2024
Assessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers
Silva-Rudberg J, Carrión C, Pérez-Palmer N, Li J, Mehta S, Diab N, Mecca A, O'Dell R. Assessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers. American Journal Of Geriatric Psychiatry 2024, 32: 773-786. PMID: 38336573, PMCID: PMC11162952, DOI: 10.1016/j.jagp.2024.01.030.Peer-Reviewed Original ResearchDiagnosis of mild cognitive impairmentSpanish-speaking patientsMild cognitive impairmentHispanic/Latino patientsCognitive impairmentNon-English language preferenceLanguage preferenceComprehension of diagnosisImpact of language barriersAssessment of disparitiesDiagnosis of cognitive impairmentSpanish language preferenceDiagnosis of dementiaElectronic medical recordsCross-sectional studyTimeliness of diagnosisDementia careRetrospective cross-sectional studyDementia diagnosisHealth disparitiesU.S. Hispanic/Latino populationBinomial logistic regressionNeighborhood disadvantageSpanish speakersHealth care
2018
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging
Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.Peer-Reviewed Original ResearchConceptsPositron emission tomographic imagingSynaptic vesicle glycoprotein 2ASynaptic densityAlzheimer's diseaseEmission tomographic imagingHigh-resolution PET scanningPET scanningCognitive impairmentDisease-modifying therapiesDisease-modifying treatmentsNormal participantsCross-sectional studyPittsburgh compound BMajor structural correlateAmnestic mild cognitive impairmentMagnetic resonance imagingMild cognitive impairmentJ PET imagingRestoration of synapsesSpecific bindingNeurologic evaluationSynaptic lossDisease stagePostmortem studiesOutcome measures