2024
Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA
Warner-Schmidt J, Stogniew M, Mandell B, Rowland R, Schmidt E, Kelmendi B. Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA. Frontiers In Neuroscience 2024, 18: 1353131. PMID: 38389788, PMCID: PMC10882719, DOI: 10.3389/fnins.2024.1353131.Peer-Reviewed Original ResearchPost-traumatic stress disorderTreatment of post-traumatic stress disorderFrontal cortexBrain areasMDMA-assisted psychotherapyEffects of methyloneMonoamine uptake inhibitorsNeuroplasticity-related genesMyelin-related genesAntidepressant-likeAnxiolytic effectsBrain substratesStress disorderPsychiatric disordersNeuropsychiatric disordersUptake inhibitorsBrain effectsAvailable pharmacotherapiesMDMAMDDEmotional learningMethyloneAmygdalaGene expression changesDisorders
2023
Pharmacological effects of methylone and MDMA in humans
Poyatos L, Pérez-Mañá C, Hladun O, Núñez-Montero M, de la Rosa G, Martín S, Barriocanal A, Carabias L, Kelmendi B, Taoussi O, Busardò F, Fonseca F, Torrens M, Pichini S, Farré M, Papaseit E. Pharmacological effects of methylone and MDMA in humans. Frontiers In Pharmacology 2023, 14: 1122861. PMID: 36873994, PMCID: PMC9981643, DOI: 10.3389/fphar.2023.1122861.Peer-Reviewed Original ResearchAddiction Research Center InventoryVisual analog scaleSubjective effectsClinical trialsPharmacological effectsAbuse potentialAcute pharmacological effectsCrossover clinical trialSingle oral doseMechanism of actionBlood pressureEffect profileOral doseAnalog scaleOral administrationHeart ratePrevious historyPsychostimulant usePsychomotor performanceOverall onsetPleasurable effectsMDMAPhysiological effectsShort formEarly disappearance