Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchConceptsTaste responsesNicotine concentrationsNicotine exposureNicotine withdrawalNicotine effectsAdolescent ratsChronic exposureOral nicotine exposureTaste reactivityAversive tasteChronic nicotine exposureDevelopment of toleranceLow nicotine concentrationsE-cigarette useE-cigarette flavoringsHigher nicotine concentrationsNicotine abstinenceNicotine useNaïve animalsChronic effectsNicotineRatsAversive responsesDifferent nicotine concentrationsWithdrawalGenotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice
Akinola LS, Rahman Y, Ondo O, Gonzales J, Bagdas D, Jackson A, Davidson-Wert N, Damaj MI. Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice. Frontiers In Neuroscience 2022, 16: 905330. PMID: 35769694, PMCID: PMC9234577, DOI: 10.3389/fnins.2022.905330.Peer-Reviewed Original ResearchOral nicotine consumptionEffect of mentholD2J miceMenthol effectsNicotine consumptionΑ7 nAChRsDifferential effectsTwo-bottle choiceTAAR1 geneOral aversionC57BL/6J miceNicotine rewardSystemic administrationNicotine intakeDBA/2J miceB6J micePharmacological responseNicotine addictionGenotype-specific mechanismsNicotine concentrationsMiceMouse strainsBasal preferenceGenetic factorsNicotine