2024
Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.Peer-Reviewed Original ResearchPosttraumatic stress disorderMedial prefrontal cortexStress disorderPosttraumatic stress disorder patientsPosttraumatic stress disorder diagnosisChronic psychiatric conditionImpact of psychiatric comorbiditiesComorbid MDDPrefrontal cortexDepressive disorderTraumatic stressorsPsychiatric conditionsMDDPsychiatric comorbiditiesNeurotransmitter abnormalitiesConcentrations of glutamateMetabolite abnormalitiesHealthy controlsDisordersPattern of abnormalitiesParticipantsGlutamateIn vivo protonMetabolic abnormalitiesDepression
1995
In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy
Novotny E, Avison M, Herschkowitz N, Petroff O, Prichard J, Seashore M, Rothman D. In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy. Pediatric Research 1995, 37: 244-249. PMID: 7731764, DOI: 10.1203/00006450-199502000-00020.Peer-Reviewed Original ResearchConceptsPhe concentrationsPlasma Phe concentrationsEfficacy of therapyCerebral concentrationsUntreated subjectsCerebral metabolitesNeurometabolic disorderControl studyPKU patientsPlasma PheMagnetic resonance spectroscopyMajor causePhenylketonuriaClinical magnetic resonance imaging systemNuclear magnetic resonance spectroscopyMagnetic resonance imaging systemHuman brainResonance imaging systemDisordersSubjectsImaging systemProton nuclear magnetic resonance spectroscopic studiesMagnetic resonance spectroscopic studiesResonance spectroscopyPHE signal