2024
Neuromarkers in addiction: definitions, development strategies, and recent advances
Harp N, Wager T, Kober H. Neuromarkers in addiction: definitions, development strategies, and recent advances. Journal Of Neural Transmission 2024, 131: 509-523. PMID: 38630190, DOI: 10.1007/s00702-024-02766-2.Peer-Reviewed Original ResearchConceptsSubstance use disordersFeatures of substance use disordersResponse to treatmentNeurobiological basisAddiction neuroscienceIndividual treatment outcomesPsychiatric conditionsDetecting response to treatmentPsychological phenomenaNeuromarkersIndex riskSeverity of pathologyTreatment outcomesAbnormal processingAddictionPutative markerClinical practiceStable indicatorSevere pathologyAssess riskNeurosciencePathologyReview recent advancesDisordersTreatmentDevelopment and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareHumansMindfulnessMobile ApplicationsMotivationSubstance-Related DisordersConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2022
A neuromarker for drug and food craving distinguishes drug users from non-users
Koban L, Wager T, Kober H. A neuromarker for drug and food craving distinguishes drug users from non-users. Nature Neuroscience 2022, 26: 316-325. PMID: 36536243, DOI: 10.1038/s41593-022-01228-w.Peer-Reviewed Original ResearchConceptsFood cravingsFunctional magnetic resonance imaging studySelf-regulation strategiesCue-induced drugMagnetic resonance imaging studySelf-reported intensityResonance imaging studyFood cuesVentromedial prefrontalSubstance use disordersIntrospective accessMaladaptive behaviorsNeurobiological markersNeurobiological mechanismsParietal association areasCingulate cortexVentral striatumConvergent validityCore featuresCravingAssociation areasSubstance useNeuromarkersUse disordersClinical interventionsAssociation of Drug Cues and Craving With Drug Use and Relapse
Vafaie N, Kober H. Association of Drug Cues and Craving With Drug Use and Relapse. JAMA Psychiatry 2022, 79: 641-650. PMID: 35648415, PMCID: PMC9161117, DOI: 10.1001/jamapsychiatry.2022.1240.Peer-Reviewed Original Research
2020
Computational Models of Drug Use and Addiction: A Review
Mollick JA, Kober H. Computational Models of Drug Use and Addiction: A Review. Journal Of Psychopathology And Clinical Science 2020, 129: 544-555. PMID: 32757599, PMCID: PMC7416739, DOI: 10.1037/abn0000503.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBrainComputer SimulationHumansLearningModels, NeurologicalMotivationSubstance-Related DisordersConceptsBrain-based modelsBehavioral controlComputational modelGoal-directed systemAspects of addictionCurrent computational modelsExecutive control circuitPredictive coding approachSymptoms of addictionModel of learningComputational accountPrediction errorComputational theoryPrefrontal cortexDrug useBrain areasDorsal striatumAddictionDopamine systemEffects of drugsBasal gangliaHuman dataCoding approachesBroad categoriesMotivation
2010
Prefrontal–striatal pathway underlies cognitive regulation of craving
Kober H, Mende-Siedlecki P, Kross EF, Weber J, Mischel W, Hart CL, Ochsner KN. Prefrontal–striatal pathway underlies cognitive regulation of craving. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14811-14816. PMID: 20679212, PMCID: PMC2930456, DOI: 10.1073/pnas.1007779107.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersPrefrontal cortexVentral tegmental areaSubstance-dependent populationsMore effective treatmentsLong-term consumptionDorsolateral prefrontal cortex activityPrefrontal cortex activityCigarette smokersTegmental areaVentrolateral prefrontal cortexVentral striatum activityVentral striatal activitySubgenual cingulateEffective treatmentLateral prefrontal cortexStriatal activityVentral striatumCortex activityFunctional imagingPhysical healthStriatum activityNeural activityCortex