2013
SAD and the Not-So-Single Photoreceptors
Oren DA, Koziorowski M, Desan PH. SAD and the Not-So-Single Photoreceptors. American Journal Of Psychiatry 2013, 170: 1403-1412. PMID: 23929223, DOI: 10.1176/appi.ajp.2013.13010111.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansLightLight Signal TransductionNeuronsPhotoreceptor Cells, VertebrateRod OpsinsSeasonal Affective DisorderSignal TransductionConceptsMolecular mechanismsSeasonal affective disorderCircannual regulationCritical regulatorTetrapyrrole pigmentsDevelopment of therapiesRole of rodsInfluence of lightPhotoreceptorsCone photoreceptorsLight treatmentAntidepressant effectsPhysiologyAnimal modelsAffective disordersRecent studiesSingle photoreceptorsPhototransductionRegulatorDisordersRegulationMechanismGasotransmitterRolePigments
2005
Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment
Postolache T, Oren D. Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment. Clinics In Sports Medicine 2005, 24: 381-413. PMID: 15892931, DOI: 10.1016/j.csm.2004.12.005.Peer-Reviewed Original Research
2002
An Open Trial of Morning Light Therapy for Treatment of Antepartum Depression
Oren D, Wisner K, Spinelli M, Epperson C, Peindl K, Terman J, Terman M. An Open Trial of Morning Light Therapy for Treatment of Antepartum Depression. American Journal Of Psychiatry 2002, 159: 666-669. PMID: 11925310, DOI: 10.1176/appi.ajp.159.4.666.Peer-Reviewed Original ResearchConceptsWeeks of treatmentMorning light therapyBright light therapyLight therapyAntepartum depressionOpen trialMajor depressionMorning bright light therapyHamilton Depression Rating ScaleSeasonal Affective Disorder VersionDepression Rating ScaleNovel treatment approachesFollow-up questionnairePregnant patientsAntidepressant effectsPregnant womenDepression ratingsTreatment approachesTherapyRating ScaleAdverse effectsDepressionTrialsWeeksPregnancy
2001
Bright Light Therapy for Schizoaffective Disorder
OREN D, CUBELLS J, LITSCH S. Bright Light Therapy for Schizoaffective Disorder. American Journal Of Psychiatry 2001, 158: 2086-a-2087. PMID: 11729035, DOI: 10.1176/appi.ajp.158.12.2086-a.Peer-Reviewed Original ResearchComorbidityHumansMaleMiddle AgedPhototherapyPsychotic DisordersSeasonal Affective DisorderTreatment OutcomeStimulation of reactive oxygen species production by an antidepressant visible light source
Oren D, Charney D, Lavie R, Sinyakov M, Lubart R. Stimulation of reactive oxygen species production by an antidepressant visible light source. Biological Psychiatry 2001, 49: 464-467. PMID: 11274659, DOI: 10.1016/s0006-3223(00)01106-9.Peer-Reviewed Original ResearchCell LineCircadian RhythmDepressionFibroblastsLightReactive Oxygen SpeciesSeasonal Affective DisorderSignal TransductionTime Factors
2000
No effect of light on basal glucagon levels in winter seasonal depressives and comparison subjects
Oren D, Berman R, Anand A, Charney D. No effect of light on basal glucagon levels in winter seasonal depressives and comparison subjects. Psychiatry Research 2000, 94: 263-266. PMID: 10889291, DOI: 10.1016/s0165-1781(00)00158-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive Disorder, MajorFemaleGlucagonHumansMalePhototherapySeasonal Affective DisorderSeasonsTreatment Outcome
1999
There Is Nothing New Under the Sun
OREN D. There Is Nothing New Under the Sun. American Journal Of Psychiatry 1999, 156: 336-336. PMID: 9989577, DOI: 10.1176/ajp.156.2.336.Peer-Reviewed Original Research
1998
Tweaking the human circadian clock with light.
Oren D, Terman M. Tweaking the human circadian clock with light. Science 1998, 279: 333-4. PMID: 9454328, DOI: 10.1126/science.279.5349.333.Peer-Reviewed Original Research
1997
Effects of Meta-chlorophenylpiperazine Infusions in Patients With Seasonal Affective Disorder and Healthy Control Subjects: Diurnal Responses and Nocturnal Regulatory Mechanisms
Schwartz P, Murphy D, Wehr T, Garcia-Borreguero D, Oren D, Moul D, Ozaki N, Snelbaker A, Rosenthal N. Effects of Meta-chlorophenylpiperazine Infusions in Patients With Seasonal Affective Disorder and Healthy Control Subjects: Diurnal Responses and Nocturnal Regulatory Mechanisms. JAMA Psychiatry 1997, 54: 375-385. PMID: 9107154, DOI: 10.1001/archpsyc.1997.01830160103013.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderHealthy control subjectsGrowth hormone concentrationsControl subjectsNocturnal core temperatureDepressed patientsHormone concentrationsNervous systemAffective disordersCore temperatureMean growth hormone concentrationWinter depressionSympathetic nervous systemBrain serotonergic systemCentral nervous systemSignificant reductionBright light treatmentUniform abnormalityNorepinephrine responseNorepinephrine concentrationsSerotonin transmissionSelf-Rating ScaleAdrenal axisSerotonergic agentsDepression ratings
1996
Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder
Oren D, Levendosky A, Kasper S, Duncan C, Rosenthal N. Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder. Biological Psychiatry 1996, 39: 157-170. PMID: 8837977, DOI: 10.1016/0006-3223(95)00079-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultCircadian RhythmFemaleHumansHydrocortisoneMaleMiddle AgedPersonality InventoryPhototherapyProlactinReference ValuesSeasonal Affective DisorderThyrotropin
1995
Effects of season on electro-oculographic ratio in winter seasonal affective disorder
Ozaki N, Rosenthal N, Myers F, Schwartz P, Oren D. Effects of season on electro-oculographic ratio in winter seasonal affective disorder. Psychiatry Research 1995, 59: 151-155. PMID: 8771230, DOI: 10.1016/0165-1781(95)02788-2.Peer-Reviewed Original ResearchThe phototherapy light visor: more to it than meets the eye
Teicher M, Glod C, Oren D, Schwartz P, Luetke C, Brown C, Rosenthal N. The phototherapy light visor: more to it than meets the eye. American Journal Of Psychiatry 1995, 152: 1197-1202. PMID: 7625470, DOI: 10.1176/ajp.152.8.1197.Peer-Reviewed Original ResearchMeSH KeywordsAdultColorFemaleHumansLightMalePhototherapyPlacebosSeasonal Affective DisorderTreatment OutcomeConceptsAtypical depressive symptomsLight visorDepressive symptomsHamilton Depression Scale scoresHamilton Depression Rating ScaleBaseline depression scoresDepression Rating ScaleDepression Scale scoresFull clinical responseModerate response rateSeasonal affective disorderDim red lightClinical responseTherapeutic responseTreatment periodEffective treatmentDepression scoresPatientsResponse rateScale scoreAffective disordersRating ScaleBright white lightSignificant differencesSymptoms
1994
1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light
Oren D, Schulkin J, Rosenthal N. 1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light. Psychopharmacology 1994, 116: 515-516. PMID: 7701056, DOI: 10.1007/bf02247486.Peer-Reviewed Original ResearchA controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder
Oren D, Teicher M, Schwartz P, Glod C, Turner E, Ito Y, Sedway J, Rosenthal N, Wehr T. A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder. Journal Of Affective Disorders 1994, 32: 197-200. PMID: 7852661, DOI: 10.1016/0165-0327(94)90018-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedPlacebosPsychiatric Status Rating ScalesSeasonal Affective DisorderTreatment OutcomeVitamin B 12ConceptsSeasonal affective disorderWinter seasonal affective disorderAffective disordersEffective short-term treatmentWeekly outpatient visitsShort-term treatmentSIGH-SAD scoresPlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodEffective treatmentSame scheduleVitamin B12SAD patientsSignificant differencesTreatmentPatientsWeeksDisordersCyanocobalaminRandom assignmentPlaceboTrialsVisitsPlatelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder
Ozaki N, Rosenthal N, Mazzola P, Chiueh C, Hardin T, Garcia-Borreguero D, Schwartz P, Turner E, Oren D, Murphy D. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological Psychiatry 1994, 36: 458-466. PMID: 7811842, DOI: 10.1016/0006-3223(94)90641-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinding SitesBlood PlateletsCalciumFemaleHumansMaleMiddle AgedParoxetinePsychiatric Status Rating ScalesSeasonal Affective DisorderSerotoninConceptsSeasonal affective disorderWinter seasonal affective disorderSAD patientsAffective disordersBrain serotonergic systemSerotonergic measuresSerotonergic abnormalitiesSerotonergic functionDensity-dependent subpopulationsPlatelet turnoverSerotonergic systemPatientsReceptor functionNeurotransmitter aminesTherapy conditionsHigher BmaxLight plateletsPlateletsDisordersPresent studyHeavy plateletsCa2SerotoninA Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder
OREN D, MOUL D, SCHWARTZ P, WEHR T, ROSENTHAL N. A Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder. Journal Of Clinical Psychopharmacology 1994, 14: 196-200. PMID: 8027416, DOI: 10.1097/00004714-199406000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarbidopaDopamineDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansLevodopaMalePsychological TestsSeasonal Affective DisorderConceptsSeasonal affective disorderWinter seasonal affective disorderDopaminergic deficiencyAffective disordersItem Hamilton Rating ScaleEfficacy of levodopaUse of levodopaWeekly outpatient visitsHamilton Rating ScalePlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodRate of responseDepression scoresPatientsLevodopaPlaceboCarbidopaRating ScaleIdentical scheduleSAD patientsTreatmentWeeksDisordersExposure to ambient light in patients with winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Brown C, Yamada E, Rosenthal N. Exposure to ambient light in patients with winter seasonal affective disorder. American Journal Of Psychiatry 1994, 151: 591-593. PMID: 8147459, DOI: 10.1176/ajp.151.4.591.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareCircadian RhythmFemaleHumansLightMalePhotoperiodSeasonal Affective DisorderSeasonsSeverity of Illness IndexConceptsWinter seasonal affective disorderSeasonal affective disorderAffective disordersSeverity of depressionNormal comparison subjectsMorning light exposureNormal subjectsComparison subjectsGreater severityPatientsDepressionDisordersExposure profilesSeverityExposureLight exposureSubjectsShort photoperiodOutpatientsLight monitorWeeksEFFECTS OF LIGHT ON T‐CELLS IN HIV‐INFECTED SUBJECTS ARE NOT DEPENDENT ON HISTORY OF SEASONAL AFFECTIVE DISORDER
Rosenthal N, Brown C, Oren D, Galetto G, Schwartz P, Malley J. EFFECTS OF LIGHT ON T‐CELLS IN HIV‐INFECTED SUBJECTS ARE NOT DEPENDENT ON HISTORY OF SEASONAL AFFECTIVE DISORDER. Photochemistry And Photobiology 1994, 59: 314-319. PMID: 7912442, DOI: 10.1111/j.1751-1097.1994.tb05040.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD4-Positive T-LymphocytesFemaleHIV InfectionsHumansLeukocyte CountMaleMiddle AgedPhototherapySeasonal Affective DisorderT-LymphocytesConceptsSeasonal affective disorderSuppressor T-cell countsSignificant mood improvementPotential therapeutic valuePlasma cortisol levelsCD8 levelsHigher CD4Treatment modalitiesT cellsLight therapyCortisol levelsCrossover designAffective disordersCell countHIVTherapeutic valueMood improvementBright light conditionsSignificant differencesTreatment conditionsHigher cell countsDisordersSubjectsVisible red lightCountHigh titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness
Natelson B, Ye N, Moul D, Jenkins F, Oren D, Tapp W, Cheng Y. High titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness. Journal Of Medical Virology 1994, 42: 42-46. PMID: 8308519, DOI: 10.1002/jmv.1890420109.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeEpstein-Barr virusEBV DNA polymeraseSeasonal affective disorderAbnormal testsFatiguing illnessesSAD patientsSubset of patientsAbnormal titersCFS patientsSymptomatic patientsFatigue syndromePatient groupTreatment trialsHealthy controlsPatientsNormal rangeAffective disordersDisease severityUseful markerHigh titersAge rangeSocioeconomic classAntibodiesIllness
1993
Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder
Ozaki N, Rosenthal N, Moul D, Schwartz P, Oren D. Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder. Psychiatry Research 1993, 49: 99-107. PMID: 8153191, DOI: 10.1016/0165-1781(93)90098-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedElectrooculographyFemaleHumansMaleMiddle AgedPhototherapySeasonal Affective DisorderSingle-Blind MethodConceptsSeasonal affective disorderControl subjectsLight therapyEOG ratiosSAD patientsAffective disordersEffect of phototherapyNormal control subjectsWinter seasonal affective disorderRetinal abnormalitiesPatientsConfounding factorsEOG testingTherapyDisordersSubjectsTest variabilityOutpatientsAbnormalitiesPhototherapy