Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism
Dager AD, McKay DR, Kent JW, Curran JE, Knowles E, Sprooten E, Göring H, Dyer TD, Pearlson GD, Olvera RL, Fox PT, Lovallo WR, Duggirala R, Almasy L, Blangero J, Glahn DC. Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism. Neuropsychopharmacology 2014, 40: 412-420. PMID: 25079289, PMCID: PMC4443955, DOI: 10.1038/npp.2014.187.Peer-Reviewed Original ResearchConceptsAmygdala volumeSubcortical volumesFamily historyLifetime AUDAlcohol-related damageGenetic factorsSmaller amygdala volumesPre-existing deficitsAUD riskSuch family historyStructural brain imagesBrain shrinkageDorsal striatumAlcohol abuseNeurotoxic damageVentral striatumSubcortical structuresCommon genetic factorsShared genetic factorsCommon genetic featuresUnrelated controlsMexican-American individualsGenetic featuresStriatumRiskFunctional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students
Dager AD, Anderson BM, Rosen R, Khadka S, Sawyer B, Jiantonio‐Kelly R, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Pearlson GD. Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students. Addiction 2014, 109: 585-595. PMID: 24304235, PMCID: PMC3951577, DOI: 10.1111/add.12437.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DrinkingAlcohol-Related DisordersAlcoholic BeveragesAlcoholismBinge DrinkingBrainBrain MappingCaudate NucleusCerebral CortexCuesFactor Analysis, StatisticalFemaleFunctional NeuroimagingGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingMalePhotic StimulationPrefrontal CortexRisk FactorsStudentsUniversitiesYoung AdultConceptsHeavy drinkersAlcohol-related problemsBOLD responseFunctional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) responseBlood oxygen level-dependent (BOLD) responseLevel-dependent responsesSingle brain networkSubsequent heavy drinkingPictures of alcoholBaseline factorsRisk factorsModerate drinkersBilateral caudateAnterior cingulateGreater riskOrbitofrontal cortexHeavy drinkingYoung adultsDrinkersDrinking amountGroup differencesBaselineAlcohol cuesLongitudinal studyNeural responses