2024
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Sajatovic M, Rej S, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Beunders A, Blumberg H, Briggs F, Dols A, Forester B, Forlenza O, Gildengers A, Jimenez E, Klaus F, Lafer B, Mulsant B, Mwangi B, Nunes P, Olagunju A, Oluwaniyi S, Orhan M, Patrick R, Radua J, Rajji T, Sarna K, Schouws S, Simhandl C, Sekhon H, Soares J, Sutherland A, Teixeira A, Tsai S, Vidal‐Rubio S, Vieta E, Yala J, Eyler L. Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project. International Journal Of Geriatric Psychiatry 2024, 39: e6057. PMID: 38511929, DOI: 10.1002/gps.6057.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar Disorder DatabaseSomatic burdenBipolar disorderGAGE-BDAssociated with worse functionSymptom severityBD symptomsAssociated with depression severityOlder-age bipolar disorderGlobal Aging & Geriatric ExperimentsManic symptom severityAssociated with poorer functioningGeriatric experiencesAssociation of depressionBipolar symptomsSevere maniaDepression severityDepressive symptomsLow functioningSomatic conditionsPoor functionWorse functionArchival datasetWave 2Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Chen P, Sajatovic M, Briggs F, Mulsant B, Dols A, Gildengers A, Yala J, Beunders A, Blumberg H, Rej S, Forlenza O, Jimenez E, Schouws S, Orhan M, Sutherland A, Vieta E, Tsai S, Sarna K, Eyler L, Investigators T. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project. International Journal Of Geriatric Psychiatry 2024, 39: e6073. PMID: 38393311, DOI: 10.1002/gps.6073.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGAGE-BDSeverity of manic symptomsRates of suicidal thoughtsLower depressive symptomsComorbid physical conditionsClinical characteristics of peopleGeriatric experiencesManic symptomsClinical characteristicsDepressive symptomsSuicidal thoughtsCharacteristics of peoplePhysical burdenDisordersGlobal ageMedical burdenAge categoriesLogistic regression modelsMultinomial logistic regression modelCross-sectional analysisYounger groupMusculoskeletal domainsSymptoms
2023
Demographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project
Mallu A, Chan C, Eyler L, Dols A, Rej S, Blumberg H, Sarna K, Forester B, Patrick R, Forlenza O, Jimenez E, Vieta E, Schouws S, Sutherland A, Yala J, Briggs F, Sajatovic M. Demographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project. Bipolar Disorders 2023, 25: 637-647. PMID: 37798096, PMCID: PMC10843228, DOI: 10.1111/bdi.13381.Peer-Reviewed Original ResearchEssential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group
Lavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group. Bipolar Disorders 2023, 25: 554-563. PMID: 36843436, DOI: 10.1111/bdi.13312.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGeneral medical comorbidityGeriatric mental healthSubgroup of patientsInternational data collectionSubjective cognitive functionMedical comorbiditiesCurrent medicationsPsychiatric comorbidityFamily historyDelphi consensusPsychotic symptomsBD diagnosisClinical practiceSystematic reviewCognitive functionCore symptomsMental healthGlobal AGEingComorbiditiesDisordersSymptomsInitial recommendationsData collection
2022
Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project
Beunders A, Klaus F, Kok A, Schouws S, Kupka R, Blumberg H, Briggs F, Eyler L, Forester B, Forlenza O, Gildengers A, Jimenez E, Mulsant B, Patrick R, Rej S, Sajatovic M, Sarna K, Sutherland A, Yala J, Vieta E, Villa L, Korten N, Dols A. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project. Bipolar Disorders 2022, 25: 43-55. PMID: 36377516, PMCID: PMC10265276, DOI: 10.1111/bdi.13271.Peer-Reviewed Original ResearchConceptsBD II patientsStudy cohortBD subtypesSomatic burdenMultivariable analysisGeneral functioningBD-IIGlobal AGEingBD-I patientsCross-sectional analysisClinical factorsClinical differencesSevere depressionPsychiatric hospitalizationBipolar ICognitive impairmentLate onsetPatientsOlder ageDiagnostic definitionSubtypesGeneralized linear mixed modelCohortLinear mixed modelsRandom interceptDemographic and clinical characteristics of lithium‐treated older adults with bipolar disorder
Forlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder. Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.Peer-Reviewed Original ResearchConceptsLithium usersBipolar disorderClinical characteristicsOlder adultsDepression Rating ScaleCross-sectional analysisGlobal cognitive stateCardiovascular comorbiditiesCross-sectional approachClinical profileMood stabilizersLithium therapySevere depressionPsychiatric diagnosisRating ScaleCurrent prescriptionGlobal AGEingDisordersRapid cyclingAdultsRelevant differencesSafety concernsLower scoresCurrent useMethodological limitationsComparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning
Orhan M, Millett C, Klaus F, Blumberg HP, Briggs F, Chung KH, Korten N, McManus K, van Oppen P, Patrick RE, Sarna K, Sutherland A, Tsai SY, Villa LM, Yala J, Sajatovic M, Burdick KE, Eyler L, Dols A, consortium T. Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning. Journal Of Affective Disorders 2022, 314: 44-49. PMID: 35803392, DOI: 10.1016/j.jad.2022.06.074.Peer-Reviewed Original ResearchDemographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).
Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderFirst-generation antipsychoticsAntipsychotic drugsBipolar disorderPsychiatric hospitalizationMean age 63.2 yearsGlobal AGEingClinical characteristicsFrequent hospitalizationsClinical variablesSevere illnessTreatment statusGreater burdenHospitalizationDisorder databaseOlder adultsCross-sectional dataLongitudinal outcomesDisordersPatientsGeneralized mixed modelMultivariate model resultsInternational studiesDrugsObservational analysisSymptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD)
Eyler LT, Briggs FBS, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, Forester BP, Patrick RE, Forlenza OV, Gildengers A, Jimenez E, Vieta E, Mulsant BH, Schouws S, Paans NPG, Strejilevich S, Sutherland A, Tsai S, Sajatovic M. Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). American Journal Of Geriatric Psychiatry 2022, 30: 1096-1107. PMID: 35637088, PMCID: PMC10280310, DOI: 10.1016/j.jagp.2022.03.007.Peer-Reviewed Original ResearchCognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment
Montejo L, Torrent C, Jiménez E, Martínez‐Arán A, Blumberg HP, Burdick KE, Chen P, Dols A, Eyler LT, Forester BP, Gatchel JR, Gildengers A, Kessing LV, Miskowiak KW, Olagunju AT, Patrick RE, Schouws S, Radua J, del M. Bonnín C, Vieta E, Force I. Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment. Bipolar Disorders 2022, 24: 115-136. PMID: 34978124, DOI: 10.1111/bdi.13175.Peer-Reviewed Original ResearchConceptsComprehensive neuropsychological assessmentNeuropsychological assessmentCognitive domainsExecutive functionProcessing speedAttention/processing speedOlder adultsDetailed neuropsychological profileEuthymic older adultsComplete neuropsychological assessmentEffect sizeModerate effect sizeCognitive flexibilityVerbal learningMemory domainImmediate memoryVerbal fluencyCognitive performanceNeuropsychological profileOABD patientsSignificant effect sizeBipolar disorderCognitive functionOABDLarge significant effect sizes
2021
Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration
Almeida OP, Dols A, Blanken MAJT, Rej S, Blumberg HP, Villa L, Forester BP, Forlenza OV, Gildengers A, Vieta E, Jimenez E, Mulsant B, Schouws S, Tsai S, Korten NCM, Sutherland A, Briggs FBS, Flicker L, Eyler LT, Sajatovic M. Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration. American Journal Of Geriatric Psychiatry 2021, 30: 727-732. PMID: 34980553, DOI: 10.1016/j.jagp.2021.12.006.Peer-Reviewed Original ResearchConceptsBipolar disorderPhysical morbidityEndocrinological systemMore menMore womenEvidence of morbidityPhysical health burdenAdult bipolar disorderOutcomes of interestCross-sectional analysisEndocrinological diseasesHealth burdenOlder menMan studyMorbidityWomenGlobal AGEingMenDisordersDiseaseDisorder databaseYearsPrevalenceBipolar symptoms, somatic burden, and functioning in older‐age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project
Sajatovic M, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, Forester BP, Patrick RE, Forlenza OV, Gildengers A, Jimenez E, Vieta E, Mulsant B, Schouws S, Paans N, Strejilevich S, Sutherland A, Tsai S, Wilson B, Eyler LT. Bipolar symptoms, somatic burden, and functioning in older‐age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project. Bipolar Disorders 2021, 24: 195-206. PMID: 34314549, PMCID: PMC8792096, DOI: 10.1111/bdi.13119.Peer-Reviewed Original Research
2001
Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression
de Asis J, Stern E, Alexopoulos G, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig D. Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression. American Journal Of Psychiatry 2001, 158: 1321-1323. PMID: 11481171, DOI: 10.1176/appi.ajp.158.8.1321.Peer-Reviewed Original ResearchConceptsGeriatric depressionActivation deficitsComparison subjectsDorsal anterior cingulate gyrusPositron emission tomography scanEmission tomography scanDepressed geriatric patientsAnterior cingulate gyrusHealthy comparison subjectsElderly patientsGeriatric patientsFrontotemporal functionHippocampal dysfunctionTomography scanPrevalent disorderCingulate gyrusMemory dysfunctionWord generation taskPatientsMemory deficitsHippocampal activityActivation paradigmNeural substratesDepressionDysfunction
1990
General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degeneration
Gandy S, Grebb J, Rosen N, Albert K, Devinsky O, Blumberg H, Anderson N, Cedarbaum J, Porter R, Sedvall G, Posner J, Greengard P. General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degeneration. Annals Of Neurology 1990, 28: 829-833. PMID: 2285268, DOI: 10.1002/ana.410280616.Peer-Reviewed Original ResearchConceptsProtein kinase C substrate proteinProtein kinase substratesProtein phosphorylation systemsSubstrate proteinsKinase substratePhosphorylation systemBiochemical characterizationCell typesPhosphoproteinNeuronal cellsNeuronal diseasesNeuronal enrichmentGeneral assayUnique markerPotential insightsNeuronal populationsProteinNeurological diseasesCerebellar degenerationCellsAssaysEnrichmentAssay techniquesKdMarkers