2024
Mapping the Depressed Brain Under Stress Using Multimodal Neuroimaging
Akiki T, Abdallah C. Mapping the Depressed Brain Under Stress Using Multimodal Neuroimaging. American Journal Of Psychiatry 2024, 181: 578-580. PMID: 38946274, DOI: 10.1176/appi.ajp.20240400.Peer-Reviewed Original ResearchBrainBrain MappingDepressive Disorder, MajorHumansMagnetic Resonance ImagingMultimodal ImagingNeuroimagingStress, PsychologicalUltrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder
Tamman A, Abdallah C. Ultrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder. Biological Psychiatry 2024, 95: 385-386. PMID: 38325915, DOI: 10.1016/j.biopsych.2023.12.022.Peer-Reviewed Original ResearchMeSH KeywordsBrainDepressive Disorder, MajorHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProton Magnetic Resonance Spectroscopy
2020
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsDepressive Disorder, MajorHumansKetamineMechanistic Target of Rapamycin Complex 1SirolimusTreatment OutcomeConceptsAntidepressant effectsKetamine administrationRapamycin pretreatmentMontgomery-Åsberg Depression Rating ScaleDouble-blind cross-over designBenefits of ketamineRobust antidepressant effectsKetamine's antidepressant effectsMajor depressive episodeDepression Rating ScaleCross-over designKetamine exertsOral rapamycinRemission rateDepressive episodePlacebo 2Ketamine 0.5Local blockadeDepressed patientsIntravenous administrationTreatment daysDepression relapseDepression severityKetamineRating Scale