2024
Deficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acidsBrain energy metabolism: A roadmap for future research
Rae C, Baur J, Borges K, Dienel G, Díaz‐García C, Douglass S, Drew K, Duarte J, Duran J, Kann O, Kristian T, Lee‐Liu D, Lindquist B, McNay E, Robinson M, Rothman D, Rowlands B, Ryan T, Scafidi J, Scafidi S, Shuttleworth C, Swanson R, Uruk G, Vardjan N, Zorec R, McKenna M. Brain energy metabolism: A roadmap for future research. Journal Of Neurochemistry 2024, 168: 910-954. PMID: 38183680, PMCID: PMC11102343, DOI: 10.1111/jnc.16032.Peer-Reviewed Original Research
2021
Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles
Rothman D, De Feyter H, Mason G, de Graaf R, Hyder F, Behar K. Methods | 13C MRS Measurements of in Vivo Rates of the Glutamate/Glutamine and GABA/Glutamine Neurotransmitter Cycles. 2021, 688-700. DOI: 10.1016/b978-0-12-819460-7.00341-8.Chapters
2014
Chapter 4.2 Carbon (13C) MRS
Rothman D, De Feyter H. Chapter 4.2 Carbon (13C) MRS. 2014, 312-330. DOI: 10.1016/b978-0-12-401688-0.00023-9.ChaptersNeurotransmitter cyclingHigh neuronal activityHuman brain diseasesOnly noninvasive methodBrain metabolismGlutamate neurotransmissionNeuronal activityMRS studiesPsychiatric diseasesNeuronal functionBrain diseasesBrain functionClinical researchNeuroenergeticsNoninvasive methodDiseaseMRSMRS measurementsHuman researchBrain statesRecent findingsImportant new informationHumansMetabolic pathwaysNeurotransmission
1994
NMR studies of human brain function
Shulman R, Rothman D, Blamire A. NMR studies of human brain function. Trends In Biochemical Sciences 1994, 19: 522-526. PMID: 7846759, DOI: 10.1016/0968-0004(94)90050-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPositron emission tomographyUnstimulated subjectsResonance imagingEmission tomographyBrain functionHuman brain functionSensory stimulationVisual stimulationBrain activityHuman brain activityHuman brainStimulationMetabolic rateSignificant improvementMagnetic resonance spectroscopySingle subjectSubjectsEstablished method
1993
Nuclear magnetic resonance imaging and spectroscopy of human brain function.
Shulman R, Blamire A, Rothman D, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 3127-3133. PMID: 8475050, PMCID: PMC46253, DOI: 10.1073/pnas.90.8.3127.Peer-Reviewed Original ResearchConceptsRegional cerebral blood volumeMagnetic resonance imagingMR spectroscopyResonance imagingBrain functionHuman brain functionCerebral glutamate poolPositron emission tomography studyBrain glucose concentrationsEmission tomography studiesCerebral blood volumeBlood oxygenation levelVivo magnetic resonance imagingConcentration of lactateBrain metabolismMotor cortexCerebral vasculatureSubsequent glucose metabolismBlood flowGlucose metabolismBlood volumeFrontal lobeVisual cortexBrain tissueTomography study