Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism
Dager AD, McKay DR, Kent JW, Curran JE, Knowles E, Sprooten E, Göring H, Dyer TD, Pearlson GD, Olvera RL, Fox PT, Lovallo WR, Duggirala R, Almasy L, Blangero J, Glahn DC. Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism. Neuropsychopharmacology 2014, 40: 412-420. PMID: 25079289, PMCID: PMC4443955, DOI: 10.1038/npp.2014.187.Peer-Reviewed Original ResearchConceptsAmygdala volumeSubcortical volumesFamily historyLifetime AUDAlcohol-related damageGenetic factorsSmaller amygdala volumesPre-existing deficitsAUD riskSuch family historyStructural brain imagesBrain shrinkageDorsal striatumAlcohol abuseNeurotoxic damageVentral striatumSubcortical structuresCommon genetic factorsShared genetic factorsCommon genetic featuresUnrelated controlsMexican-American individualsGenetic featuresStriatumRisk