2022
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani S, Moberly A, Benisty H, Landa B, Jing M, Li Y, Higley M, Cardin J. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. Nature Neuroscience 2022, 25: 1706-1713. PMID: 36443609, PMCID: PMC10661869, DOI: 10.1038/s41593-022-01202-6.Peer-Reviewed Original ResearchConceptsCortical network activityBehavioral statesCholinergic modulationAnimal's behavioral stateCholinergic signalingAwake miceCortical functionFunctional reorganizationNeuromodulatory influencesDifferent motor behaviorsNeocortical activityAcetylcholineMotor behaviorCortical networksRecent evidenceBrain activityFunctional segregationNeocortexMesoscopic imagingHeterogeneous signalsNetwork activityBehavioral markersBehavioral variablesCircuit dynamicsCholinergic
2015
Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology
Furman M, Zhan Q, McCafferty C, Lerner BA, Motelow JE, Meng J, Ma C, Buchanan GF, Witten IB, Deisseroth K, Cardin JA, Blumenfeld H. Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Epilepsia 2015, 56: e198-e202. PMID: 26530287, PMCID: PMC4679683, DOI: 10.1111/epi.13220.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresLimbic seizuresCortical functionBrainstem neuronsCortical dysfunctionFocal temporal lobe seizuresOptogenetic stimulationCortical slow-wave activityDepressed cortical functionSubcortical cholinergic neuronsTemporal lobe seizuresLoss of consciousnessPedunculopontine tegmental nucleusAnesthetized rat modelSlow wave activityCortical gamma activitySleep-like stateCholinergic neuronsFocal seizuresArousal networkCholinergic stimulationTegmental nucleusRat modelCortical physiologySeizures
2010
Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons
Cardin JA, Kumbhani RD, Contreras D, Palmer LA. Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons. Journal Of Neuroscience 2010, 30: 3652-3662. PMID: 20219999, PMCID: PMC2880457, DOI: 10.1523/jneurosci.5279-09.2010.Peer-Reviewed Original ResearchConceptsLayer 4 neuronsCortical neuronsSensory-evoked synaptic inputsVisual cortex neuronsCellular mechanismsPrimary visual cortexCortex neuronsInhibitory interneuronsCortical functionExcitatory neuronsSynaptic inputsMembrane potential responsesSpike precisionVisual cortexCortical layersExcitatory conductanceNeuronsCoincident inputsInput integrationSynchronous inputsCortexNonlinear summationTemporal sensitivityAcuityInterneurons