2022
Neural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelates
2021
Comparison of Human Social Brain Activity During Eye-Contact With Another Human and a Humanoid Robot
Kelley MS, Noah JA, Zhang X, Scassellati B, Hirsch J. Comparison of Human Social Brain Activity During Eye-Contact With Another Human and a Humanoid Robot. Frontiers In Robotics And AI 2021, 7: 599581. PMID: 33585574, PMCID: PMC7879449, DOI: 10.3389/frobt.2020.599581.Peer-Reviewed Original ResearchNeural activitySocial interactionCognitive processingEye contactNeural systemsRight temporal-parietal junctionHuman-robot social interactionRight temporoparietal junctionSame neural systemsTemporal-parietal junctionInterpersonal social interactionsSimilar neural activityDorsolateral prefrontal cortexHuman-robot interactionHuman social systemsSocial processingParietal junctionTemporoparietal junctionSocial robotsNeural responsesNeural effectsRobot conditionBrain activityPrefrontal cortexSocial engagement
2020
Joint Attention During Live Person-to-Person Contact Activates rTPJ, Including a Sub-Component Associated With Spontaneous Eye-to-Eye Contact
Dravida S, Noah JA, Zhang X, Hirsch J. Joint Attention During Live Person-to-Person Contact Activates rTPJ, Including a Sub-Component Associated With Spontaneous Eye-to-Eye Contact. Frontiers In Human Neuroscience 2020, 14: 201. PMID: 32581746, PMCID: PMC7283505, DOI: 10.3389/fnhum.2020.00201.Peer-Reviewed Original ResearchJoint attention taskAttention taskJoint attentionEye contactSocial behaviorHigh-level visual areasJoint attention conditionRight temporoparietal junctionNon-social conditionEye contact behaviorEye gaze behaviorMore eye contactLow eye contactSpectroscopy hyperscanningUse of eyeAttention systemTemporoparietal junctionAttention activitiesAttention conditionObject of attentionHigh eye contactLED cuePartner's attentionAttention resultsGaze behaviorReal-Time Eye-to-Eye Contact Is Associated With Cross-Brain Neural Coupling in Angular Gyrus
Noah JA, Zhang X, Dravida S, Ono Y, Naples A, McPartland JC, Hirsch J. Real-Time Eye-to-Eye Contact Is Associated With Cross-Brain Neural Coupling in Angular Gyrus. Frontiers In Human Neuroscience 2020, 14: 19. PMID: 32116606, PMCID: PMC7016046, DOI: 10.3389/fnhum.2020.00019.Peer-Reviewed Original ResearchTemporal-parietal junctionAngular gyrusEye contactRight temporal-parietal junctionNeural couplingInteractive behaviorDirect eye contactDynamic videosNeural processesNeural mechanismsEye gazeInterpersonal interactionsHuman participantsReal-time eyeSocial behaviorNeural signalsTime eyesFace videosGyrusTheoretical frameworkCoupling hypothesisGeneral theoretical frameworkParticipantsEye conditionsProcessing system
2017
Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact
Hirsch J, Zhang X, Noah JA, Ono Y. Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact. NeuroImage 2017, 157: 314-330. PMID: 28619652, PMCID: PMC5863547, DOI: 10.1016/j.neuroimage.2017.06.018.Peer-Reviewed Original ResearchConceptsEye contactInterpersonal interactionsSupplementary motor cortexSpecificity hypothesisFrontal clusterSubcentral areaLeft superior temporal gyrusInteractive brain hypothesisTwo-person neuroscienceLimited head motionSuperior temporal gyrusTwo-person interactionsConventional neuroimaging methodsNeural correlatesSocial cuesNeural processesBrain hypothesisNeural mechanismsNeural responsesParietal systemSupramarginal gyrusMutual gazeSynchrony hypothesisLanguage functionTemporal gyrus
2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulate