2020
Carbon monoxide: a critical physiological regulator sensitive to light
Oren DA, Sit DK, Goudarzi SH, Wisner KL. Carbon monoxide: a critical physiological regulator sensitive to light. Translational Psychiatry 2020, 10: 87. PMID: 32152296, PMCID: PMC7062897, DOI: 10.1038/s41398-020-0766-1.Peer-Reviewed Original ResearchConceptsHealthy female volunteersAntidepressant effectsPeripheral bloodBlood samplesFemale volunteersConfirmatory studiesPhysiological regulatorPeripheral blood samplesContinuous exposureBright light exposureCritical physiological regulatorHuman evidenceVivo modelNonseasonal depressionBlood carbon monoxideMean carbon monoxideBright white lightAdditional volunteersVolunteersPutative roleCircadian rhythmExposureBloodTherapeutic lightBright light
2015
Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus.
Romerowicz-Misielak M, Oren D, Sowa-Kucma M, Tabecka-Lonczynska A, Gilun P, Stefanczyk-Krzymowska S, Koziorowski M. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. Journal Of Physiology And Pharmacology 2015, 66: 505-14. PMID: 26348075.Peer-Reviewed Original ResearchConceptsOphthalmic venous bloodVenous bloodNocturnal melatonin riseMelatonin levelsMelatonin riseWinter seasonal affective disorderNocturnal melatonin peakSeasonal affective disorderHour infusionCavernous sinusVenous sinusesNon-physiological changesAutologous blood plasmaAffective disordersSynthesis of melatoninBright light effectsBloodAANAT protein levelsMelatonin peakProtein levelsAcute impactSinusTreatmentBlood plasmaParallel changes
2013
SAD and the Not-So-Single Photoreceptors
Oren DA, Koziorowski M, Desan PH. SAD and the Not-So-Single Photoreceptors. American Journal Of Psychiatry 2013, 170: 1403-1412. PMID: 23929223, DOI: 10.1176/appi.ajp.2013.13010111.Peer-Reviewed Original ResearchConceptsMolecular mechanismsSeasonal affective disorderCircannual regulationCritical regulatorTetrapyrrole pigmentsDevelopment of therapiesRole of rodsInfluence of lightPhotoreceptorsCone photoreceptorsLight treatmentAntidepressant effectsPhysiologyAnimal modelsAffective disordersRecent studiesSingle photoreceptorsPhototransductionRegulatorDisordersRegulationMechanismGasotransmitterRolePigments
2005
Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment
Postolache T, Oren D. Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment. Clinics In Sports Medicine 2005, 24: 381-413. PMID: 15892931, DOI: 10.1016/j.csm.2004.12.005.Peer-Reviewed Original Research
2001
Stimulation of reactive oxygen species production by an antidepressant visible light source
Oren D, Charney D, Lavie R, Sinyakov M, Lubart R. Stimulation of reactive oxygen species production by an antidepressant visible light source. Biological Psychiatry 2001, 49: 464-467. PMID: 11274659, DOI: 10.1016/s0006-3223(00)01106-9.Peer-Reviewed Original Research
1998
Tweaking the human circadian clock with light.
Oren D, Terman M. Tweaking the human circadian clock with light. Science 1998, 279: 333-4. PMID: 9454328, DOI: 10.1126/science.279.5349.333.Peer-Reviewed Original Research
1997
Bilirubin, Rem Sleep, and Phototransduction of Environmental Time Cues. A Hypothesis
Oren D. Bilirubin, Rem Sleep, and Phototransduction of Environmental Time Cues. A Hypothesis. Chronobiology International 1997, 14: 319-329. PMID: 9167892, DOI: 10.3109/07420529709001423.Peer-Reviewed Original ResearchConceptsBiological clockEndogenous biological clockPlant phytochromesEvolutionary roleBiological clock systemEnvironmental time cuesDifferent speciesZeitgeber signalsClock systemVisual pigmentsHeme moietyCommon molecular structurePrimary effectPhototransductionBiological rhythmsPlantsPrevailing hypothesisPigmentsSimilar chromophoresTime cuesClockAnimalsPhytochromeSpeciesBile pigments
1995
Effects of season on electro-oculographic ratio in winter seasonal affective disorder
Ozaki N, Rosenthal N, Myers F, Schwartz P, Oren D. Effects of season on electro-oculographic ratio in winter seasonal affective disorder. Psychiatry Research 1995, 59: 151-155. PMID: 8771230, DOI: 10.1016/0165-1781(95)02788-2.Peer-Reviewed Original ResearchThe phototherapy light visor: more to it than meets the eye
Teicher M, Glod C, Oren D, Schwartz P, Luetke C, Brown C, Rosenthal N. The phototherapy light visor: more to it than meets the eye. American Journal Of Psychiatry 1995, 152: 1197-1202. PMID: 7625470, DOI: 10.1176/ajp.152.8.1197.Peer-Reviewed Original ResearchConceptsAtypical depressive symptomsLight visorDepressive symptomsHamilton Depression Scale scoresHamilton Depression Rating ScaleBaseline depression scoresDepression Rating ScaleDepression Scale scoresFull clinical responseModerate response rateSeasonal affective disorderDim red lightClinical responseTherapeutic responseTreatment periodEffective treatmentDepression scoresPatientsResponse rateScale scoreAffective disordersRating ScaleBright white lightSignificant differencesSymptoms
1994
Exposure to ambient light in patients with winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Brown C, Yamada E, Rosenthal N. Exposure to ambient light in patients with winter seasonal affective disorder. American Journal Of Psychiatry 1994, 151: 591-593. PMID: 8147459, DOI: 10.1176/ajp.151.4.591.Peer-Reviewed Original ResearchConceptsWinter seasonal affective disorderSeasonal affective disorderAffective disordersSeverity of depressionNormal comparison subjectsMorning light exposureNormal subjectsComparison subjectsGreater severityPatientsDepressionDisordersExposure profilesSeverityExposureLight exposureSubjectsShort photoperiodOutpatientsLight monitorWeeks
1993
Side effects of light therapy in seasonal affective disorder
Levitt A, Joffe R, Moul D, Lam R, Teicher M, Lebegue B, Murray M, Oren D, Schwartz P, Buchanan A. Side effects of light therapy in seasonal affective disorder. American Journal Of Psychiatry 1993, 150: 650-652. PMID: 8465886, DOI: 10.1176/ajp.150.4.650.Peer-Reviewed Original Research
1991
Treatment of seasonal affective disorder with green light and red light
Oren D, Brainard G, Johnston S, Joseph-Vanderpool J, Sorek E, Rosenthal N. Treatment of seasonal affective disorder with green light and red light. American Journal Of Psychiatry 1991, 148: 509-511. PMID: 2006698, DOI: 10.1176/ajp.148.4.509.Peer-Reviewed Original ResearchAdaptation to dim light in depressed patients with seasonal affective disorder
Oren D, Joseph-Vanderpool J, Rosenthal N. Adaptation to dim light in depressed patients with seasonal affective disorder. Psychiatry Research 1991, 36: 187-193. PMID: 2017533, DOI: 10.1016/0165-1781(91)90130-h.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderAffective disordersDrug-free healthy controlsSAD patientsManic-depressive illnessWinter seasonal affective disorderPossible trait markerDepressed SAD patientsDepressive episodeDepressed patientsHealthy controlsDark adaptation curvePatientsTrait markerDiminished sensitivityDisordersSupersensitivity