2021
Atypical Dynamic Functional Network Connectivity State Engagement during Social–Emotional Processing in Schizophrenia and Autism
Hyatt CJ, Wexler BE, Pittman B, Nicholson A, Pearlson GD, Corbera S, Bell MD, Pelphrey K, Calhoun VD, Assaf M. Atypical Dynamic Functional Network Connectivity State Engagement during Social–Emotional Processing in Schizophrenia and Autism. Cerebral Cortex 2021, 32: 3406-3422. PMID: 34875687, PMCID: PMC9376868, DOI: 10.1093/cercor/bhab423.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial-emotional processingDFNC statesDifferent neural processingFunction of emotionFunctional connectivity patternsHappy videosSad videosNeutral contentNeural processingTask scoresSpectrum disorderDifferential engagementDFNC measuresMore timeYoung adultsConnectivity patternsState engagementEmotionsSchizophreniaIndependent component analysisEngagementProcessingSignificant relationshipAlexithymia
2013
Emotion self-regulation and empathy depend upon longer stimulus exposure
Ikezawa S, Corbera S, Wexler BE. Emotion self-regulation and empathy depend upon longer stimulus exposure. Social Cognitive And Affective Neuroscience 2013, 9: 1561-1568. PMID: 24064924, PMCID: PMC4187273, DOI: 10.1093/scan/nst148.Peer-Reviewed Original ResearchConceptsLate positive potentialSelf-regulatory processesEvent-related potentialsEmpathic responsesLate event-related potentialsThreat-related stimuliPain-related stimuliLonger stimulus exposuresLate ERP componentsPictures of handsStimulus exposure durationAttentional modulationERP responsesERP componentsNeural basisBrain processingStimulus exposureTask conditionsStimulus presentationNeutral situationsProcessing existClinical populationsStimulus durationExposure durationJudgment condition
2012
Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2004
Neural Circuits Underlying Emotional Distress in Humans
SINHA R, LACADIE C, SKUDLARSKI P, WEXLER BE. Neural Circuits Underlying Emotional Distress in Humans. Annals Of The New York Academy Of Sciences 2004, 1032: 254-257. PMID: 15677422, DOI: 10.1196/annals.1314.032.Peer-Reviewed Original ResearchConceptsEmotional distressHealthy volunteersFunctional magnetic resonance imaging (fMRI) techniquesStressful life eventsEmotional stressPosterior cingulate regionsPrefrontal cortical circuitsSubstance use disordersStress processingBrain activationBrain correlatesImagery trialsMedial prefrontalAnterior cingulateLife eventsCingulate regionsMagnetic resonance imaging techniquesParahippocampal gyrusCortical circuitsUse disordersHealthy individualsDistressNeural circuitsSignificant activationClinical samplesFunctional MRI changes before and after onset of reported emotions
Prohovnik I, Skudlarski P, Fulbright RK, Gore JC, Wexler BE. Functional MRI changes before and after onset of reported emotions. Psychiatry Research 2004, 132: 239-250. PMID: 15664795, DOI: 10.1016/j.pscychresns.2004.03.005.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEmotional responsesConscious emotional experienceBrain regionsBrain-imaging studiesSubjective emotional responsesNegative emotional responsesFace social interactionsSuperior temporal gyrusMiddle frontal gyrusEmotion-related behaviorsDistinctive brain regionsMultiple brain regionsCognitive tasksEvoked emotionHealthy young adultsNeural correlatesSad conditionEmotional experienceFrontal gyrusReported onsetEmotional stimulationTemporal gyrusSensory regionsSocial interaction
2003
Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, Gore JC, Olson IR, McGlashan TH, Wexler BE. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry 2003, 54: 1284-1293. PMID: 14643096, DOI: 10.1016/s0006-3223(03)00636-x.Peer-Reviewed Original ResearchConceptsNormal control subjectsBorderline personality disorderControl subjectsBorderline patientsAmygdala hyperreactivityBPD patientsPersonality disorderEmotional dysregulationDisorders of moodFunctional magnetic resonance imagingMagnetic resonance imagingClinical research teamPatientsResonance imagingPsychiatry departmentDSM-IVAmygdala reactivityAmygdala activationDisordersNeural responsesHyperreactivityDysregulationActivation levelsSubjectsRobust differencesGambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study
Potenza MN, Steinberg MA, Skudlarski P, Fulbright RK, Lacadie CM, Wilber MK, Rounsaville BJ, Gore JC, Wexler BE. Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study. JAMA Psychiatry 2003, 60: 828-836. PMID: 12912766, DOI: 10.1001/archpsyc.60.8.828.Peer-Reviewed Original ResearchConceptsPathological gamblingGambling urgesBrain activityEchoplanar functional magnetic resonance imagingPG subjectsFunctional magnetic resonance imaging studyGroup differencesFunctional magnetic resonance imagingVentral anterior cingulateRegional brain activityBrain activity changesGambling cuesMagnetic resonance imaging studyResonance imaging studyNeural correlatesMotivational responsesBrain mechanismsGambling stimuliImpulse regulationTemporal epochsSad contentGambling behaviorOrbitofrontal cortexLimbic brain structuresAnterior cingulate
2002
Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces
Bruder GE, Stewart JW, McGrath PJ, Julie G, Wexler BE, Quitkin FM. Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces. Journal Of Psychopathology And Clinical Science 2002, 111: 446-454. PMID: 12150420, DOI: 10.1037/0021-843x.111.3.446.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAtypical depressionTypical depressionRight hemispheric dominanceNeurophysiologic studiesDepressive disorderHealthy controlsVegetative symptomsPatientsDistinct subtypesDiagnostic distinctionHemisphere biasHemispheric dominanceDepressionDysthymiaRight hemisphere biasFurther evidenceFace testHemispatial biasPhysical anhedoniaSymptomsSubtypesControlReplication of a premenstrual decrease in right-ear advantage on language-related dichotic listening tests of cerebral laterality
Alexander GM, Altemus M, Peterson BS, Wexler BE. Replication of a premenstrual decrease in right-ear advantage on language-related dichotic listening tests of cerebral laterality. Neuropsychologia 2002, 40: 1293-1299. PMID: 11931932, DOI: 10.1016/s0028-3932(01)00220-2.Peer-Reviewed Original ResearchConceptsRight ear advantageNeutral wordsOverall right ear advantageNegative affective toneWord-word pairsDichotic word taskPremenstrual weekDichotic listening testPerceptual asymmetryWord taskAffective valenceTask demandsAffective toneHemispheric advantageTask performanceREA scoresPositive wordCerebral lateralityTest sessionsFunctional asymmetryListening testsWordsIdentical measuresSex differencesStimuli
2001
Functional Magnetic Resonance Imaging of Cocaine Craving
Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. Functional Magnetic Resonance Imaging of Cocaine Craving. American Journal Of Psychiatry 2001, 158: 86-95. PMID: 11136638, DOI: 10.1176/appi.ajp.158.1.86.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHealthy subjectsCocaine-dependent subjectsMagnetic resonance imagingResonance imagingCocaine addictsReported onsetBrain activationBrain activityRegional brain activationFrontal lobe activationAnterior cingulate activationNeurobiology of addictionCocaine cravingAnterior cingulatePatientsFrontal lobePhysiologic linkSensory areasComparison of groupsDrug cravingDysphoric statesLess activationGeneral abnormalityCingulate activation
1994
Decreased perceptual sensitivity to emotion-evoking stimuli in depression
Wexler B, Levenson L, Warrenburg S, Price L. Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psychiatry Research 1994, 51: 127-138. PMID: 8022947, DOI: 10.1016/0165-1781(94)90032-9.Peer-Reviewed Original ResearchConceptsFacial displaysOwn faceNegative emotion-related wordsEmotion-evoking stimuliEmotion-related wordsDichotic listening paradigmEmotion-related stimuliNegative facial displaysNormal cognitive processingNeutral wordsAutomatic mimicryCognitive processingPerceptual sensitivityFacial mimicryNegative wordsEmotional responsesDichotic testsSelective perceptionDepressed patientsStimuliWordsHealthy controlsEmotionsFaceSuch measures
1992
EEG and EMG responses to emotion-evoking stimuli processed without conscious awareness
Wexler B, Warrenburg S, Schwartz G, Janer L. EEG and EMG responses to emotion-evoking stimuli processed without conscious awareness. Neuropsychologia 1992, 30: 1065-1079. PMID: 1484602, DOI: 10.1016/0028-3932(92)90099-8.Peer-Reviewed Original ResearchConceptsConscious awarenessGreater right hemisphere activityEmotion-evoking stimuliEmotion-specific responsesRight hemisphere activityEEG alpha activityRight frontal regionNeutral wordsConscious processingStimulus pairsAuditory perceptsHemisphere activityPositive feelingsFrontal regionsWordsAlpha activityStimuliEEGPerceptAwarenessCorrugatorFeelingsThoughtProcessingEMG responses
1991
Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder
Wexler B, Goodman W. Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder. Biological Psychiatry 1991, 29: 900-908. PMID: 2049488, DOI: 10.1016/0006-3223(91)90056-r.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEmotion-related wordsNeutral wordsCerebral lateralityLower right-ear advantagesPerception of emotionPositive emotional valenceRight ear advantageDichotic listening testEmotional valenceStimulus pairsOCD patientsListening testsWordsHealthy controlsDepressed patientsSerotonin reuptake inhibitorsLateralityEmotionsDisordersReuptake inhibitorsSevere illnessTreatment responseValencePatients
1989
Changes in perceptual asymmetry with the menstrual cycle
Altemus M, Wexler B, Boulis N. Changes in perceptual asymmetry with the menstrual cycle. Neuropsychologia 1989, 27: 233-240. PMID: 2927632, DOI: 10.1016/0028-3932(89)90174-7.Peer-Reviewed Original ResearchConceptsRight ear advantageRepressive personality stylePerceptual asymmetryPersonality stylesUsual right ear advantageLanguage-related stimuliDichotic listening testPsychological featuresNeuropsychological findingsEar advantagePostmenstrual phaseMenstrual cycleListening testsStyleStimuliAsymmetryFindings
1986
A Model of Brain Function: Its Implications for Psychiatric Research
Wexler B. A Model of Brain Function: Its Implications for Psychiatric Research. The British Journal Of Psychiatry 1986, 148: 357-362. PMID: 3730703, DOI: 10.1192/bjp.148.4.357.Peer-Reviewed Original ResearchEffects of emotion on perceptual asymmetry: Interactions with personality
Wexler B, Schwartz G, Warrenburg S, Servis M, Tarlatzis I. Effects of emotion on perceptual asymmetry: Interactions with personality. Neuropsychologia 1986, 24: 699-710. PMID: 3785657, DOI: 10.1016/0028-3932(86)90009-6.Peer-Reviewed Original ResearchConceptsPerceptual asymmetryAnxious subjectsEffects of emotionHigh-anxious subjectsLow-anxious subjectsLeft-hemisphere functionDichotic word testDichotic listening testWord TestEmotional qualityLeft hemisphereEmotionsPersonality characteristicsInformation processingPersonality groupsBrain statesListening testsNeutral testWordsHemispherePersonalitySubjectsProcessingTestAsymmetry