2023
VIP interneurons regulate cortical size tuning and visual perception
Ferguson K, Salameh J, Alba C, Selwyn H, Barnes C, Lohani S, Cardin J. VIP interneurons regulate cortical size tuning and visual perception. Cell Reports 2023, 42: 113088. PMID: 37682710, PMCID: PMC10618959, DOI: 10.1016/j.celrep.2023.113088.Peer-Reviewed Original ResearchConceptsState-dependent modulationPyramidal neuronsVIP-INsBehavioral state-dependent modulationCortical circuit functionVasoactive intestinal peptidePrimary visual cortexAwake behaving miceIntestinal peptideGABAergic interneuronsVIP interneuronsCortical activityVisual cortexBehaving miceFeature selectivityInterneuronsSensory processingSpecialized populationCircuit functionStimulus sizeActivity altersDiverse populationsModulationPopulationCortexPutting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity
Perrenoud Q, Cardin J. Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity. Neuron 2023, 111: 297-299. PMID: 36731427, DOI: 10.1016/j.neuron.2023.01.004.Peer-Reviewed Original Research
2018
Altered hippocampal interneuron activity precedes ictal onset
Miri ML, Vinck M, Pant R, Cardin J. Altered hippocampal interneuron activity precedes ictal onset. ELife 2018, 7: e40750. PMID: 30387711, PMCID: PMC6245730, DOI: 10.7554/elife.40750.Peer-Reviewed Original ResearchConceptsSynaptic inhibitionIctal activityEarly ictal phaseHippocampal interneuron activityLocal circuit interactionsSomatostatin-expressing (SST) interneuronsInhibitory interneuron populationsSeizure inductionGABAergic inhibitionSeizure disorderIctal onsetSource of inhibitionSeizure initiationIctal phaseHippocampal circuitsInterneuron activityInterneuron populationsInterneuron classesFiring patternsInterneuronsElectrophysiological approachesPreictal periodInhibitionParvalbuminOnset
2010
Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons
Cardin JA, Kumbhani RD, Contreras D, Palmer LA. Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons. Journal Of Neuroscience 2010, 30: 3652-3662. PMID: 20219999, PMCID: PMC2880457, DOI: 10.1523/jneurosci.5279-09.2010.Peer-Reviewed Original ResearchConceptsLayer 4 neuronsCortical neuronsSensory-evoked synaptic inputsVisual cortex neuronsCellular mechanismsPrimary visual cortexCortex neuronsInhibitory interneuronsCortical functionExcitatory neuronsSynaptic inputsMembrane potential responsesSpike precisionVisual cortexCortical layersExcitatory conductanceNeuronsCoincident inputsInput integrationSynchronous inputsCortexNonlinear summationTemporal sensitivityAcuityInterneurons