityGray regionCortexMovement paradigmCommunication of emotion via drumming: dual-brain imaging with functional near-infrared spectroscopy
Rojiani R, Zhang X, Noah A, Hirsch J. Communication of emotion via drumming: dual-brain imaging with functional near-infrared spectroscopy. Social Cognitive And Affective Neuroscience 2018, 13: 1047-1057. PMID: 30215809, PMCID: PMC6204489, DOI: 10.1093/scan/nsy076.Peer-Reviewed Original ResearchConceptsInternational Affective Picture SystemCommunication of emotionsTemporoparietal junction (TPJ) activationExpression of emotionsSocial neuroscienceNeuroimaging paradigmEmotional contentRight TPJHigh arousalPicture SystemValence measuresNeural responsesNonverbal communicationEmotionsNatural communicationNeural activityCommunication modalitiesJunction activationHuman interactionUnderstudied topicDrummingHemodynamic signalsEffective clinical approachContrast comparisonsTPJA cross-brain neural mechanism for human-to-human verbal communication
Hirsch J, Noah J, Zhang X, Dravida S, Ono Y. A cross-brain neural mechanism for human-to-human verbal communication. Social Cognitive And Affective Neuroscience 2018, 13: 907-920. PMID: 30137601, PMCID: PMC6137318, DOI: 10.1093/scan/nsy070.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusInteractive brain hypothesisNeural mechanismsSocial interactionBrain hypothesisCanonical language areasHuman verbal communicationNon-interactive conditionDynamic social interactionsObject NamingSocial cuesInterpersonal informationBrain substratesDescription taskTemporal gyrusBroca's areaLanguage areasWernicke's areaNeural activitySubcentral areaVerbal communicationNatural settingsTheoretical frameworkGeneral theoretical frameworkDeoxyhemoglobin signal
2017
Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact
Hirsch J, Zhang X, Noah JA, Ono Y. Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact. NeuroImage 2017, 157: 314-330. PMID: 28619652, PMCID: PMC5863547, DOI: 10.1016/j.neuroimage.2017.06.018.Peer-Reviewed Original ResearchConceptsEye contactInterpersonal interactionsSupplementary motor cortexSpecificity hypothesisFrontal clusterSubcentral areaLeft superior temporal gyrusInteractive brain hypothesisTwo-person neuroscienceLimited head motionSuperior temporal gyrusTwo-person interactionsConventional neuroimaging methodsNeural correlatesSocial cuesNeural processesBrain hypothesisNeural mechanismsNeural responsesParietal systemSupramarginal gyrusMutual gazeSynchrony hypothesisLanguage functionTemporal gyrusNeural correlates of conflict between gestures and words: A domain-specific role for a temporal-parietal complex
Noah JA, Dravida S, Zhang X, Yahil S, Hirsch J. Neural correlates of conflict between gestures and words: A domain-specific role for a temporal-parietal complex. PLOS ONE 2017, 12: e0173525. PMID: 28278240, PMCID: PMC5344449, DOI: 10.1371/journal.pone.0173525.Peer-Reviewed Original ResearchConceptsTemporal-parietal junctionDorsolateral prefrontal cortexRight temporal-parietal junctionRight dorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexSuperior temporal gyrusColor taskConflict taskIncongruent trialsSocial cuesGesture tasksSupramarginal gyrusBehavioral interference effectDomain-general mechanismsUnderlying neural processesReceptive language areasHuman social behaviorAuditory association cortexDomain-specific rolesFrontal eye fieldConflict processing mechanismCongruent trialsGestural cuesNeural correlatesNeural processes
2015
Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings
Geliebter A, Benson L, Pantazatos SP, Hirsch J, Carnell S. Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings. Appetite 2015, 96: 195-202. PMID: 26275334, PMCID: PMC4684801, DOI: 10.1016/j.appet.2015.08.009.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexHigh-calorie food cuesNon-BE groupFood cuesNeural responsesPsychophysiologic interactionsOrbitofrontal cortexFunctional connectivityGreater functional connectivityRegional brain activationAnterior cingulate activationHigh energy density foodsAnterior cingulate cortexLow-ED foodsAuditory cuesFMRI scanningActivation differencesBrain activationCingulate activationMore activationSupramarginal gyrusNeuroimaging studiesBE groupObese individualsCingulate cortexfMRI Validation of fNIRS Measurements During a Naturalistic Task
Noah JA, Ono Y, Nomoto Y, Shimada S, Tachibana A, Zhang X, Bronner S, Hirsch J. fMRI Validation of fNIRS Measurements During a Naturalistic Task. Journal Of Visualized Experiments 2015, 52116. PMID: 26132365, PMCID: PMC4544944, DOI: 10.3791/52116.Peer-Reviewed Original ResearchConceptsNaturalistic tasksBrain activityVideo game taskTask-related increasesFunctional magnetic resonanceFunctional brain activityFull-body activitiesDance Dance RevolutionFMRI scanningPsychophysical tasksNeural mechanismsGame taskFMRI procedureFNIRS experimentFNIRS measurementsFMRINaturalistic behaviorsFMRI signalsFNIRSSimple fingerTaskParadigmNeural recordingsFindingsBehaviorA pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder
Talati A, Pantazatos SP, Hirsch J, Schneier F. A pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder. Psychiatry Research 2015, 231: 279-285. PMID: 25659476, PMCID: PMC4363180, DOI: 10.1016/j.pscychresns.2015.01.008.Peer-Reviewed Original ResearchConceptsParoxetine treatmentSignificant gray matter reductionsGray matter volume changesAnxiety disordersNeuro-anatomical changesGray matter reductionsSocial anxiety disorderClinical responseLiebowitz Social Anxiety ScaleSymptom improvementRight thalamusVBM8 toolboxLeft thalamusSuccessful treatmentWeek 8Bilateral caudateControl groupGray matterDSM-IVSymptom severityLongitudinal changesPilot study
2014
Negative Blood Oxygen Level Dependent Signals During Speech Comprehension
Moreno D, Schiff ND, Hirsch J. Negative Blood Oxygen Level Dependent Signals During Speech Comprehension. Brain Connectivity 2014, 5: 232-244. PMID: 25412406, PMCID: PMC4432885, DOI: 10.1089/brain.2014.0272.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependent (BOLD) signalSpeech conditionsLevel-dependent signalBOLD signalSpeech comprehensionResting baselineNatural speechComprehension of speechCanonical language areasLanguage-related tasksNatural speech conditionNegative BOLD responseReceptive languageLanguage tasksPassive listeningComprehension studiesFrontoparietal regionsLanguage areasSame stimuliBOLD responseComprehensionBrain regionsSame speechBrief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study
Karten A, Hirsch J. Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study. Journal Of Autism And Developmental Disorders 2014, 45: 1905-1914. PMID: 25526952, PMCID: PMC4441908, DOI: 10.1007/s10803-014-2344-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNegative BOLD responseASD participantsReceptive languageLanguage disabilitySpectrum disorderNeural deactivationInhibitory processesFunctional connectivityFunctional magnetic resonance imagingBlood oxygen level-dependent (BOLD) responseSuperior temporal gyrusFunctional MRI studyLevel-dependent responsesNeural mechanismsPassive listeningTemporal gyrusBOLD responseControl participantsParticipantsLanguageMagnetic resonance imagingExcitatory processesMRI studiesConnectivityAmodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity
Carnell S, Benson L, Pantazatos SP, Hirsch J, Geliebter A. Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity. Obesity 2014, 22: 2370-2378. PMID: 25098957, PMCID: PMC4224976, DOI: 10.1002/oby.20859.Peer-Reviewed Original ResearchConceptsFunctional connectivityObese individualsFood cuesEffect of obesityLow-ED foodsWhole-brain activationGreater functional connectivityLean womenDifferential neural responsesObesogenic environmentMidbrainExcessive foodVTABrain activationNeural responsesObeseFMRI scanningObesityPutamenCerebellumActivationResponseCue modalityIndividualsWomen
2013
Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment
Pantazatos SP, Talati A, Schneier FR, Hirsch J. Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment. Neuropsychopharmacology 2013, 39: 425-434. PMID: 24084831, PMCID: PMC3870777, DOI: 10.1038/npp.2013.211.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderFunctional connectivityAnxiety disordersFace perceptionTemporal poleFunctional magnetic resonance imaging studyPanic disorderSpecific anxiety disordersIndependent replication sampleHippocampal functional connectivityMagnetic resonance imaging studyFace processingPerceptual tasksResonance imaging studyBrain activationSAD diagnosisReplication sampleHIGH-SADSAD samplesSimilar tasksDisorder-specific biomarkersFC featuresSymptom severityAnterior temporalPerceptionShared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults
Hamberger MJ, Habeck CG, Pantazatos SP, Williams AC, Hirsch J. Shared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults. Human Brain Mapping 2013, 35: 2507-2520. PMID: 23918095, PMCID: PMC4091775, DOI: 10.1002/hbm.22345.Peer-Reviewed Original ResearchConceptsVisual namingVisual objectsAuditory descriptionActivation patternsPosterior temporal activationNeural activation patternsCommon neural substrateTask-related differencesTask-specific regionsPosterior temporal regionsAnterior temporal cortexTypes of tasksCortical stimulation studiesTemporo-parietal regionsTemporal lobe epilepsy patientsHealthy adultsCognitive scientistsStandard univariate analysisNeural processesNeural substratesFunctional neuroimagingCerebral organizationTask specificityTemporal cortexLeft posteriorSleep restriction increases the neuronal response to unhealthy food in normal-weight individuals
St-Onge M, Wolfe S, Sy M, Shechter A, Hirsch J. Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals. International Journal Of Obesity 2013, 38: 411-416. PMID: 23779051, PMCID: PMC3883872, DOI: 10.1038/ijo.2013.114.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFood stimuliRight insulaUnhealthy foodsUnhealthy food stimuliNormal-weight individualsMiddle temporal gyrusLevel-dependent activityInferior parietal lobuleSuperior frontal gyrusInsula activityFrontal gyrusGreater activationNeural mechanismsTemporal gyrusParietal lobuleFood intakeOrbitofrontal cortexRestricted sleepSame stimuliNeuronal responsesSleep restrictionNeural systemsBrain rewardShort sleep durationDynamic Coupling Between the Lateral Occipital-Cortex, Default-Mode, and Frontoparietal Networks During Bistable Perception
Karten A, Pantazatos SP, Khalil D, Zhang X, Hirsch J. Dynamic Coupling Between the Lateral Occipital-Cortex, Default-Mode, and Frontoparietal Networks During Bistable Perception. Brain Connectivity 2013, 3: 286-293. PMID: 23510237, PMCID: PMC3685318, DOI: 10.1089/brain.2012.0119.Peer-Reviewed Original ResearchEffects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans. PLOS ONE 2013, 8: e59114. PMID: 23555620, PMCID: PMC3605420, DOI: 10.1371/journal.pone.0059114.Peer-Reviewed Original ResearchConceptsLeptin repletionRight hypothalamusFunctional connectivityFood cuesWeight lossGreater weight lossOrbital frontal cortexDorsal anterior cingulatePsychophysiological interaction analysisPlacebo injectionsObese subjectsObese populationLeptin injectionObese humansWeight maintenanceFrontal cortexAnterior cingulateHypothalamusFrontal poleInteroceptive systemPatient subjectsVisual areasDorsal ACCFood stimuliRepletion