Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome
Cadeddu R, Braccagni G, Branca C, van Luik E, Pittenger C, Thomsen M, Bortolato M. Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome. British Journal Of Pharmacology 2024, 181: 3064-3081. PMID: 38689378, DOI: 10.1111/bph.16392.Peer-Reviewed Original ResearchPositive allosteric modulatorsD1CT-7 miceTourette syndromeMouse model of TSStriatal cholinergic interneuronsTic-like behavioursC-Fos levelsModel of TSActivate c-fosM4 muscarinic receptorsMuscarinic receptorsStriatal acetylcholineMouse modelStriatal expressionTic-likeStriatal levelsCholinergic interneuronsVU0467154Current pharmacotherapyXanomelineReceptor agonistsAllosteric modulatorsC-fosReceptor antagonistStriatum