2022
Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume
Villa L, Colic L, Kim J, Sankar A, Goldman D, Lessing B, Pittman B, Alexopoulos G, van Dyck C, Blumberg H. Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume. Journal Of Affective Disorders 2022, 323: 875-883. PMID: 36526112, PMCID: PMC9839524, DOI: 10.1016/j.jad.2022.12.026.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderBrainCross-Sectional StudiesGray MatterHumansMagnetic Resonance ImagingConceptsGray matter volumeOccipital cortical thicknessSubcortical gray matter volumesCortical thicknessBipolar disorderMatter volumeOlder adultsOnset of BDIndividuals age 40Striatal gray matter volumeGray matter reductionsOnset bipolar disorderGray matter decreasesPrefrontal cortical thicknessStructural brain differencesHigh suicide riskCross-sectional designHealthy controlsCognitive dysfunctionTreatment resistanceAge 40Striatal volumeSevere symptomsSuicide attempt historySuicide attemptsDifferences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder
Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderDepressive Disorder, MajorHumansMagnetic Resonance ImagingPositron-Emission TomographyPrefrontal CortexReceptor, Metabotropic Glutamate 5ConceptsMajor depressive disorderMetabotropic glutamate receptor 5Glutamate receptor 5MGluR5 availabilityBipolar disorderPositron emission tomographyHC groupDepressive disorderReceptor 5Emission tomographyHealthy control individualsPossible treatment targetsGlutamate transmissionBD depressionTreatment strategiesBD groupMGluR5Depressive symptomsNovel treatmentsCognitive alterationsTreatment targetsSynaptic plasticityControl individualsAccurate diagnosisSignificant negative correlationA graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrainDepressive Disorder, MajorHumansMagnetic Resonance ImagingNeuroimagingYoung AdultConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatmentGender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder
Colic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder. European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainChildChild AbuseFemaleGray MatterHumansMagnetic Resonance ImagingMalePrefrontal CortexConceptsClinical featuresBipolar disorderCM severityChildhood maltreatmentLeft hippocampusPost-traumatic stress disorder (PTSD) comorbidityBrain structuresStructural magnetic resonance imagingGender-related associationMagnetic resonance imagingGray matter structuresChildhood Trauma QuestionnaireGender-related differencesCM exposureHealthy controlsClinical assessmentDisorder comorbidityMood symptomsPathophysiological modelGender-related effectsResonance imagingHippocampusFrontal poleTrauma QuestionnaireSeverityDorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients
Dhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H. Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients. Epilepsia 2022, 63: 2561-2570. PMID: 35883245, DOI: 10.1111/epi.17377.Peer-Reviewed Original ResearchMeSH KeywordsDepressive Disorder, MajorElectroencephalographyEpilepsyEpilepsy, Temporal LobeHumansMagnetic Resonance ImagingSeptal NucleiConceptsTemporal lobe epilepsyDorsal bed nucleusTLE patientsEpilepsy patientsBed nucleusHC subjectsStria terminalisTemporal lobe epilepsy patientsMini International Neuropsychiatric InterviewMagnetic resonance imaging (MRI) scansTreatment-resistant depressionComprehensive Epilepsy CenterHealthy control subjectsStructural magnetic resonance imaging (MRI) scansResonance imaging scansNumber of patientsCase-control studyInternational Neuropsychiatric InterviewMajor depressive disorderCommon comorbid disordersHuman clinical studiesEpilepsy centersLobe epilepsyComorbid depressionControl subjectsGraph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder
Sankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder. Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainHumansMagnetic Resonance ImagingPrefrontal CortexSuicide, AttemptedConceptsIntrinsic connectivity distributionBipolar disorderSuicide attemptsHealthy volunteersFunctional connectivity disturbancesSuicide behaviorWhole-brain functional connectivityPrior suicide attemptsRight anterior insulaBrain functional connectivitySuicidal ideation severityBilateral ventromedial prefrontal cortexFunctional magnetic resonanceSignificant group differencesTemporopolar cortexConnectivity disturbancesBrain targetsFC differencesHigh riskCerebellar cortexVentromedial prefrontal cortexSuicidal ideationOrbitofrontal cortexFunctional connectivitySuicide risk
2021
A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrainBrain MappingHumansMagnetic Resonance ImagingPrefrontal CortexYoung AdultConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regions
2020
What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
Ching CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, de Zwarte S, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro‐de‐Souza M, Tronchin G, van Haren N, Vieta E, Walter H, Zeng L, Alda M, Almeida J, Alnæs D, Alonso‐Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, del Mar Bonnin C, Brambilla P, Canales‐Rodríguez E, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz‐Zuluaga A, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives‐Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López‐Jaramillo C, Machado‐Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda‐Zapata J, Poletti S, Polosan M, Pomarol‐Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu M, Yatham LN, Zarate CA, Thompson PM, Andreassen OA, Group E. What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping 2020, 43: 56-82. PMID: 32725849, PMCID: PMC8675426, DOI: 10.1002/hbm.25098.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderCerebral CortexHumansMagnetic Resonance ImagingMeta-Analysis as TopicMulticenter Studies as TopicNeuroimagingConceptsStudies of BDBipolar disorderClinical risk profileLower cortical thicknessMultimodal brain MRIFuture hypothesis-driven studiesWhite matter integrityWorking GroupCommon medicationsPathophysiological mechanismsEnhancing Neuro Imaging GeneticsBrain alterationsBrain MRICortical thicknessSubcortical volumesSymptom patternsMental illnessRisk profileBrain measuresGroup studyHypothesis-driven studiesConsensus findingsPool dataBrain variationMRIAltered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder
Sankar A, Purves K, Colic L, Lippard ETC, Millard H, Fan S, Spencer L, Wang F, Pittman B, Constable RT, Gross JJ, Blumberg HP. Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder. Bipolar Disorders 2020, 23: 152-164. PMID: 32521570, PMCID: PMC7790437, DOI: 10.1111/bdi.12954.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderBrainEmotional RegulationEmotionsFrontal LobeHumansMagnetic Resonance ImagingConceptsExplicit emotion regulationEmotion regulationBrain responsesMood statesDorsal anterior cingulate cortexEmotion regulation difficultiesHappy facial stimuliFrontal cortex functioningDorsal frontal regionsBipolar disorderAcute mood symptomsAnterior cingulate cortexFunctional MRI dataMajor suicide risk factorsNegative affective symptomsEuthymic mood stateRegional brain responsesFacial stimuliRegulation difficultiesFrontal engagementMOFC responseNegative emotionsLoss of motivationDiminished motivationEuthymic individuals
2019
A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulation
Chung YS, Poppe A, Novotny S, Epperson CN, Kober H, Granger DA, Blumberg HP, Ochsner K, Gross JJ, Pearlson G, Stevens MC. A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulation. Psychoneuroendocrinology 2019, 109: 104398. PMID: 31394491, PMCID: PMC6842698, DOI: 10.1016/j.psyneuen.2019.104398.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCognitionEmotional RegulationEmotionsEstradiolFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingPrefrontal CortexPreliminary DataConceptsDorsolateral prefrontal cortexNegative emotionsDLPFC activityDorsolateral prefrontal cortex activityHuman functional neuroimaging studiesFunctional magnetic resonance imagingPrefrontal cortex activityFunctional neuroimaging studiesCognitive reappraisalCognitive controlEmotion regulationCognitive processingCognitive processesCognitive strategiesEmotional experienceDLPFC functionNeuroimaging studiesDLPFC regionCortex activityEstradiol's rolePrefrontal cortexCortical systemsEmotionsAdolescent girlsActive attempts
2018
Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders
Lippard ETC, Johnston JAY, Spencer L, Quatrano S, Fan S, Sankar A, Weathers J, Pittman B, Oquendo MA, Blumberg HP. Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders. Journal Of Affective Disorders 2018, 245: 1139-1148. PMID: 30699858, PMCID: PMC6487887, DOI: 10.1016/j.jad.2018.11.097.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnisotropyBipolar DisorderCross-Sectional StudiesDepressive Disorder, MajorDiffusion Tensor ImagingFemaleFrontal LobeGray MatterGyrus CinguliHumansInternal CapsuleMagnetic Resonance ImagingMaleMood DisordersPrefrontal CortexSuicidal IdeationSuicide, AttemptedWhite MatterYoung AdultConceptsMood disordersGray matter volumeLongitudinal structural changesSuicide-related behaviorsFuture suicide attemptsFractional anisotropyWhite matter structuresMatter volumeWhite matterSuicide attemptsHigh-resolution structural magnetic resonance imagingYoung adultsWhite matter fractional anisotropyMajor risk factorStructural magnetic resonance imagingCross-sectional studyFrontal white matterPrefrontal gray matter volumeMatter structuresMagnetic resonance imagingDiffusion tensor imagingInternal capsuleRisk factorsAnterior limbPrevention strategiesGray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders
Fan S, Lippard ETC, Sankar A, Wallace A, Johnston JAY, Wang F, Pittman B, Spencer L, Oquendo MA, Blumberg HP. Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders. Journal Of Affective Disorders 2018, 245: 1089-1097. PMID: 30699851, PMCID: PMC6903411, DOI: 10.1016/j.jad.2018.11.095.Peer-Reviewed Original ResearchConceptsMajor depressive disorderYoung adult suicide attemptersNon-suicide attemptersAdult suicide attemptersBipolar disorderSuicide attemptersFractional anisotropyDepressive disorderGM volumePrevention strategiesBrain circuitryYoung adultsBrain circuitry abnormalitiesAdolescents/young adultsWhite matter fractional anisotropyEarly prevention strategiesAdolescence/young adulthoodMagnetic resonance scanningWhite matter alterationsGray matter volumeSuicide prevention strategiesPrior suicide attemptsWM fractional anisotropyWhole-brain analysisWhite matter differences
2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2016
Effects of ANK3 variation on gray and white matter in bipolar disorder
Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Effects of ANK3 variation on gray and white matter in bipolar disorder. Molecular Psychiatry 2016, 22: 1345-1351. PMID: 27240527, PMCID: PMC5133179, DOI: 10.1038/mp.2016.76.Peer-Reviewed Original Research
2015
Anterior Cortical Development During Adolescence in Bipolar Disorder
Najt P, Wang F, Spencer L, Johnston JA, Lippard E, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder. Biological Psychiatry 2015, 79: 303-310. PMID: 26033826, PMCID: PMC4595154, DOI: 10.1016/j.biopsych.2015.03.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderCase-Control StudiesEmotionsFemaleGray MatterHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNeuroimagingPrefrontal CortexWhite MatterYoung AdultConceptsWhite matter expansionBipolar disorderWhite matterAnterior cortexHealthy adolescentsHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansWhite matter increasesResonance imaging scansGray matter decreasesDorsolateral prefrontal cortexMatter expansionHealthy groupImaging scansCortical volumeFrontal cortexNeurodevelopmental abnormalitiesCortical developmentAnterior paralimbicNeurodevelopmental modelLongitudinal neuroimagingPrefrontal cortexCortexLongitudinal studyAdolescents
2011
Corticostriatal-Limbic Gray Matter Morphology in Adolescents With Self-reported Exposure to Childhood Maltreatment
Edmiston EE, Wang F, Mazure CM, Guiney J, Sinha R, Mayes LC, Blumberg HP. Corticostriatal-Limbic Gray Matter Morphology in Adolescents With Self-reported Exposure to Childhood Maltreatment. JAMA Pediatrics 2011, 165: 1069-1077. PMID: 22147775, PMCID: PMC3607102, DOI: 10.1001/archpediatrics.2011.565.Peer-Reviewed Original ResearchOlfactocentric paralimbic cortex morphology in adolescents with bipolar disorder
Wang F, Kalmar JH, Womer FY, Edmiston EE, Chepenik LG, Chen R, Spencer L, Blumberg HP. Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder. Brain 2011, 134: 2005-2012. PMID: 21666263, PMCID: PMC3122371, DOI: 10.1093/brain/awr124.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrain MappingFemaleHumansImage Processing, Computer-AssistedLimbic SystemMagnetic Resonance ImagingMaleNeural PathwaysPrefrontal CortexYoung AdultConceptsParalimbic corticesBipolar disorderHigh-resolution structural magnetic resonanceGray matter volume differencesVoxel-based morphometry analysisHealthy comparison adolescentsStructural magnetic resonanceSmall volume correctionSuperior temporal gyrusBipolar disorder pathologyNeurovegetative functionsBipolar disorder phenotypeTemporopolar cortexSignificant volume decreaseParalimbic regionsCortex morphologyTemporal gyrusCortexDisordersMorphometry analysisDisorder phenotypesInferior prefrontalCortex structureDisorder pathologyAdolescents
2009
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston E, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder. Biological Psychiatry 2009, 66: 516-521. PMID: 19427632, PMCID: PMC2830492, DOI: 10.1016/j.biopsych.2009.03.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaBipolar DisorderDiffusion Magnetic Resonance ImagingFacial ExpressionFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleNeural PathwaysTemporal LobeConceptsPerigenual anterior cingulate cortexHealthy comparison subjectsBipolar disorderFunctional magnetic resonance imagingDiffusion tensor imagingFunctional connectivityWhite matterFractional anisotropyHC groupPerigenual anterior cingulateAnterior cingulate cortexMagnetic resonance imagingGray matter structuresRegional fractional anisotropyWhite matter connectivityEmotional processingFunctional connectivity measuresSignificant positive associationBD groupComparison subjectsAnterior cingulateCingulate cortexResonance imagingSignificant associationBrain regions
2006
Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug TherapyFemaleHumansMagnetic Resonance ImagingMalePeriodicityPrefrontal CortexConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline
2003
Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder
Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.Peer-Reviewed Original ResearchConceptsHippocampal volumeMedial temporal lobe structuresTemporal lobe structuresBipolar disorderIllness featuresVeterans Affairs Medical CenterLobe structuresRepeated-measures statistical analysisCourse of illnessTotal brain volumeAmygdala volume reductionsBD type IAnatomic magnetic resonanceHealthy comparison subjectsPaucity of dataVolume reductionSignificant volume reductionVolumetric abnormalitiesNeurodegenerative changesIllness durationOutpatient treatmentUniversity HospitalGreater effect sizeMedical CenterHippocampal region