2023
Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia
Peterson B, Kaur T, Sawardekar S, Colibazzi T, Hao X, Wexler B, Bansal R. Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia. Frontiers In Cellular Neuroscience 2023, 17: 1126577. PMID: 36909281, PMCID: PMC9996667, DOI: 10.3389/fncel.2023.1126577.Peer-Reviewed Original ResearchClinical symptomsHealthy controlsAnatomical abnormalitiesMemory deficitsPathogenesis of schizophreniaSeverity of symptomsEffects of schizophreniaHippocampal bodyAmygdala morphologyLimbic regionsPatientsHippocampusInward deformationCognitive deficitsBrain structuresHC participantsSchizophreniaAmygdalaSymptomsMemory performanceContinuum of severityAnatomical MRIPrimary disturbanceMemory scoresAbnormalities
2021
Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder
Corbera S, Wexler BE, Bell MD, Pearlson G, Mayer S, Pittman B, Belamkar V, Assaf M. Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder. Psychiatry Research 2021, 303: 114087. PMID: 34246005, PMCID: PMC8373814, DOI: 10.1016/j.psychres.2021.114087.Peer-Reviewed Original ResearchConceptsSocial functioningCognitive empathyNegative symptomsAutism spectrum disorderWorse social functioningGreater negative symptomsHigher social functioningAffective empathySocial cognitionPersonal distressCommunication deficitsSpectrum disorderFunctioning impairmentQuality of lifeEmpathy scoresASDHigher QOLIQHealthy controlsEmpathySymptom severityDeficitsSchizophreniaWorse QOLFunctioning
2019
Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification
Rabany L, Brocke S, Calhoun VD, Pittman B, Corbera S, Wexler BE, Bell MD, Pelphrey K, Pearlson GD, Assaf M. Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification. NeuroImage Clinical 2019, 24: 101966. PMID: 31401405, PMCID: PMC6700449, DOI: 10.1016/j.nicl.2019.101966.Peer-Reviewed Original ResearchEffects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2018
Measuring theory of mind in schizophrenia research: Cross-cultural validation
Lee HS, Corbera S, Poltorak A, Park K, Assaf M, Bell MD, Wexler BE, Cho YI, Jung S, Brocke S, Choi KH. Measuring theory of mind in schizophrenia research: Cross-cultural validation. Schizophrenia Research 2018, 201: 187-195. PMID: 29958750, DOI: 10.1016/j.schres.2018.06.022.Peer-Reviewed Original ResearchConceptsSocial Attribution Task-Multiple ChoiceTheory of mindSocial cognition measuresSocial cognition tasksSocial cognitive impairmentsSchizophrenia researchInternal consistencyConvergent/divergent validityConfirmatory factor analysisGood internal consistencyOne-factor modelCognition measuresCognition tasksIndividual differencesGood model fitCross-cultural validationMental statesMeasurement invarianceDivergent validityDiscriminant validityToMFactor structureHealthy controlsCognitive impairmentDiverse languages
2017
SU26. Measuring Implicit Theory of Mind in Schizophrenia Research: Cross-Cultural Validation
Lee H, Poltorak A, Park K, Assaf M, Bell M, Wexler B, Choi K, Corbera S, Lee H. SU26. Measuring Implicit Theory of Mind in Schizophrenia Research: Cross-Cultural Validation. Schizophrenia Bulletin 2017, 43: s170-s170. PMCID: PMC5476051, DOI: 10.1093/schbul/sbx024.024.Peer-Reviewed Original ResearchSocial cognition tasksConfirmatory factor analysisCognition tasksImplicit theoriesSocial Attribution Task-Multiple ChoiceSocial cognition measuresSocial cognitive impairmentsEarly social developmentSchizophrenia researchFactor analysisSeries of ANOVAsPsychiatric symptomsGood internal consistencyCognition measuresGood model fitConscious awarenessInternal consistency coefficientsPremorbid IQCross-cultural validationMental statesFactor structureHealthy controlsValid measureLanguage differencesExtraneous variables
2014
Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuliNeural activation abnormalities during self-referential processing in schizophrenia: An fMRI study
Liu J, Corbera S, Wexler BE. Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study. Psychiatry Research 2014, 222: 165-171. PMID: 24795158, DOI: 10.1016/j.pscychresns.2014.04.003.Peer-Reviewed Original ResearchConceptsActivation abnormalitiesHealthy controlsCortical midline structuresMidline structuresBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFunctional magnetic resonanceGeneral neuropathologySchizophrenia altersTemporal gyrusPatientsAbnormalitiesSchizophreniaActivation paradigmGreater signal increaseGroup differencesFMRI studyPosterior regionSelf-referential processingMothersMagnetic resonanceDependent signalsNeuropathologyControlGyrus
2013
Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptomsDoes baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2004
Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophrenia Research 2004, 68: 137-147. PMID: 15099598, DOI: 10.1016/s0920-9964(03)00156-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory PerceptionCerebral CortexCognition DisordersDichotic Listening TestsDominance, CerebralFemaleFunctional LateralityHumansMaleMemory DisordersMental RecallNeuropsychological TestsPaired-Associate LearningPitch DiscriminationPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyVerbal LearningWechsler ScalesConceptsVerbal memory deficitsMemory deficitsVerbal memoryWechsler Memory Scale-RevisedNonverbal cognitive functionsDifferent cognitive deficitsSerial position effectsVerbal materialVisual memoryNonverbal testsAuditory perceptionGeneralized deficitSelective deficitDichotic wordsHemispheric dominanceCognitive deficitsCognitive functionMemoryMedication statusHealthy controlsDeficitsOverall poor performancePosition effectsPoor performancePosition test
2002
Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces
Bruder GE, Stewart JW, McGrath PJ, Julie G, Wexler BE, Quitkin FM. Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces. Journal Of Psychopathology And Clinical Science 2002, 111: 446-454. PMID: 12150420, DOI: 10.1037/0021-843x.111.3.446.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAtypical depressionTypical depressionRight hemispheric dominanceNeurophysiologic studiesDepressive disorderHealthy controlsVegetative symptomsPatientsDistinct subtypesDiagnostic distinctionHemisphere biasHemispheric dominanceDepressionDysthymiaRight hemisphere biasFurther evidenceFace testHemispatial biasPhysical anhedoniaSymptomsSubtypesControl
1997
Normal neurocognitive performance after extended practice in patients with schizophrenia
Wexler B, Hawkins K, Rounsaville B, Anderson M, Sernyak M, Green M. Normal neurocognitive performance after extended practice in patients with schizophrenia. Schizophrenia Research 1997, 26: 173-180. PMID: 9323348, DOI: 10.1016/s0920-9964(97)00053-4.Peer-Reviewed Original ResearchConceptsWeeks of practiceSpecific neurocognitive tasksNormal neurocognitive performancePerformance of patientsImplicit learningMemory taskNeurocognitive tasksNeurocognitive performanceExtended practiceSame taskMotor tasksNeurocognitive improvementDifficulty levelOngoing instructionPerformance declineBase payTaskSupranormal performanceSchizophreniaHealthy controlsMemoryLearningInstructionTrainingPerformance
1994
Decreased perceptual sensitivity to emotion-evoking stimuli in depression
Wexler B, Levenson L, Warrenburg S, Price L. Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psychiatry Research 1994, 51: 127-138. PMID: 8022947, DOI: 10.1016/0165-1781(94)90032-9.Peer-Reviewed Original ResearchConceptsFacial displaysOwn faceNegative emotion-related wordsEmotion-evoking stimuliEmotion-related wordsDichotic listening paradigmEmotion-related stimuliNegative facial displaysNormal cognitive processingNeutral wordsAutomatic mimicryCognitive processingPerceptual sensitivityFacial mimicryNegative wordsEmotional responsesDichotic testsSelective perceptionDepressed patientsStimuliWordsHealthy controlsEmotionsFaceSuch measures
1991
Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder
Wexler B, Goodman W. Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder. Biological Psychiatry 1991, 29: 900-908. PMID: 2049488, DOI: 10.1016/0006-3223(91)90056-r.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEmotion-related wordsNeutral wordsCerebral lateralityLower right-ear advantagesPerception of emotionPositive emotional valenceRight ear advantageDichotic listening testEmotional valenceStimulus pairsOCD patientsListening testsWordsHealthy controlsDepressed patientsSerotonin reuptake inhibitorsLateralityEmotionsDisordersReuptake inhibitorsSevere illnessTreatment responseValencePatientsCerebral laterality, symptoms, and diagnosis in psychotic patients
Wexler B, Giller E, Southwick S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biological Psychiatry 1991, 29: 103-116. PMID: 1995082, DOI: 10.1016/0006-3223(91)90039-o.Peer-Reviewed Original ResearchConceptsRight ear advantageLower right-ear advantagesManic patientsPositive symptomsNegative symptomsCerebral lateralitySubset of patientsDisease-related decreaseWord TestSchizoaffective patientsSymptomatic inpatientsDepressed patientsHealthy controlsSymptom remissionSchizophrenic patientsMood disturbancePatientsMore symptomsPsychotic patientsSymptomsDichotic word testLeft hemisphereEar advantageThought disorderSimilar changes