2024
Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024 PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisorders
2012
Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence
Petrakis I, Ralevski E. Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence. 2012 DOI: 10.21236/ada568060.Peer-Reviewed Original ResearchAlpha-1 adrenergic receptor antagonistComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistAlcohol consumptionDouble-blind fashionCommon comorbid conditionsTreatment of patientsRates of PTSDCommon neurobiological mechanismsTraumatic Stress DisorderSymptoms of PTSDComorbid conditionsSleep disturbancesEffective treatmentGeneral populationTrauma nightmaresPrazosinCurrent diagnosisPatientsStress disorderNeurobiological mechanismsPTSD symptomsSymptoms
2011
Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence
Petrakis I. Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence. 2011 DOI: 10.21236/ada554540.Peer-Reviewed Original ResearchComorbid alcohol dependenceAdrenergic receptor antagonistAlcohol dependenceReceptor antagonistSymptoms of PTSDAlcohol consumptionTraumatic Stress DisorderCommon neurobiological mechanismsDouble-blind fashionRates of PTSDTreatment of patientsPTSD symptomsStress disorderNeurobiological mechanismsCombat veteransPTSDCommon comorbidTrauma nightmaresSleep disturbancesEffective treatmentGeneral populationPrazosinCurrent diagnosisPatientsSymptoms
2001
Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients
Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.Peer-Reviewed Original ResearchConceptsCue-induced cravingAlcohol-dependent patientsTryptophan depletionAlcohol cue-induced cravingDouble-blind fashionPlasma free tryptophanAbstinent alcoholic patientsAmino acid drinkActive tryptophan depletionAlcoholic patientsSerotonin synthesisAcid drinkSober alcoholicsAlcoholic individualsPrecursor tryptophanCue exposurePatientsAlcohol useAbstinent alcoholic individualsCravingFree tryptophanAlcohol cuesTest dayGreater increaseSimilar drinks