2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased riskβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking memory deficitsWorking memory taskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDlPFCBehavior analysisCortexPyramidal cells
2023
Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives
Datta D. Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives. The Journals Of Gerontology Series A 2023, 78: 1523-1534. PMID: 37279946, PMCID: PMC10460555, DOI: 10.1093/gerona/glad134.Peer-Reviewed Original ResearchConceptsPrimate dorsolateral prefrontal cortexSporadic Alzheimer's diseaseAlzheimer's diseaseDorsolateral prefrontal cortexRhesus macaquesPrefrontal cortexSignificant risk factorsHuman Alzheimer's diseaseAspartic acid (NMDA) receptorsNonhuman primate modelNovel therapeutic strategiesCalcium-buffering proteinsPattern of pathologyInflammatory cascadeTau pathologyNeuropathological cascadeSynaptic dysfunctionRisk factorsPrimate modelNeurofibrillary tanglesAmyloid plaquesDendritic spinesTherapeutic strategiesGenetic predispositionAnimal models
2020
The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex
Arnsten AFT, Datta D, Wang M. The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex. Molecular Psychiatry 2020, 26: 3684-3700. PMID: 33319854, PMCID: PMC8203737, DOI: 10.1038/s41380-020-00973-3.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexCognitive disordersPrefrontal cortexPrimate dorsolateral prefrontal cortexHigher cortical circuitsPrimary visual cortexInternal calcium releaseRisk of schizophreniaAge-related lossLevels of calciumDendritic atrophyAmyloid pathologyCalcium binding proteinInflammatory insultCalcium overloadTau phosphorylationCortical circuitsDendritic spinesNeuronal firingCalcium channelsAssociation cortexSynaptic efficacyVisual cortexAlzheimer's diseaseSpecial molecular mechanismMapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits
Datta D, Enwright JF, Arion D, Paspalas CD, Morozov YM, Lewis DA, Arnsten AFT. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers In Neuroanatomy 2020, 14: 578483. PMID: 33328902, PMCID: PMC7714912, DOI: 10.3389/fnana.2020.578483.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexSmooth endoplasmic reticulumPrefrontal cortexHuman dlPFCPrimate dorsolateral prefrontal cortexHuman post-mortem tissueInternal calcium releasePrimate association corticesPost-mortem tissueMacaque dorsolateral prefrontal cortexPrimate dlPFCAxospinous synapsesPV interneuronsGlutamatergic connectionsGlutamatergic synapsesPyramidal cellsAxon terminalsTransmitter releaseTau phosphorylationDendritic spinesPDE4 isozymesAssociation cortexLayer IIICAMP actionPostsynaptic labelingLaminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex
Glausier J, Datta D, Fish K, Chung D, Melchitzky D, Lewis D. Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex. Neuroscience 2020, 452: 181-191. PMID: 33212224, PMCID: PMC7770119, DOI: 10.1016/j.neuroscience.2020.10.022.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsDorsolateral prefrontal cortexHuman dorsolateral prefrontal cortexPyramidal neuronsDendritic spinesDensity of spinesMonkey dorsolateral prefrontal cortexPrefrontal cortexPrimate dorsolateral prefrontal cortexDeep cortical layersPyramidal neuron activitySpecific neural circuitsGABAergic inputsGlutamatergic inputsGABAergic interneuronsGlutamatergic synapsesLaminar differencesCore cognitive functionNeuron activitySynaptic informationNeuron synapseCortical layersInterneuronsRecurrent excitationCognitive function
2014
Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex
Gonzalez-Burgos G, Miyamae T, Pafundo D, Yoshino H, Rotaru D, Hoftman G, Datta D, Zhang Y, Hammond M, Sampson A, Fish K, Ermentrout G, Lewis D. Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex. Cerebral Cortex 2014, 25: 4076-4093. PMID: 24904071, PMCID: PMC4626828, DOI: 10.1093/cercor/bhu122.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAge FactorsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornCalcium Channel BlockersExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFemaleGABA AntagonistsGamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsLysineMacaca mulattaModels, NeurologicalNeuronsOmega-Agatoxin IVAPrefrontal CortexPyridazinesSynapsesConceptsDorsolateral prefrontal cortexSynapse densityPyramidal cellsPrepubertal ageParvalbumin-positive GABA neuronsMonkey dorsolateral prefrontal cortexPrefrontal cortexPrimate dorsolateral prefrontal cortexInhibitory synapse densityInhibitory postsynaptic currentsAdult macaque monkeysCortical network activityDevelopment of GABAYoung adult ageDlPFC circuitsGamma frequency oscillationsGABA neuronsGABA synapsesInhibitory synaptogenesisPostsynaptic currentsPeripubertal periodSynaptic appositionsGamma band powerMacaque monkeysFunctional maturation