Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy
Casella C, Vecchiato K, Cromb D, Guo Y, Winkler A, Hughes E, Dillon L, Green E, Colford K, Egloff A, Siddiqui A, Price A, Grande L, Wood T, Malik S, Teixeira R, Carmichael D, O'Muircheartaigh J. Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy. Epilepsia 2023, 65: 739-752. PMID: 38088235, PMCID: PMC7616339, DOI: 10.1111/epi.17861.Peer-Reviewed Original ResearchDrug-resistant focal epilepsyFocal epilepsyMagnetic resonance imagingTreatment-related side effectsMRI-positive patientsMRI-negative patientsDisease severity measuresWidespread cortical areasPediatric focal epilepsyQuantitative magnetic resonance imagingPeriod of onsetTissue microstructural changesRadiological abnormalitiesUnderlying pathophysiologyHealthy controlsIndividual patientsCortical areasDisease processSide effectsPatientsFocal pathologyEpilepsyNeurobiological alterationsDisease severityResonance imaging