Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
Batista-Brito R, Majumdar A, Nuño A, Ward C, Barnes C, Nikouei K, Vinck M, Cardin J. Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics. Molecular Psychiatry 2023, 28: 3133-3143. PMID: 37069344, PMCID: PMC10618960, DOI: 10.1038/s41380-023-02066-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsInterneuronsMiceNeuregulin-1NeuronsParvalbuminsPyramidal CellsReceptor, ErbB-4Signal TransductionConceptsPV interneuronsCortical neuronsCortical circuitsCortical circuit dynamicsCortical GABAergic cellsNRG1/ErbB4Excitatory cortical neuronsParvalbumin-Expressing InterneuronsInhibitory cortical neuronsApical dendritic tuftsActivity of excitatorySecond postnatal weekProper synaptic connectivityLate postnatal developmentState-dependent modulationLoss of ERBB4Excitatory componentGABAergic cellsGABAergic inhibitionSpine densityDendritic tuftsPostnatal weekNormal tuningSynaptic connectivityReceptor ErbB4