2019
Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol‐Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort
Meda SA, Narayanan B, Chorlian D, Meyers JL, Gelernter J, Hesselbrock V, Bauer L, Calhoun VD, Porjesz B, Pearlson G. Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol‐Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort. Alcohol Clinical And Experimental Research 2019, 43: 1462-1477. PMID: 31009096, DOI: 10.1111/acer.14063.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcoholismCase-Control StudiesCohort StudiesElectroencephalographyFemaleGenetic Association StudiesGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedMultigene FamilyNeuronsPhenotypePolymorphism, Single NucleotideSignal TransductionSubstance-Related DisordersWhite PeopleYoung AdultConceptsGenetic clustersSingle nucleotide polymorphism dataSignificant genotype-phenotype associationsNucleotide polymorphism dataLipid/cholesterol metabolismLinkage-based analysisGenotype-phenotype relationshipsGenotype-phenotype associationsGene clusterCell signalingPolymorphism dataMolecular mechanismsAlcoholism datasetGenomewide associationTop hitsGenetic componentNeuronal signalingGeneticsSignalingBiological componentsRelationship pairsCholesterol metabolismNeurogenesisSNP componentParallel independent component analysis
1991
Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAtrophyBrainCerebral VentriclesEthanolFollow-Up StudiesHumansMalePsychiatric Status Rating ScalesPsychotropic DrugsSubstance-Related DisordersTomography, X-Ray ComputedConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricular
1990
Demonstration of naturalistic methods for cocaine smoking by human volunteers
Foltin R, Fischman M, Nestadt G, Stromberger H, Cornell E, Pearlson G. Demonstration of naturalistic methods for cocaine smoking by human volunteers. Drug And Alcohol Dependence 1990, 26: 145-154. PMID: 2242715, DOI: 10.1016/0376-8716(90)90121-t.Peer-Reviewed Original ResearchConceptsVenous blood levelsClinical research unitBlood level curvesFirst doseSubsequent dosesBlood pressureDosing sessionsBlood levelsAcute toleranceCocaine smokingHeart rateDose sessionAscending limbBaseline levelsCardiovascular activityHuman volunteersSubjective effectsTransient increaseResearch volunteersDosesMale research volunteersCocaineVolunteersSubjectsLimb
1989
Cocaine-induced delirium versus delusional disorder
Pearlson G, Fischman M, Foltin R, Cornell E, Pedroso J. Cocaine-induced delirium versus delusional disorder. Biological Psychiatry 1989, 26: 847-848. PMID: 2590695, DOI: 10.1016/0006-3223(89)90125-x.Peer-Reviewed Original ResearchAdultCocaineDeliriumDelusionsDiagnosis, DifferentialHumansMalePsychoses, Substance-InducedSubstance-Related Disorders