2020
Carbon monoxide: a critical physiological regulator sensitive to light
Oren DA, Sit DK, Goudarzi SH, Wisner KL. Carbon monoxide: a critical physiological regulator sensitive to light. Translational Psychiatry 2020, 10: 87. PMID: 32152296, PMCID: PMC7062897, DOI: 10.1038/s41398-020-0766-1.Peer-Reviewed Original ResearchConceptsHealthy female volunteersAntidepressant effectsPeripheral bloodBlood samplesFemale volunteersConfirmatory studiesPhysiological regulatorPeripheral blood samplesContinuous exposureBright light exposureCritical physiological regulatorHuman evidenceVivo modelNonseasonal depressionBlood carbon monoxideMean carbon monoxideBright white lightAdditional volunteersVolunteersPutative roleCircadian rhythmExposureBloodTherapeutic lightBright light
2015
Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus.
Romerowicz-Misielak M, Oren D, Sowa-Kucma M, Tabecka-Lonczynska A, Gilun P, Stefanczyk-Krzymowska S, Koziorowski M. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. Journal Of Physiology And Pharmacology 2015, 66: 505-14. PMID: 26348075.Peer-Reviewed Original ResearchConceptsOphthalmic venous bloodVenous bloodNocturnal melatonin riseMelatonin levelsMelatonin riseWinter seasonal affective disorderNocturnal melatonin peakSeasonal affective disorderHour infusionCavernous sinusVenous sinusesNon-physiological changesAutologous blood plasmaAffective disordersSynthesis of melatoninBright light effectsBloodAANAT protein levelsMelatonin peakProtein levelsAcute impactSinusTreatmentBlood plasmaParallel changes
2005
Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment
Postolache T, Oren D. Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment. Clinics In Sports Medicine 2005, 24: 381-413. PMID: 15892931, DOI: 10.1016/j.csm.2004.12.005.Peer-Reviewed Original Research
2004
Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings.
Epperson CN, Terman M, Terman JS, Hanusa BH, Oren DA, Peindl KS, Wisner KL. Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. The Journal Of Clinical Psychiatry 2004, 65: 421-5. PMID: 15096083, DOI: 10.4088/jcp.v65n0319.Peer-Reviewed Original ResearchConceptsBright light therapyClinical trialsLight therapyAntepartum depressionDouble-blind placebo-controlled pilot studyPlacebo-controlled pilot studyRecent open-label studyDSM-IV major depressive disorderOpen-label studyAntidepressant drug trialsRandomized clinical trialsMajor depressive disorderAntidepressants resultsStructured interview guideActive treatmentClinical statusPregnant womenSuccessful treatmentDepressive disorderPlacebo lightDrug trialsPromising treatmentSalivary melatoninExtension phasePilot study
2002
An Open Trial of Morning Light Therapy for Treatment of Antepartum Depression
Oren D, Wisner K, Spinelli M, Epperson C, Peindl K, Terman J, Terman M. An Open Trial of Morning Light Therapy for Treatment of Antepartum Depression. American Journal Of Psychiatry 2002, 159: 666-669. PMID: 11925310, DOI: 10.1176/appi.ajp.159.4.666.Peer-Reviewed Original ResearchConceptsWeeks of treatmentMorning light therapyBright light therapyLight therapyAntepartum depressionOpen trialMajor depressionMorning bright light therapyHamilton Depression Rating ScaleSeasonal Affective Disorder VersionDepression Rating ScaleNovel treatment approachesFollow-up questionnairePregnant patientsAntidepressant effectsPregnant womenDepression ratingsTreatment approachesTherapyRating ScaleAdverse effectsDepressionTrialsWeeksPregnancy
2001
Stimulation of reactive oxygen species production by an antidepressant visible light source
Oren D, Charney D, Lavie R, Sinyakov M, Lubart R. Stimulation of reactive oxygen species production by an antidepressant visible light source. Biological Psychiatry 2001, 49: 464-467. PMID: 11274659, DOI: 10.1016/s0006-3223(00)01106-9.Peer-Reviewed Original Research
2000
Genetic polymorphism at the CLOCK gene locus and major depression
Desan P, Oren D, Malison R, Price L, Rosenbaum J, Smoller J, Charney D, Gelernter J. Genetic polymorphism at the CLOCK gene locus and major depression. American Journal Of Medical Genetics 2000, 96: 418-421. PMID: 10898925, DOI: 10.1002/1096-8628(20000612)96:3<418::aid-ajmg34>3.0.co;2-s.Peer-Reviewed Original Research
1998
Heisenberg meets photobiology?
Oren D. Heisenberg meets photobiology? Science 1998, 279: 969. PMID: 9490481, DOI: 10.1126/science.279.5353.963h.Peer-Reviewed Original ResearchTweaking the human circadian clock with light.
Oren D, Terman M. Tweaking the human circadian clock with light. Science 1998, 279: 333-4. PMID: 9454328, DOI: 10.1126/science.279.5349.333.Peer-Reviewed Original Research
1997
Effects of Meta-chlorophenylpiperazine Infusions in Patients With Seasonal Affective Disorder and Healthy Control Subjects: Diurnal Responses and Nocturnal Regulatory Mechanisms
Schwartz P, Murphy D, Wehr T, Garcia-Borreguero D, Oren D, Moul D, Ozaki N, Snelbaker A, Rosenthal N. Effects of Meta-chlorophenylpiperazine Infusions in Patients With Seasonal Affective Disorder and Healthy Control Subjects: Diurnal Responses and Nocturnal Regulatory Mechanisms. JAMA Psychiatry 1997, 54: 375-385. PMID: 9107154, DOI: 10.1001/archpsyc.1997.01830160103013.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderHealthy control subjectsGrowth hormone concentrationsControl subjectsNocturnal core temperatureDepressed patientsHormone concentrationsNervous systemAffective disordersCore temperatureMean growth hormone concentrationWinter depressionSympathetic nervous systemBrain serotonergic systemCentral nervous systemSignificant reductionBright light treatmentUniform abnormalityNorepinephrine responseNorepinephrine concentrationsSerotonin transmissionSelf-Rating ScaleAdrenal axisSerotonergic agentsDepression ratingsRestoration of detectable melatonin after entrainment to a 24-hour schedule in a ‘free-running’ man
Oren D, Giesen H, Wehr T. Restoration of detectable melatonin after entrainment to a 24-hour schedule in a ‘free-running’ man. Psychoneuroendocrinology 1997, 22: 39-52. PMID: 9141150, DOI: 10.1016/s0306-4530(96)00038-8.Peer-Reviewed Original ResearchConceptsGRF-44Multiple endocrine abnormalitiesInfusion of TRHPineal gland secretionNocturnal melatonin secretionAbnormal endocrine functionCircadian rhythm disordersSleep-wake disordersGH responseThyrotropin levelsEndocrine abnormalitiesCRH infusionEndocrine challengesDifferential diagnosisAbnormal responseGonadal axesEndocrine functionRhythm disordersSerum melatoninGrowth hormoneMelatonin secretionDaily exposureCircadian profileMelatoninLux light
1996
Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder
Oren D, Levendosky A, Kasper S, Duncan C, Rosenthal N. Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder. Biological Psychiatry 1996, 39: 157-170. PMID: 8837977, DOI: 10.1016/0006-3223(95)00079-8.Peer-Reviewed Original Research
1995
Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome.
Oren D, Turner E, Wehr T. Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome. Journal Of Neurology Neurosurgery & Psychiatry 1995, 58: 379. PMID: 7897427, PMCID: PMC1073383, DOI: 10.1136/jnnp.58.3.379.Peer-Reviewed Original Research
1994
Exposure to ambient light in patients with winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Brown C, Yamada E, Rosenthal N. Exposure to ambient light in patients with winter seasonal affective disorder. American Journal Of Psychiatry 1994, 151: 591-593. PMID: 8147459, DOI: 10.1176/ajp.151.4.591.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareCircadian RhythmFemaleHumansLightMalePhotoperiodSeasonal Affective DisorderSeasonsSeverity of Illness IndexConceptsWinter seasonal affective disorderSeasonal affective disorderAffective disordersSeverity of depressionNormal comparison subjectsMorning light exposureNormal subjectsComparison subjectsGreater severityPatientsDepressionDisordersExposure profilesSeverityExposureLight exposureSubjectsShort photoperiodOutpatientsLight monitorWeeks
1992
Hypernyctohemeral Syndrome after Chronotherapy for Delayed Sleep Phase Syndrome
Oren D, Wehr T. Hypernyctohemeral Syndrome after Chronotherapy for Delayed Sleep Phase Syndrome. New England Journal Of Medicine 1992, 327: 1762. PMID: 1435929, DOI: 10.1056/nejm199212103272417.Peer-Reviewed Original Research
1991
Usage patterns of phototherapy in seasonal affective disorder
Oren D, Shannon N, Carpenter C, Rosenthal N. Usage patterns of phototherapy in seasonal affective disorder. Comprehensive Psychiatry 1991, 32: 147-152. PMID: 2022114, DOI: 10.1016/0010-440x(91)90007-y.Peer-Reviewed Original ResearchRetinal melatonin and dopamine in seasonal affective disorder
Oren D. Retinal melatonin and dopamine in seasonal affective disorder. Journal Of Neural Transmission 1991, 83: 85-95. PMID: 2018631, DOI: 10.1007/bf01244455.Peer-Reviewed Original Research