2022
Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder
Fertuck E, Stanley B, Kleshchova O, Mann J, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Grinband J. Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 8: 651-659. PMID: 36868964, PMCID: PMC10388534, DOI: 10.1016/j.bpsc.2022.11.006.Peer-Reviewed Original ResearchConceptsBorderline personality disorderRejection distressFunctional magnetic resonancePrefrontal cortex responsesCortex responsesPrefrontal cortexPersonality disorderControl participantsWhole-brain responsesNeural responsesFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexHealthy control participantsUnivariate analysisMagnetic resonanceBPD groupResonance imagingNovel functional magnetic resonanceGroup differencesRostromedial prefrontal cortexNeural substratesBrain activityDistressNeural mechanismsDecreased Exercise-Induced Changes in Prefrontal Cortex Hemodynamics Are Associated With Depressive Symptoms
Crum J, Ronca F, Herbert G, Funk S, Carmona E, Hakim U, Jones I, Hamer M, Hirsch J, Hamilton A, Tachtsidis I, Burgess P. Decreased Exercise-Induced Changes in Prefrontal Cortex Hemodynamics Are Associated With Depressive Symptoms. Frontiers In Neuroergonomics 2022, 3: 806485. PMID: 38235451, PMCID: PMC10790946, DOI: 10.3389/fnrgo.2022.806485.Peer-Reviewed Original ResearchCardiopulmonary exercise testPhysical activityDepressive symptomsPrefrontal cortexActivation changesRostral prefrontal cortexExercise-induced changesExecutive function tasksMental health interventionsPrefrontal cortex hemodynamicsExecutive functionCPET assessmentFunction tasksAcute exerciseFunction testsExercise testAcute effectsInferior frontal gyrusExecutive function testsHealth interventionsNeural effectsAerobic fitnessDepressed moodSymptomsPhysical fitnessAn Approach to Neuroimaging Interpersonal Interactions in Mental Health Interventions
Crum J, Zhang X, Noah A, Hamilton A, Tachtsidis I, Burgess PW, Hirsch J. An Approach to Neuroimaging Interpersonal Interactions in Mental Health Interventions. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 669-679. PMID: 35144035, PMCID: PMC9271588, DOI: 10.1016/j.bpsc.2022.01.008.Peer-Reviewed Original ResearchConceptsInterpersonal interactionsPrefrontal cortexRostral prefrontal cortexInferior parietal lobuleMental health interventionsNeural underpinningsDysfunctional cognitionsBrain systemsEcological validityPrefrontal systemsParietal lobuleNeural couplingNeuroimaging techniquesVerbal communicationVerbal interactionClinical neuroscienceMental healthCortexClinical situationsClinical settingClinical tasksClinical interactionsParadigmHealth interventionsCognition
2021
Comparison of Human Social Brain Activity During Eye-Contact With Another Human and a Humanoid Robot
Kelley MS, Noah JA, Zhang X, Scassellati B, Hirsch J. Comparison of Human Social Brain Activity During Eye-Contact With Another Human and a Humanoid Robot. Frontiers In Robotics And AI 2021, 7: 599581. PMID: 33585574, PMCID: PMC7879449, DOI: 10.3389/frobt.2020.599581.Peer-Reviewed Original ResearchNeural activitySocial interactionCognitive processingEye contactNeural systemsRight temporal-parietal junctionHuman-robot social interactionRight temporoparietal junctionSame neural systemsTemporal-parietal junctionInterpersonal social interactionsSimilar neural activityDorsolateral prefrontal cortexHuman-robot interactionHuman social systemsSocial processingParietal junctionTemporoparietal junctionSocial robotsNeural responsesNeural effectsRobot conditionBrain activityPrefrontal cortexSocial engagementInterpersonal Agreement and Disagreement During Face-to-Face Dialogue: An fNIRS Investigation
Hirsch J, Tiede M, Zhang X, Noah JA, Salama-Manteau A, Biriotti M. Interpersonal Agreement and Disagreement During Face-to-Face Dialogue: An fNIRS Investigation. Frontiers In Human Neuroscience 2021, 14: 606397. PMID: 33584223, PMCID: PMC7874076, DOI: 10.3389/fnhum.2020.606397.Peer-Reviewed Original ResearchSupramarginal gyrusAttention networkBilateral dorsolateral prefrontal cortexLanguage-related processesCanonical language areasVisual attention networkRight supramarginal gyrusDorsolateral prefrontal cortexSuperior temporal gyrusFNIRS investigationFrontoparietal systemNeural correlatesSocial cuesAngular gyrusTemporal gyrusPrefrontal cortexLanguage areasFrontopolar regionNeural systemsSyllable rateNeural activityMedian fundamental frequencyFace conversationNeural couplingLanguage system
2018
Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment
Fertuck EA, Grinband J, Mann JJ, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Stanley B. Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment. NeuroImage Clinical 2018, 21: 101616. PMID: 30639176, PMCID: PMC6411618, DOI: 10.1016/j.nicl.2018.101616.Peer-Reviewed Original ResearchFunctional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation
Galgano J, Pantazatos S, Allen K, Yanagihara T, Hirsch J. Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation. Brain Research 2018, 1707: 184-189. PMID: 30500402, PMCID: PMC7434632, DOI: 10.1016/j.brainres.2018.11.040.Peer-Reviewed Original ResearchConceptsPeriaqueductal gray regionPsychophysiological interaction analysisFunctional connectivityDiffusion tensor imaging (DTI) analysisTrend-level evidenceNeural mechanismsBilateral auditory corticesGreater functional connectivityAmygdala couplingWhole-brain resultsDorsomedial prefrontal cortexLimbic systemMotor areaAmygdala clustersAuditory cortexLaryngeal musculatureHealthy adultsPrefrontal cortexNeuroimaging studiesNeural activityVoice disordersStructural connectivityGray regionCortexMovement paradigm
2015
Motor learning and modulation of prefrontal cortex: an fNIRS assessment
Ono Y, Noah JA, Zhang X, Nomoto Y, Suzuki T, Shimada S, Tachibana A, Bronner S, Hirsch J. Motor learning and modulation of prefrontal cortex: an fNIRS assessment. Journal Of Neural Engineering 2015, 12: 066004. PMID: 26401727, DOI: 10.1088/1741-2560/12/6/066004.Peer-Reviewed Original ResearchConceptsDance video gameHemodynamic responsePrefrontal cortexMotor tasksMotor learningMotor performanceSpecific rehabilitation programPrefrontal hemodynamic responsesBaseline patternsHealthy young adultsTraining-induced changesComplex motor tasksRehabilitation programYoung adultsRegression analysisCortexRegression modelsAuditory cuesNovice playersSensitive indicatorResponseParticipantsBrain activity classifies adolescents with and without a familial history of substance use disorders
Qiao J, Wang Z, Geronazzo-Alman L, Amsel L, Duarte C, Lee S, Musa G, Long J, He X, Doan T, Hirsch J, Hoven CW. Brain activity classifies adolescents with and without a familial history of substance use disorders. Frontiers In Human Neuroscience 2015, 9: 219. PMID: 25954186, PMCID: PMC4406072, DOI: 10.3389/fnhum.2015.00219.Peer-Reviewed Original ResearchAnterior cingulate cortexSubstance use disordersPrefrontal cortexEmotional conflictBrain circuitsEmotional Stroop taskPotential neurobiological mechanismsFunctional magnetic resonanceUse disordersGroup-level analysisStroop taskVentral tegmental areaNeural substratesCognitive behaviorNeurobiological mechanismsBrain activityEffective connectivityEndophenotype markersCingulate cortexBrain featuresGranger causality indexWeak connectivityFH- adolescentsAdolescentsCausal interactions
2012
Frontal–Occipital Connectivity During Visual Search
Pantazatos SP, Yanagihara TK, Zhang X, Meitzler T, Hirsch J. Frontal–Occipital Connectivity During Visual Search. Brain Connectivity 2012, 2: 164-175. PMID: 22708993, PMCID: PMC3621345, DOI: 10.1089/brain.2012.0072.Peer-Reviewed Original ResearchConceptsLateral occipital cortexVisual searchVisual regionsPrefrontal cortexCategory-selective visual regionsFunctional magnetic resonance imagingVentromedial prefrontal cortexSimilar neural mechanismsVisual search processDynamic causal modelingMedial prefrontal cortexComplex natural scenesMultiple task-related componentsSpatial independent component analysisTask-related componentsVisual imageryPsychophysiological interactionNeural mechanismsSearch taskObject categoriesComplex search tasksCausal modelingConnectivity findingsFrontal regionsFunctional connectivityDecoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity. PLOS Computational Biology 2012, 8: e1002441. PMID: 22479172, PMCID: PMC3315448, DOI: 10.1371/journal.pcbi.1002441.Peer-Reviewed Original ResearchConceptsFearful facesEmotional expressionBilateral middle temporal gyrusThreat-related stimuliUnattended fearful facesLarge-scale functional connectivityMultiple functional connectionsFunctional magnetic resonanceWhole-brain patternsMiddle temporal gyrusWhole-brain correlationActive research goalNeutral facesEmotion processingFear perceptionImplicit fearImplicit presentationAngular gyrusChance accuracyTemporal gyrusBrain activityFace presentationPrefrontal cortexParietal regionsFunctional connectivitySleep restriction leads to increased activation of brain regions sensitive to food stimuli
St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy M, Hirsch J. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. American Journal Of Clinical Nutrition 2012, 95: 818-824. PMID: 22357722, PMCID: PMC3302360, DOI: 10.3945/ajcn.111.027383.Peer-Reviewed Original ResearchConceptsFood stimuliNeuronal activityHabitual sleepSleep restrictionNormal-weight menOverall neuronal activityAverage sleep durationFunctional magnetic resonance imagingMagnetic resonance imagingPartial sleep restrictionCrossover studyEpidemiologic evidenceClinical studiesNeuronal activationNucleus accumbensSleep durationFasted stateResonance imagingBrain regionsDay 6Prefrontal cortexSleepBrain activityRelative increaseStimuli
2010
A translational bridge between mouse and human models of learned safety
Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Annals Of Medicine 2010, 42: 127-134. PMID: 20121549, DOI: 10.3109/07853890903583666.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexNeural circuitryPrefrontal cortexAnimal experimentsTranslational bridgeFunctional magnetic resonanceParallel groupSafety signalsPupillary constrictionNoxious stimuliUnderlying neural circuitryHuman studiesExperimental animalsHuman modelNeural connectionsAnimal protocolsMiceCaudate responseNeutral stimuliNeural responsesNeural substratesDiffusion tensorAmygdalaCortexMolecular mechanisms
2009
Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze
Schneier FR, Kent JM, Star A, Hirsch J. Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze. Psychiatry Research 2009, 173: 248-250. PMID: 19628377, PMCID: PMC2745296, DOI: 10.1016/j.pscychresns.2008.06.004.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderEye gazeAnxiety disordersPathophysiology of SADSubmissive behaviorFunctional magnetic resonance imagingDirect eye gazeAverted gazeDirect gazeNeural responsesPrefrontal cortexSAD subjectsAnterior cingulateNeural circuitryNeural activityBrain regionsGazeMagnetic resonance imagingHealthy volunteersResonance imagingDisordersInsulaCingulateFearSignificant differences
2007
Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters
Egner T, Etkin A, Gale S, Hirsch J. Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters. Cerebral Cortex 2007, 18: 1475-1484. PMID: 17940084, DOI: 10.1093/cercor/bhm179.Peer-Reviewed Original ResearchConceptsTask-relevant stimuliEmotional distractersTask-irrelevant emotional stimuliAnterior cingulateSensory cortexTask-irrelevant stimuliLateral prefrontal cortexDorsal anterior cingulateFunctional magnetic resonanceRostral anterior cingulateCognitive controlConflict monitoringEmotional stimuliStimulus representationsAmygdalar responsesEmotional controlEnhanced processingResolve ConflictsEmotional conflictNeuroanatomical networksPrefrontal cortexDistractersResolution of conflictsBiasing mechanismHuman brainPreparatory neural activity predicts performance on a conflict task
Stern ER, Wager TD, Egner T, Hirsch J, Mangels JA. Preparatory neural activity predicts performance on a conflict task. Brain Research 2007, 1176: 92-102. PMID: 17889835, PMCID: PMC2288660, DOI: 10.1016/j.brainres.2007.07.060.Peer-Reviewed Original ResearchConceptsPreparatory neural activityBilateral parietal cortexPreparatory activationNeutral cuesNeural activityParietal cortexRight dorsolateral prefrontal cortexReaction timeSpatial Stroop taskTask-relevant informationConflict resolutionDorsolateral prefrontal cortexTask-specific networksEfficient conflict resolutionConflict stimuliAdvance cuesCueing effectsStroop taskConflict taskAdvance cueingInformative cuesAnterior prefrontalLittle empirical workSemantic cuesPrefrontal cortex
2006
Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala
Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala. Neuron 2006, 51: 871-882. PMID: 16982430, DOI: 10.1016/j.neuron.2006.07.029.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingCingulate cortexEmotional conflictAmygdalar activityRostral cingulate cortexMagnetic resonance imagingDorsolateral prefrontal cortexRostral cingulateResonance imagingPrefrontal cortexModulating activityCortexConflict taskSalient stimuliNeural activityNeural mechanismsMental functioningActivationConflictActivityAmygdalaNeocortical Connectivity during Episodic Memory Formation
Summerfield C, Greene M, Wager T, Egner T, Hirsch J, Mangels J. Neocortical Connectivity during Episodic Memory Formation. PLOS Biology 2006, 4: e128. PMID: 16605307, PMCID: PMC1436028, DOI: 10.1371/journal.pbio.0040128.Peer-Reviewed Original ResearchConceptsEpisodic encodingPerceptual informationEpisodic memory tracesLeft dorsolateral prefrontal cortexNew episodic memoriesEpisodic memory formationFunctional magnetic resonanceDorsolateral prefrontal cortexExtrastriate visual cortexEpisodic memoryMemory tracesBrain mechanismsSensory representationsVisual stimuliPrefrontal cortexConnectivity analysisMemory formationVisual cortexNeocortical connectivityEncodingHemodynamic signalsCortexReliable predictorMemorySelective response
2005
Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information
Egner T, Hirsch J. Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nature Neuroscience 2005, 8: 1784-1790. PMID: 16286928, DOI: 10.1038/nn1594.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBehaviorBrain MappingCerebral CortexCerebrovascular CirculationCognitionConflict, PsychologicalDecision MakingFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysNeuropsychological TestsPattern Recognition, VisualPhotic StimulationPrefrontal CortexReaction TimeVisual CortexVolitionConceptsTask-relevant informationCognitive control mechanismsTask-irrelevant informationCognitive controlTask-relevant stimulus informationCognitive control systemConflict resolutionDorsolateral prefrontal cortexHuman visual cortexAttentional biasingFace processingPerceptual processingFace stimuliStroop taskNeural representationStimulus informationResponse tendenciesOccurrence of conflictsHigh conflictPrefrontal cortexProminent modelsCortical responsesTrial levelCortical amplificationVisual cortexIntentional false responding shares neural substrates with response conflict and cognitive control
Nuñez JM, Casey BJ, Egner T, Hare T, Hirsch J. Intentional false responding shares neural substrates with response conflict and cognitive control. NeuroImage 2005, 25: 267-277. PMID: 15734361, DOI: 10.1016/j.neuroimage.2004.10.041.Peer-Reviewed Original ResearchMeSH KeywordsAdultArousalAutobiographies as TopicBrainCaudate NucleusConflict, PsychologicalDeceptionDominance, CerebralFemaleGyrus CinguliHumansImage Processing, Computer-AssistedIntentionInternal-External ControlMagnetic Resonance ImagingMaleNerve NetNeural InhibitionParietal LobePersonality InventoryPrefrontal CortexReaction TimeTemporal LobeThalamic NucleiConceptsDorsolateral prefrontal cortexCognitive controlResponse conflictAnterior cingulate cortexPsychopathic Personality InventoryCingulate cortexSelf-report personality measuresSelf-relevant stimuliFalse responsesAmount of conflictPosterior cingulate cortexResponse inhibitionNeural substratesCaudate activityMesial prefrontalNeural effectsPersonality measuresCognitive functionPersonal relevancePrefrontal cortexAnterior cingulateNeural activityAutobiographical responsesProcess of interferenceResponse conditions