2023
Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn
Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn A, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie J, Girault J. Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biological Psychiatry 2023, 95: 926-937. PMID: 37579933, PMCID: PMC11059129, DOI: 10.1016/j.biopsych.2023.08.006.Peer-Reviewed Original ResearchStriatal projection neuronsNucleus accumbensPalatable foodProjection neuronsNAc neuronsD2-striatal projection neuronsWild-type miceMessenger RNAConditioning-induced changesSpine densityDopamine neuronsDopamine receptorsDownregulated genesD2 neuronsModulatory roleNAc dopamineDopamine DFood altersCompensatory mechanismsRegular foodNeuronsFeeding behaviorBehavioral responsesMRNA alterationsMice
2011
Beyond the Dopamine Receptor: Regulation and Roles of Serine/Threonine Protein Phosphatases
Walaas SI, Hemmings HC, Greengard P, Nairn AC. Beyond the Dopamine Receptor: Regulation and Roles of Serine/Threonine Protein Phosphatases. Frontiers In Neuroanatomy 2011, 5: 50. PMID: 21904525, PMCID: PMC3162284, DOI: 10.3389/fnana.2011.00050.Peer-Reviewed Original ResearchSerine/threonine proteinARPP-16Signaling pathwaysDARPP-32Striatal signaling pathwaysRegulator of calmodulinMultiple neurological diseasesNovel roleMolecular actionsProteinPP1Monophosphate-regulated phosphoproteinPhosphoproteinMolecular integratorPleiotropic actionsMultiple stepsMajor subclassesDopamine receptorsPathwayHuntington's diseaseRecent studiesStriatal signalingPP2ACentral nervous systemPP2B
2001
ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins.
Dulubova I, Horiuchi A, Snyder G, Girault J, Czernik A, Shao L, Ramabhadran R, Greengard P, Nairn A. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Journal Of Neurochemistry 2001, 77: 229-38. PMID: 11279279, DOI: 10.1046/j.1471-4159.2001.t01-1-00191.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCHO CellsConserved SequenceCorpus StriatumCricetinaeCyclic AMPCyclic AMP-Dependent Protein KinasesHumansIn Vitro TechniquesMaleMiceMultigene FamilyOrgan SpecificityPhosphoproteinsPhosphorylationProtein IsoformsRatsRats, Sprague-DawleyReceptors, Dopamine D1Receptors, Dopamine D2Sequence Homology, Amino AcidConceptsProtein kinase AARPP-19ARPP-16Family of cAMPImportant cellular functionsActivation of PKAIsoform-specific antibodiesYeast genomeD. melanogasterC. elegansProtein familyCellular functionsNon-neuronal cellsSignal transductionConsensus sitesType dopamine receptorsKinase ARelated proteinsPhosphorylated formIntact cellsDopamine receptorsIntracellular messengerBi-directional regulationFamily membersPhosphorylationARPP‐16/ARPP‐19: a highly conserved family of cAMP‐regulated phosphoproteins
Dulubova I, Horiuchi A, Snyder G, Girault J, Czernik A, Shao L, Ramabhadran R, Greengard P, Nairn A. ARPP‐16/ARPP‐19: a highly conserved family of cAMP‐regulated phosphoproteins. Journal Of Neurochemistry 2001, 77: 229-238. DOI: 10.1046/j.1471-4159.2001.00191.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCHO CellsConserved SequenceCorpus StriatumCricetinaeCyclic AMPCyclic AMP-Dependent Protein KinasesHumansIn Vitro TechniquesMaleMiceMultigene FamilyOrgan SpecificityPhosphoproteinsPhosphorylationProtein IsoformsRatsRats, Sprague-DawleyReceptors, Dopamine D1Receptors, Dopamine D2Sequence Homology, Amino AcidConceptsProtein kinase AARPP-19ARPP-16Family of cAMPImportant cellular functionsActivation of PKAIsoform-specific antibodiesYeast genomeD. melanogasterC. elegansProtein familyCellular functionsNon-neuronal cellsSignal transductionConsensus sitesKinase ARelated proteinsΑ-endosulfinePhosphorylated formIntact cellsIntracellular messengerBi-directional regulationDopamine receptorsFamily membersPhosphorylation